| Full name: myosin heavy chain 8 | Alias Symbol: MyHC-peri|MyHC-pn | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 4626 | HGNC ID: HGNC:7578 | Ensembl Gene: ENSG00000133020 | OMIM ID: 160741 |
| Drug and gene relationship at DGIdb | |||
MYH8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of MYH8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYH8 | 4626 | 34471_at | 0.0313 | 0.9177 | |
| GSE20347 | MYH8 | 4626 | 206717_at | -0.0059 | 0.9160 | |
| GSE23400 | MYH8 | 4626 | 34471_at | -0.0400 | 0.1093 | |
| GSE26886 | MYH8 | 4626 | 206717_at | -0.0914 | 0.3596 | |
| GSE29001 | MYH8 | 4626 | 34471_at | -0.0704 | 0.5885 | |
| GSE38129 | MYH8 | 4626 | 206717_at | -0.0164 | 0.7309 | |
| GSE45670 | MYH8 | 4626 | 206717_at | 0.0604 | 0.4082 | |
| GSE53622 | MYH8 | 4626 | 2247 | 0.1589 | 0.1784 | |
| GSE53624 | MYH8 | 4626 | 2247 | 0.8899 | 0.0000 | |
| GSE63941 | MYH8 | 4626 | 206717_at | 0.1457 | 0.2330 | |
| GSE77861 | MYH8 | 4626 | 206717_at | -0.0557 | 0.7641 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MYH8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYH8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYH8 | 4626 | 2 | 4 | 24 | |
| GSE20123 | MYH8 | 4626 | 2 | 5 | 23 | |
| GSE43470 | MYH8 | 4626 | 2 | 5 | 36 | |
| GSE46452 | MYH8 | 4626 | 34 | 1 | 24 | |
| GSE47630 | MYH8 | 4626 | 7 | 1 | 32 | |
| GSE54993 | MYH8 | 4626 | 4 | 3 | 63 | |
| GSE54994 | MYH8 | 4626 | 5 | 8 | 40 | |
| GSE60625 | MYH8 | 4626 | 4 | 0 | 7 | |
| GSE74703 | MYH8 | 4626 | 2 | 3 | 31 | |
| GSE74704 | MYH8 | 4626 | 1 | 2 | 17 | |
| TCGA | MYH8 | 4626 | 17 | 20 | 59 |
Total number of gains: 80; Total number of losses: 52; Total Number of normals: 356.
Somatic mutations of MYH8:
Generating mutation plots.
Highly correlated genes for MYH8:
Showing top 20/276 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYH8 | OR2J2 | 0.762055 | 3 | 0 | 3 |
| MYH8 | KIR2DS2 | 0.759248 | 3 | 0 | 3 |
| MYH8 | IFNA7 | 0.75801 | 3 | 0 | 3 |
| MYH8 | NEURL1 | 0.73932 | 3 | 0 | 3 |
| MYH8 | LGALS14 | 0.739055 | 3 | 0 | 3 |
| MYH8 | CEACAM21 | 0.72721 | 4 | 0 | 3 |
| MYH8 | FSTL4 | 0.712924 | 3 | 0 | 3 |
| MYH8 | GRM2 | 0.704138 | 3 | 0 | 3 |
| MYH8 | ASCL3 | 0.703886 | 3 | 0 | 3 |
| MYH8 | CLCNKB | 0.697354 | 3 | 0 | 3 |
| MYH8 | RNF185-AS1 | 0.695959 | 3 | 0 | 3 |
| MYH8 | SERPINA6 | 0.693151 | 3 | 0 | 3 |
| MYH8 | PLCB2 | 0.686877 | 3 | 0 | 3 |
| MYH8 | COL4A3 | 0.67777 | 3 | 0 | 3 |
| MYH8 | CYP11B1 | 0.677331 | 4 | 0 | 3 |
| MYH8 | CTRC | 0.672876 | 3 | 0 | 3 |
| MYH8 | CDH10 | 0.670718 | 4 | 0 | 4 |
| MYH8 | GNRHR | 0.670249 | 3 | 0 | 3 |
| MYH8 | PAPPA2 | 0.668188 | 3 | 0 | 3 |
| MYH8 | PNOC | 0.667437 | 3 | 0 | 3 |
For details and further investigation, click here
