| Full name: tubulin tyrosine ligase | Alias Symbol: MGC46235 | ||
| Type: protein-coding gene | Cytoband: 2q14.1 | ||
| Entrez ID: 150465 | HGNC ID: HGNC:21586 | Ensembl Gene: ENSG00000114999 | OMIM ID: 608291 |
| Drug and gene relationship at DGIdb | |||
Expression of TTL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TTL | 150465 | 224896_s_at | 1.0687 | 0.0494 | |
| GSE26886 | TTL | 150465 | 224896_s_at | 0.6540 | 0.0041 | |
| GSE45670 | TTL | 150465 | 224896_s_at | 0.8642 | 0.0006 | |
| GSE53622 | TTL | 150465 | 93876 | 0.5886 | 0.0000 | |
| GSE53624 | TTL | 150465 | 93876 | 1.0581 | 0.0000 | |
| GSE63941 | TTL | 150465 | 224896_s_at | -1.3950 | 0.0476 | |
| GSE77861 | TTL | 150465 | 224896_s_at | 1.4206 | 0.0015 | |
| GSE97050 | TTL | 150465 | A_33_P3427102 | 0.3237 | 0.4074 | |
| SRP007169 | TTL | 150465 | RNAseq | 1.4319 | 0.0000 | |
| SRP008496 | TTL | 150465 | RNAseq | 1.6760 | 0.0000 | |
| SRP064894 | TTL | 150465 | RNAseq | 0.9524 | 0.0000 | |
| SRP133303 | TTL | 150465 | RNAseq | 0.7200 | 0.0000 | |
| SRP159526 | TTL | 150465 | RNAseq | 0.8708 | 0.0006 | |
| SRP193095 | TTL | 150465 | RNAseq | 0.7344 | 0.0000 | |
| SRP219564 | TTL | 150465 | RNAseq | 0.1269 | 0.6920 | |
| TCGA | TTL | 150465 | RNAseq | 0.1807 | 0.0014 |
Upregulated datasets: 5; Downregulated datasets: 1.
Survival by TTL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTL | 150465 | 6 | 2 | 22 | |
| GSE20123 | TTL | 150465 | 6 | 2 | 22 | |
| GSE43470 | TTL | 150465 | 3 | 1 | 39 | |
| GSE46452 | TTL | 150465 | 1 | 4 | 54 | |
| GSE47630 | TTL | 150465 | 7 | 0 | 33 | |
| GSE54993 | TTL | 150465 | 0 | 6 | 64 | |
| GSE54994 | TTL | 150465 | 10 | 0 | 43 | |
| GSE60625 | TTL | 150465 | 0 | 3 | 8 | |
| GSE74703 | TTL | 150465 | 3 | 1 | 32 | |
| GSE74704 | TTL | 150465 | 3 | 2 | 15 | |
| TCGA | TTL | 150465 | 31 | 6 | 59 |
Total number of gains: 70; Total number of losses: 27; Total Number of normals: 391.
Somatic mutations of TTL:
Generating mutation plots.
Highly correlated genes for TTL:
Showing top 20/1806 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTL | CDCA2 | 0.830485 | 4 | 0 | 4 |
| TTL | TUBA1B | 0.804472 | 4 | 0 | 4 |
| TTL | HHEX | 0.795924 | 3 | 0 | 3 |
| TTL | ARPC1B | 0.788935 | 7 | 0 | 7 |
| TTL | CDC25B | 0.781221 | 6 | 0 | 6 |
| TTL | GINS4 | 0.779724 | 3 | 0 | 3 |
| TTL | CEP55 | 0.777528 | 6 | 0 | 6 |
| TTL | FADS1 | 0.77386 | 3 | 0 | 3 |
| TTL | XPO1 | 0.771998 | 6 | 0 | 6 |
| TTL | DTYMK | 0.768706 | 6 | 0 | 6 |
| TTL | VPS13C | 0.764537 | 3 | 0 | 3 |
| TTL | RPL39L | 0.761686 | 7 | 0 | 7 |
| TTL | NPHP3 | 0.761589 | 3 | 0 | 3 |
| TTL | PFDN2 | 0.761293 | 7 | 0 | 7 |
| TTL | AIMP2 | 0.761024 | 5 | 0 | 5 |
| TTL | NUP107 | 0.759792 | 7 | 0 | 7 |
| TTL | POLR2D | 0.757958 | 6 | 0 | 6 |
| TTL | USP39 | 0.756119 | 6 | 0 | 6 |
| TTL | XPR1 | 0.755653 | 7 | 0 | 7 |
| TTL | SLC25A32 | 0.754973 | 7 | 0 | 7 |
For details and further investigation, click here
