| Full name: interleukin 6 receptor | Alias Symbol: CD126 | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 3570 | HGNC ID: HGNC:6019 | Ensembl Gene: ENSG00000160712 | OMIM ID: 147880 |
| Drug and gene relationship at DGIdb | |||
IL6R involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04066 | HIF-1 signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04630 | Jak-STAT signaling pathway | |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) |
Expression of IL6R:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL6R | 3570 | 226333_at | 0.6824 | 0.5119 | |
| GSE20347 | IL6R | 3570 | 205945_at | 0.0369 | 0.9011 | |
| GSE23400 | IL6R | 3570 | 205945_at | -0.0076 | 0.9347 | |
| GSE26886 | IL6R | 3570 | 226333_at | 0.1293 | 0.7570 | |
| GSE29001 | IL6R | 3570 | 205945_at | 0.1304 | 0.7385 | |
| GSE38129 | IL6R | 3570 | 205945_at | -0.2355 | 0.3143 | |
| GSE45670 | IL6R | 3570 | 226333_at | -0.0455 | 0.8984 | |
| GSE53622 | IL6R | 3570 | 102696 | -0.0723 | 0.5761 | |
| GSE53624 | IL6R | 3570 | 102696 | 0.1490 | 0.0905 | |
| GSE63941 | IL6R | 3570 | 226333_at | -0.6822 | 0.4381 | |
| GSE77861 | IL6R | 3570 | 226333_at | 0.6587 | 0.2050 | |
| GSE97050 | IL6R | A_21_P0000171 | -0.5054 | 0.1923 | ||
| SRP007169 | IL6R | 3570 | RNAseq | 1.0100 | 0.0170 | |
| SRP008496 | IL6R | 3570 | RNAseq | 0.8248 | 0.0094 | |
| SRP064894 | IL6R | 3570 | RNAseq | -0.3007 | 0.2078 | |
| SRP133303 | IL6R | 3570 | RNAseq | 0.2072 | 0.3320 | |
| SRP159526 | IL6R | 3570 | RNAseq | -0.3814 | 0.4828 | |
| SRP193095 | IL6R | 3570 | RNAseq | 0.4006 | 0.0020 | |
| SRP219564 | IL6R | 3570 | RNAseq | 0.5796 | 0.2120 | |
| TCGA | IL6R | 3570 | RNAseq | -0.2708 | 0.0155 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by IL6R expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL6R:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL6R | 3570 | 14 | 0 | 16 | |
| GSE20123 | IL6R | 3570 | 14 | 0 | 16 | |
| GSE43470 | IL6R | 3570 | 6 | 2 | 35 | |
| GSE46452 | IL6R | 3570 | 2 | 1 | 56 | |
| GSE47630 | IL6R | 3570 | 14 | 0 | 26 | |
| GSE54993 | IL6R | 3570 | 0 | 4 | 66 | |
| GSE54994 | IL6R | 3570 | 16 | 0 | 37 | |
| GSE60625 | IL6R | 3570 | 0 | 0 | 11 | |
| GSE74703 | IL6R | 3570 | 6 | 1 | 29 | |
| GSE74704 | IL6R | 3570 | 7 | 0 | 13 | |
| TCGA | IL6R | 3570 | 38 | 2 | 56 |
Total number of gains: 117; Total number of losses: 10; Total Number of normals: 361.
Somatic mutations of IL6R:
Generating mutation plots.
Highly correlated genes for IL6R:
Showing top 20/221 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL6R | CAMKK1 | 0.826266 | 3 | 0 | 3 |
| IL6R | RLIM | 0.815945 | 3 | 0 | 3 |
| IL6R | CLIC2 | 0.79819 | 3 | 0 | 3 |
| IL6R | C2orf69 | 0.774695 | 3 | 0 | 3 |
| IL6R | PPHLN1 | 0.774247 | 3 | 0 | 3 |
| IL6R | ZNF280C | 0.773908 | 3 | 0 | 3 |
| IL6R | EVL | 0.770207 | 3 | 0 | 3 |
| IL6R | DDX59 | 0.765286 | 3 | 0 | 3 |
| IL6R | CDC5L | 0.75922 | 3 | 0 | 3 |
| IL6R | DIP2A | 0.752221 | 3 | 0 | 3 |
| IL6R | ZC3H15 | 0.747433 | 3 | 0 | 3 |
| IL6R | ARL10 | 0.736499 | 3 | 0 | 3 |
| IL6R | ACSL4 | 0.736003 | 3 | 0 | 3 |
| IL6R | SEL1L | 0.734709 | 3 | 0 | 3 |
| IL6R | IQCE | 0.73468 | 3 | 0 | 3 |
| IL6R | TPR | 0.734092 | 3 | 0 | 3 |
| IL6R | REEP5 | 0.731969 | 3 | 0 | 3 |
| IL6R | WDR81 | 0.731049 | 3 | 0 | 3 |
| IL6R | MRPL52 | 0.73097 | 3 | 0 | 3 |
| IL6R | HAUS2 | 0.730373 | 3 | 0 | 3 |
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