| Full name: SEL1L adaptor subunit of ERAD E3 ubiquitin ligase | Alias Symbol: IBD2|SEL1L1|Hrd3 | ||
| Type: protein-coding gene | Cytoband: 14q31 | ||
| Entrez ID: 6400 | HGNC ID: HGNC:10717 | Ensembl Gene: ENSG00000071537 | OMIM ID: 602329 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SEL1L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEL1L | 6400 | 202061_s_at | 0.1744 | 0.6307 | |
| GSE20347 | SEL1L | 6400 | 202061_s_at | 0.3767 | 0.0061 | |
| GSE23400 | SEL1L | 6400 | 202061_s_at | 0.4246 | 0.0000 | |
| GSE26886 | SEL1L | 6400 | 202061_s_at | 0.6308 | 0.0191 | |
| GSE29001 | SEL1L | 6400 | 202061_s_at | 0.4485 | 0.0945 | |
| GSE38129 | SEL1L | 6400 | 202061_s_at | 0.2343 | 0.0597 | |
| GSE45670 | SEL1L | 6400 | 202061_s_at | 0.0370 | 0.8775 | |
| GSE53622 | SEL1L | 6400 | 56437 | 0.6401 | 0.0000 | |
| GSE53624 | SEL1L | 6400 | 77718 | 0.3433 | 0.0000 | |
| GSE63941 | SEL1L | 6400 | 202061_s_at | -1.3286 | 0.0081 | |
| GSE77861 | SEL1L | 6400 | 202061_s_at | 0.3609 | 0.2943 | |
| GSE97050 | SEL1L | 6400 | A_33_P3275968 | 0.1739 | 0.5786 | |
| SRP007169 | SEL1L | 6400 | RNAseq | 0.6825 | 0.0331 | |
| SRP008496 | SEL1L | 6400 | RNAseq | 0.8567 | 0.0004 | |
| SRP064894 | SEL1L | 6400 | RNAseq | 0.4771 | 0.0333 | |
| SRP133303 | SEL1L | 6400 | RNAseq | 0.7761 | 0.0000 | |
| SRP159526 | SEL1L | 6400 | RNAseq | 0.4080 | 0.1603 | |
| SRP193095 | SEL1L | 6400 | RNAseq | 0.2034 | 0.2649 | |
| SRP219564 | SEL1L | 6400 | RNAseq | 0.3876 | 0.3998 | |
| TCGA | SEL1L | 6400 | RNAseq | -0.1964 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SEL1L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEL1L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEL1L | 6400 | 9 | 3 | 18 | |
| GSE20123 | SEL1L | 6400 | 9 | 3 | 18 | |
| GSE43470 | SEL1L | 6400 | 8 | 3 | 32 | |
| GSE46452 | SEL1L | 6400 | 16 | 3 | 40 | |
| GSE47630 | SEL1L | 6400 | 11 | 8 | 21 | |
| GSE54993 | SEL1L | 6400 | 3 | 8 | 59 | |
| GSE54994 | SEL1L | 6400 | 19 | 4 | 30 | |
| GSE60625 | SEL1L | 6400 | 0 | 2 | 9 | |
| GSE74703 | SEL1L | 6400 | 7 | 3 | 26 | |
| GSE74704 | SEL1L | 6400 | 4 | 3 | 13 | |
| TCGA | SEL1L | 6400 | 30 | 19 | 47 |
Total number of gains: 116; Total number of losses: 59; Total Number of normals: 313.
Somatic mutations of SEL1L:
Generating mutation plots.
Highly correlated genes for SEL1L:
Showing top 20/983 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEL1L | KBTBD6 | 0.747501 | 3 | 0 | 3 |
| SEL1L | CCDC91 | 0.739824 | 6 | 0 | 5 |
| SEL1L | JKAMP | 0.737034 | 5 | 0 | 5 |
| SEL1L | IL6R | 0.734709 | 3 | 0 | 3 |
| SEL1L | DHX36 | 0.734041 | 3 | 0 | 3 |
| SEL1L | CCT8 | 0.702275 | 3 | 0 | 3 |
| SEL1L | DR1 | 0.702237 | 4 | 0 | 3 |
| SEL1L | SCAMP1 | 0.696462 | 4 | 0 | 4 |
| SEL1L | KATNA1 | 0.695709 | 4 | 0 | 4 |
| SEL1L | SRSF10 | 0.694625 | 4 | 0 | 4 |
| SEL1L | RBM7 | 0.690185 | 3 | 0 | 3 |
| SEL1L | DDHD1 | 0.688901 | 5 | 0 | 5 |
| SEL1L | PTGFRN | 0.68705 | 5 | 0 | 5 |
| SEL1L | PDIA5 | 0.686867 | 3 | 0 | 3 |
| SEL1L | DHX15 | 0.686676 | 4 | 0 | 3 |
| SEL1L | C15orf61 | 0.685523 | 3 | 0 | 3 |
| SEL1L | KLHL36 | 0.683829 | 4 | 0 | 3 |
| SEL1L | PRKAR1A | 0.68264 | 3 | 0 | 3 |
| SEL1L | DOCK7 | 0.682052 | 6 | 0 | 5 |
| SEL1L | FAM126A | 0.679911 | 3 | 0 | 3 |
For details and further investigation, click here
