| Full name: protein phosphatase, Mg2+/Mn2+ dependent 1E | Alias Symbol: POPX1|KIAA1072|PP2CH|CaMKP-N | ||
| Type: protein-coding gene | Cytoband: 17q24.2 | ||
| Entrez ID: 22843 | HGNC ID: HGNC:19322 | Ensembl Gene: ENSG00000175175 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of PPM1E:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPM1E | 22843 | 205938_at | -0.0501 | 0.8445 | |
| GSE20347 | PPM1E | 22843 | 205938_at | 0.1241 | 0.0178 | |
| GSE23400 | PPM1E | 22843 | 205938_at | -0.0726 | 0.1003 | |
| GSE26886 | PPM1E | 22843 | 205938_at | -0.1546 | 0.1695 | |
| GSE29001 | PPM1E | 22843 | 205938_at | 0.1159 | 0.6344 | |
| GSE38129 | PPM1E | 22843 | 205938_at | 0.0802 | 0.2369 | |
| GSE45670 | PPM1E | 22843 | 205938_at | 0.0787 | 0.6156 | |
| GSE53622 | PPM1E | 22843 | 107871 | -0.3502 | 0.0935 | |
| GSE53624 | PPM1E | 22843 | 107871 | 0.1334 | 0.5226 | |
| GSE63941 | PPM1E | 22843 | 236302_at | 0.3074 | 0.8525 | |
| GSE77861 | PPM1E | 22843 | 205938_at | -0.1106 | 0.3070 | |
| SRP064894 | PPM1E | 22843 | RNAseq | 0.8130 | 0.0055 | |
| SRP133303 | PPM1E | 22843 | RNAseq | 0.2344 | 0.6042 | |
| SRP159526 | PPM1E | 22843 | RNAseq | 0.9774 | 0.1327 | |
| TCGA | PPM1E | 22843 | RNAseq | -0.6699 | 0.0538 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPM1E expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPM1E:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPM1E | 22843 | 6 | 1 | 23 | |
| GSE20123 | PPM1E | 22843 | 6 | 1 | 23 | |
| GSE43470 | PPM1E | 22843 | 3 | 0 | 40 | |
| GSE46452 | PPM1E | 22843 | 32 | 0 | 27 | |
| GSE47630 | PPM1E | 22843 | 7 | 1 | 32 | |
| GSE54993 | PPM1E | 22843 | 2 | 5 | 63 | |
| GSE54994 | PPM1E | 22843 | 8 | 6 | 39 | |
| GSE60625 | PPM1E | 22843 | 4 | 0 | 7 | |
| GSE74703 | PPM1E | 22843 | 3 | 0 | 33 | |
| GSE74704 | PPM1E | 22843 | 5 | 1 | 14 | |
| TCGA | PPM1E | 22843 | 26 | 7 | 63 |
Total number of gains: 102; Total number of losses: 22; Total Number of normals: 364.
Somatic mutations of PPM1E:
Generating mutation plots.
Highly correlated genes for PPM1E:
Showing top 20/390 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPM1E | SPTA1 | 0.714534 | 3 | 0 | 3 |
| PPM1E | RAB39B | 0.71078 | 3 | 0 | 3 |
| PPM1E | TCP10L | 0.707078 | 3 | 0 | 3 |
| PPM1E | OR2J2 | 0.683856 | 3 | 0 | 3 |
| PPM1E | MSI1 | 0.682385 | 3 | 0 | 3 |
| PPM1E | SLC17A6 | 0.678017 | 3 | 0 | 3 |
| PPM1E | CCDC7 | 0.677173 | 3 | 0 | 3 |
| PPM1E | MSH4 | 0.667786 | 5 | 0 | 5 |
| PPM1E | NPTXR | 0.665849 | 3 | 0 | 3 |
| PPM1E | TULP2 | 0.66583 | 3 | 0 | 3 |
| PPM1E | ZIC4 | 0.665675 | 3 | 0 | 3 |
| PPM1E | TAS2R7 | 0.658279 | 3 | 0 | 3 |
| PPM1E | MKRN3 | 0.65627 | 3 | 0 | 3 |
| PPM1E | TMPRSS15 | 0.656188 | 3 | 0 | 3 |
| PPM1E | SRRM4 | 0.6555 | 3 | 0 | 3 |
| PPM1E | UBQLN3 | 0.654673 | 3 | 0 | 3 |
| PPM1E | CYLC2 | 0.653942 | 3 | 0 | 3 |
| PPM1E | GRM7 | 0.648912 | 5 | 0 | 4 |
| PPM1E | MUC19 | 0.648225 | 3 | 0 | 3 |
| PPM1E | PCBP3 | 0.648116 | 3 | 0 | 3 |
For details and further investigation, click here
