| Full name: glutamate-cysteine ligase catalytic subunit | Alias Symbol: GCS | ||
| Type: protein-coding gene | Cytoband: 6p12.1 | ||
| Entrez ID: 2729 | HGNC ID: HGNC:4311 | Ensembl Gene: ENSG00000001084 | OMIM ID: 606857 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of GCLC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GCLC | 2729 | 202923_s_at | 0.6125 | 0.3012 | |
| GSE20347 | GCLC | 2729 | 202923_s_at | 0.9049 | 0.0191 | |
| GSE23400 | GCLC | 2729 | 202923_s_at | 0.8939 | 0.0000 | |
| GSE26886 | GCLC | 2729 | 202922_at | -0.1945 | 0.6447 | |
| GSE29001 | GCLC | 2729 | 202922_at | 0.0699 | 0.9001 | |
| GSE38129 | GCLC | 2729 | 202923_s_at | 0.9832 | 0.0015 | |
| GSE45670 | GCLC | 2729 | 202923_s_at | 0.4821 | 0.2235 | |
| GSE53622 | GCLC | 2729 | 108565 | 0.1539 | 0.3583 | |
| GSE53624 | GCLC | 2729 | 108565 | 0.4515 | 0.0000 | |
| GSE63941 | GCLC | 2729 | 202923_s_at | 0.9013 | 0.4080 | |
| GSE77861 | GCLC | 2729 | 202923_s_at | 1.6859 | 0.0023 | |
| GSE97050 | GCLC | 2729 | A_23_P145114 | -0.0852 | 0.8245 | |
| SRP007169 | GCLC | 2729 | RNAseq | 1.7081 | 0.0009 | |
| SRP008496 | GCLC | 2729 | RNAseq | 1.8017 | 0.0000 | |
| SRP064894 | GCLC | 2729 | RNAseq | 0.2436 | 0.4645 | |
| SRP133303 | GCLC | 2729 | RNAseq | 0.7665 | 0.0003 | |
| SRP159526 | GCLC | 2729 | RNAseq | 1.4473 | 0.0100 | |
| SRP193095 | GCLC | 2729 | RNAseq | 0.9025 | 0.0028 | |
| TCGA | GCLC | 2729 | RNAseq | 0.1440 | 0.1698 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by GCLC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GCLC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GCLC | 2729 | 7 | 2 | 21 | |
| GSE20123 | GCLC | 2729 | 7 | 2 | 21 | |
| GSE43470 | GCLC | 2729 | 5 | 0 | 38 | |
| GSE46452 | GCLC | 2729 | 2 | 10 | 47 | |
| GSE47630 | GCLC | 2729 | 7 | 5 | 28 | |
| GSE54993 | GCLC | 2729 | 3 | 1 | 66 | |
| GSE54994 | GCLC | 2729 | 8 | 4 | 41 | |
| GSE60625 | GCLC | 2729 | 0 | 3 | 8 | |
| GSE74703 | GCLC | 2729 | 5 | 0 | 31 | |
| GSE74704 | GCLC | 2729 | 2 | 1 | 17 | |
| TCGA | GCLC | 2729 | 22 | 14 | 60 |
Total number of gains: 68; Total number of losses: 42; Total Number of normals: 378.
Somatic mutations of GCLC:
Generating mutation plots.
Highly correlated genes for GCLC:
Showing top 20/729 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GCLC | HEXA | 0.794442 | 3 | 0 | 3 |
| GCLC | SPRED1 | 0.788523 | 3 | 0 | 3 |
| GCLC | KLHL5 | 0.785735 | 3 | 0 | 3 |
| GCLC | IL13RA2 | 0.771685 | 3 | 0 | 3 |
| GCLC | PARVB | 0.769982 | 3 | 0 | 3 |
| GCLC | IL1B | 0.764969 | 3 | 0 | 3 |
| GCLC | WDR35 | 0.762843 | 3 | 0 | 3 |
| GCLC | NUDT4 | 0.757645 | 3 | 0 | 3 |
| GCLC | ZNF3 | 0.754549 | 3 | 0 | 3 |
| GCLC | IGFBP4 | 0.748028 | 3 | 0 | 3 |
| GCLC | MED10 | 0.744543 | 3 | 0 | 3 |
| GCLC | SHISA2 | 0.741241 | 3 | 0 | 3 |
| GCLC | LITAF | 0.736948 | 3 | 0 | 3 |
| GCLC | HMG20A | 0.734813 | 3 | 0 | 3 |
| GCLC | RFTN2 | 0.73432 | 4 | 0 | 4 |
| GCLC | BOLA1 | 0.731813 | 3 | 0 | 3 |
| GCLC | XPO7 | 0.729735 | 4 | 0 | 3 |
| GCLC | ZC3H12C | 0.724 | 3 | 0 | 3 |
| GCLC | TOR1A | 0.72119 | 4 | 0 | 3 |
| GCLC | FAM120B | 0.720188 | 3 | 0 | 3 |
For details and further investigation, click here
