| Full name: insulin like growth factor binding protein 4 | Alias Symbol: IBP4|BP-4|HT29-IGFBP|IGFBP-4 | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 3487 | HGNC ID: HGNC:5473 | Ensembl Gene: ENSG00000141753 | OMIM ID: 146733 |
| Drug and gene relationship at DGIdb | |||
Expression of IGFBP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IGFBP4 | 3487 | 201508_at | 0.1876 | 0.7946 | |
| GSE20347 | IGFBP4 | 3487 | 201508_at | 1.0013 | 0.0002 | |
| GSE23400 | IGFBP4 | 3487 | 201508_at | 0.4265 | 0.0019 | |
| GSE26886 | IGFBP4 | 3487 | 201508_at | 0.8218 | 0.0034 | |
| GSE29001 | IGFBP4 | 3487 | 201508_at | 0.3181 | 0.2270 | |
| GSE38129 | IGFBP4 | 3487 | 201508_at | 0.5069 | 0.0601 | |
| GSE45670 | IGFBP4 | 3487 | 201508_at | -0.3804 | 0.1648 | |
| GSE53622 | IGFBP4 | 3487 | 58882 | -0.0874 | 0.5370 | |
| GSE53624 | IGFBP4 | 3487 | 58882 | 0.2178 | 0.0755 | |
| GSE63941 | IGFBP4 | 3487 | 201508_at | -3.2219 | 0.0118 | |
| GSE77861 | IGFBP4 | 3487 | 201508_at | 1.1485 | 0.0248 | |
| GSE97050 | IGFBP4 | 3487 | A_24_P382187 | 0.6188 | 0.1380 | |
| SRP007169 | IGFBP4 | 3487 | RNAseq | 1.7055 | 0.0000 | |
| SRP008496 | IGFBP4 | 3487 | RNAseq | 1.6842 | 0.0000 | |
| SRP064894 | IGFBP4 | 3487 | RNAseq | 0.5957 | 0.0368 | |
| SRP133303 | IGFBP4 | 3487 | RNAseq | -0.1405 | 0.6392 | |
| SRP159526 | IGFBP4 | 3487 | RNAseq | 1.0723 | 0.0233 | |
| SRP193095 | IGFBP4 | 3487 | RNAseq | 0.9474 | 0.0012 | |
| SRP219564 | IGFBP4 | 3487 | RNAseq | 0.8929 | 0.3075 | |
| TCGA | IGFBP4 | 3487 | RNAseq | -0.1087 | 0.1576 |
Upregulated datasets: 5; Downregulated datasets: 1.
Survival by IGFBP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IGFBP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IGFBP4 | 3487 | 7 | 1 | 22 | |
| GSE20123 | IGFBP4 | 3487 | 7 | 1 | 22 | |
| GSE43470 | IGFBP4 | 3487 | 1 | 2 | 40 | |
| GSE46452 | IGFBP4 | 3487 | 34 | 0 | 25 | |
| GSE47630 | IGFBP4 | 3487 | 8 | 1 | 31 | |
| GSE54993 | IGFBP4 | 3487 | 3 | 4 | 63 | |
| GSE54994 | IGFBP4 | 3487 | 8 | 5 | 40 | |
| GSE60625 | IGFBP4 | 3487 | 4 | 0 | 7 | |
| GSE74703 | IGFBP4 | 3487 | 1 | 1 | 34 | |
| GSE74704 | IGFBP4 | 3487 | 5 | 1 | 14 | |
| TCGA | IGFBP4 | 3487 | 24 | 8 | 64 |
Total number of gains: 102; Total number of losses: 24; Total Number of normals: 362.
Somatic mutations of IGFBP4:
Generating mutation plots.
Highly correlated genes for IGFBP4:
Showing top 20/1185 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IGFBP4 | TP53I13 | 0.786057 | 3 | 0 | 3 |
| IGFBP4 | RILPL1 | 0.749008 | 3 | 0 | 3 |
| IGFBP4 | GCLC | 0.748028 | 3 | 0 | 3 |
| IGFBP4 | PTCD3 | 0.746918 | 3 | 0 | 3 |
| IGFBP4 | WDR81 | 0.744763 | 3 | 0 | 3 |
| IGFBP4 | TMED8 | 0.74189 | 3 | 0 | 3 |
| IGFBP4 | PIGS | 0.725974 | 3 | 0 | 3 |
| IGFBP4 | TTL | 0.725603 | 3 | 0 | 3 |
| IGFBP4 | FSTL1 | 0.718683 | 12 | 0 | 12 |
| IGFBP4 | ENTPD4 | 0.713357 | 4 | 0 | 4 |
| IGFBP4 | C11orf96 | 0.708319 | 4 | 0 | 4 |
| IGFBP4 | FMNL2 | 0.707844 | 3 | 0 | 3 |
| IGFBP4 | NVL | 0.707118 | 3 | 0 | 3 |
| IGFBP4 | C20orf194 | 0.703952 | 3 | 0 | 3 |
| IGFBP4 | FCGR2C | 0.702169 | 3 | 0 | 3 |
| IGFBP4 | HPCAL1 | 0.699889 | 6 | 0 | 6 |
| IGFBP4 | MRM1 | 0.697415 | 3 | 0 | 3 |
| IGFBP4 | C4orf48 | 0.696506 | 3 | 0 | 3 |
| IGFBP4 | FBLIM1 | 0.695847 | 3 | 0 | 3 |
| IGFBP4 | ANXA6 | 0.69219 | 11 | 0 | 11 |
For details and further investigation, click here
