| Full name: adrenoceptor alpha 1D | Alias Symbol: ADRA1R|ADRA1A|ADRA1 | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 146 | HGNC ID: HGNC:280 | Ensembl Gene: ENSG00000171873 | OMIM ID: 104219 |
| Drug and gene relationship at DGIdb | |||
ADRA1D involved pathways:
Expression of ADRA1D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADRA1D | 146 | 210960_at | 0.1125 | 0.6084 | |
| GSE20347 | ADRA1D | 146 | 210960_at | -0.1860 | 0.0020 | |
| GSE23400 | ADRA1D | 146 | 210960_at | -0.1362 | 0.0000 | |
| GSE26886 | ADRA1D | 146 | 210960_at | 0.0059 | 0.9604 | |
| GSE29001 | ADRA1D | 146 | 210960_at | -0.3262 | 0.0317 | |
| GSE38129 | ADRA1D | 146 | 210960_at | -0.2201 | 0.0009 | |
| GSE45670 | ADRA1D | 146 | 210960_at | 0.0019 | 0.9869 | |
| GSE53622 | ADRA1D | 146 | 132752 | 0.2279 | 0.1489 | |
| GSE53624 | ADRA1D | 146 | 132752 | 0.2846 | 0.0276 | |
| GSE63941 | ADRA1D | 146 | 210961_s_at | 0.1965 | 0.2250 | |
| GSE77861 | ADRA1D | 146 | 210960_at | -0.0799 | 0.4936 | |
| SRP219564 | ADRA1D | 146 | RNAseq | 1.6577 | 0.0551 | |
| TCGA | ADRA1D | 146 | RNAseq | -0.3731 | 0.3081 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ADRA1D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADRA1D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADRA1D | 146 | 13 | 3 | 14 | |
| GSE20123 | ADRA1D | 146 | 14 | 3 | 13 | |
| GSE43470 | ADRA1D | 146 | 10 | 1 | 32 | |
| GSE46452 | ADRA1D | 146 | 26 | 1 | 32 | |
| GSE47630 | ADRA1D | 146 | 18 | 4 | 18 | |
| GSE54993 | ADRA1D | 146 | 2 | 14 | 54 | |
| GSE54994 | ADRA1D | 146 | 24 | 2 | 27 | |
| GSE60625 | ADRA1D | 146 | 0 | 0 | 11 | |
| GSE74703 | ADRA1D | 146 | 9 | 1 | 26 | |
| GSE74704 | ADRA1D | 146 | 9 | 1 | 10 | |
| TCGA | ADRA1D | 146 | 39 | 11 | 46 |
Total number of gains: 164; Total number of losses: 41; Total Number of normals: 283.
Somatic mutations of ADRA1D:
Generating mutation plots.
Highly correlated genes for ADRA1D:
Showing top 20/540 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADRA1D | ART1 | 0.700099 | 3 | 0 | 3 |
| ADRA1D | ACSM5 | 0.699871 | 3 | 0 | 3 |
| ADRA1D | RABEP2 | 0.69224 | 3 | 0 | 3 |
| ADRA1D | TM6SF2 | 0.673987 | 5 | 0 | 3 |
| ADRA1D | MAPK3 | 0.661963 | 5 | 0 | 5 |
| ADRA1D | MCHR1 | 0.661767 | 5 | 0 | 5 |
| ADRA1D | TCP10L | 0.660947 | 3 | 0 | 3 |
| ADRA1D | AZU1 | 0.660344 | 5 | 0 | 5 |
| ADRA1D | LZTS1 | 0.653426 | 3 | 0 | 3 |
| ADRA1D | RORC | 0.653099 | 4 | 0 | 3 |
| ADRA1D | CER1 | 0.652328 | 3 | 0 | 3 |
| ADRA1D | GJA3 | 0.651923 | 3 | 0 | 3 |
| ADRA1D | BRINP2 | 0.645402 | 5 | 0 | 5 |
| ADRA1D | FSCN3 | 0.64442 | 4 | 0 | 4 |
| ADRA1D | SSTR4 | 0.641255 | 5 | 0 | 4 |
| ADRA1D | GRAP2 | 0.640859 | 4 | 0 | 3 |
| ADRA1D | DNAI1 | 0.637674 | 3 | 0 | 3 |
| ADRA1D | CELA3B | 0.637483 | 3 | 0 | 3 |
| ADRA1D | PBOV1 | 0.635843 | 3 | 0 | 3 |
| ADRA1D | MAML3 | 0.633059 | 5 | 0 | 5 |
For details and further investigation, click here
