| Full name: mitochondrial rRNA methyltransferase 1 | Alias Symbol: FLJ22578 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 79922 | HGNC ID: HGNC:26202 | Ensembl Gene: ENSG00000278619 | OMIM ID: 618099 |
| Drug and gene relationship at DGIdb | |||
Expression of MRM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRM1 | 79922 | 219967_at | 0.0962 | 0.6940 | |
| GSE20347 | MRM1 | 79922 | 219967_at | 0.0492 | 0.5556 | |
| GSE23400 | MRM1 | 79922 | 219967_at | 0.2283 | 0.0000 | |
| GSE26886 | MRM1 | 79922 | 219967_at | 0.0448 | 0.7203 | |
| GSE29001 | MRM1 | 79922 | 219967_at | 0.0383 | 0.8276 | |
| GSE38129 | MRM1 | 79922 | 219967_at | -0.0280 | 0.7309 | |
| GSE45670 | MRM1 | 79922 | 219967_at | 0.2085 | 0.0420 | |
| GSE53622 | MRM1 | 79922 | 46634 | 0.1982 | 0.0296 | |
| GSE53624 | MRM1 | 79922 | 46634 | 0.4415 | 0.0000 | |
| GSE63941 | MRM1 | 79922 | 219967_at | 0.3167 | 0.1865 | |
| GSE77861 | MRM1 | 79922 | 219967_at | 0.0404 | 0.7392 | |
| GSE97050 | MRM1 | 79922 | A_23_P15603 | -0.0154 | 0.9653 | |
| SRP007169 | MRM1 | 79922 | RNAseq | 1.0876 | 0.0428 | |
| SRP008496 | MRM1 | 79922 | RNAseq | 0.6050 | 0.0982 | |
| SRP064894 | MRM1 | 79922 | RNAseq | 1.0156 | 0.0001 | |
| SRP133303 | MRM1 | 79922 | RNAseq | 0.3359 | 0.0444 | |
| SRP159526 | MRM1 | 79922 | RNAseq | 0.8736 | 0.0077 | |
| SRP193095 | MRM1 | 79922 | RNAseq | 0.3493 | 0.0066 | |
| SRP219564 | MRM1 | 79922 | RNAseq | 0.1750 | 0.6855 | |
| TCGA | MRM1 | 79922 | RNAseq | 0.2783 | 0.0057 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by MRM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRM1 | 79922 | 5 | 1 | 24 | |
| GSE20123 | MRM1 | 79922 | 5 | 1 | 24 | |
| GSE43470 | MRM1 | 79922 | 1 | 2 | 40 | |
| GSE46452 | MRM1 | 79922 | 34 | 0 | 25 | |
| GSE47630 | MRM1 | 79922 | 8 | 1 | 31 | |
| GSE54993 | MRM1 | 79922 | 3 | 3 | 64 | |
| GSE54994 | MRM1 | 79922 | 8 | 6 | 39 | |
| GSE60625 | MRM1 | 79922 | 4 | 0 | 7 | |
| GSE74703 | MRM1 | 79922 | 1 | 1 | 34 | |
| GSE74704 | MRM1 | 79922 | 3 | 1 | 16 | |
| TCGA | MRM1 | 79922 | 19 | 9 | 68 |
Total number of gains: 91; Total number of losses: 25; Total Number of normals: 372.
Somatic mutations of MRM1:
Generating mutation plots.
Highly correlated genes for MRM1:
Showing top 20/171 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRM1 | NFATC1 | 0.760986 | 3 | 0 | 3 |
| MRM1 | DTYMK | 0.750382 | 3 | 0 | 3 |
| MRM1 | MRPL37 | 0.740652 | 3 | 0 | 3 |
| MRM1 | RPS19BP1 | 0.739227 | 3 | 0 | 3 |
| MRM1 | CPT1C | 0.738977 | 3 | 0 | 3 |
| MRM1 | MKS1 | 0.73729 | 3 | 0 | 3 |
| MRM1 | RFTN2 | 0.730994 | 3 | 0 | 3 |
| MRM1 | C16orf70 | 0.730732 | 3 | 0 | 3 |
| MRM1 | USP39 | 0.728969 | 3 | 0 | 3 |
| MRM1 | GPX1 | 0.727304 | 3 | 0 | 3 |
| MRM1 | GABRA3 | 0.723239 | 3 | 0 | 3 |
| MRM1 | KDM4A | 0.721593 | 3 | 0 | 3 |
| MRM1 | MFHAS1 | 0.717972 | 3 | 0 | 3 |
| MRM1 | CSF3R | 0.717194 | 3 | 0 | 3 |
| MRM1 | ZNF484 | 0.713209 | 3 | 0 | 3 |
| MRM1 | ZBTB39 | 0.710568 | 3 | 0 | 3 |
| MRM1 | PIM2 | 0.703418 | 3 | 0 | 3 |
| MRM1 | PCDH12 | 0.700961 | 4 | 0 | 3 |
| MRM1 | BTBD6 | 0.69931 | 3 | 0 | 3 |
| MRM1 | IL3RA | 0.698589 | 3 | 0 | 3 |
For details and further investigation, click here
