| Full name: calcium/calmodulin dependent protein kinase kinase 1 | Alias Symbol: DKFZp761M0423|CAMKKA|MGC34095 | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 84254 | HGNC ID: HGNC:1469 | Ensembl Gene: ENSG00000004660 | OMIM ID: 611411 |
| Drug and gene relationship at DGIdb | |||
CAMKK1 involved pathways:
Expression of CAMKK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CAMKK1 | 84254 | 223460_at | 0.3589 | 0.3867 | |
| GSE26886 | CAMKK1 | 84254 | 223460_at | 0.5202 | 0.0004 | |
| GSE45670 | CAMKK1 | 84254 | 223460_at | 0.1698 | 0.2683 | |
| GSE53622 | CAMKK1 | 84254 | 111698 | 0.1912 | 0.3551 | |
| GSE53624 | CAMKK1 | 84254 | 111698 | 0.4326 | 0.0026 | |
| GSE63941 | CAMKK1 | 84254 | 223460_at | 0.2880 | 0.1754 | |
| GSE77861 | CAMKK1 | 84254 | 223460_at | 0.1250 | 0.3761 | |
| GSE97050 | CAMKK1 | 84254 | A_24_P292929 | -0.1017 | 0.7175 | |
| SRP007169 | CAMKK1 | 84254 | RNAseq | 0.4885 | 0.3020 | |
| SRP008496 | CAMKK1 | 84254 | RNAseq | 0.9700 | 0.0095 | |
| SRP064894 | CAMKK1 | 84254 | RNAseq | 0.2570 | 0.2000 | |
| SRP133303 | CAMKK1 | 84254 | RNAseq | 0.0018 | 0.9947 | |
| SRP159526 | CAMKK1 | 84254 | RNAseq | 0.5296 | 0.2381 | |
| SRP193095 | CAMKK1 | 84254 | RNAseq | 0.9016 | 0.0000 | |
| SRP219564 | CAMKK1 | 84254 | RNAseq | 0.8620 | 0.1125 | |
| TCGA | CAMKK1 | 84254 | RNAseq | 0.3065 | 0.0038 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CAMKK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CAMKK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CAMKK1 | 84254 | 5 | 3 | 22 | |
| GSE20123 | CAMKK1 | 84254 | 5 | 4 | 21 | |
| GSE43470 | CAMKK1 | 84254 | 1 | 6 | 36 | |
| GSE46452 | CAMKK1 | 84254 | 34 | 1 | 24 | |
| GSE47630 | CAMKK1 | 84254 | 7 | 1 | 32 | |
| GSE54993 | CAMKK1 | 84254 | 4 | 3 | 63 | |
| GSE54994 | CAMKK1 | 84254 | 5 | 9 | 39 | |
| GSE60625 | CAMKK1 | 84254 | 4 | 0 | 7 | |
| GSE74703 | CAMKK1 | 84254 | 1 | 3 | 32 | |
| GSE74704 | CAMKK1 | 84254 | 3 | 2 | 15 | |
| TCGA | CAMKK1 | 84254 | 18 | 21 | 57 |
Total number of gains: 87; Total number of losses: 53; Total Number of normals: 348.
Somatic mutations of CAMKK1:
Generating mutation plots.
Highly correlated genes for CAMKK1:
Showing top 20/413 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CAMKK1 | IL6R | 0.826266 | 3 | 0 | 3 |
| CAMKK1 | RPTOR | 0.817241 | 3 | 0 | 3 |
| CAMKK1 | TLK1 | 0.802033 | 3 | 0 | 3 |
| CAMKK1 | LRP5L | 0.78041 | 3 | 0 | 3 |
| CAMKK1 | BFSP1 | 0.762908 | 4 | 0 | 4 |
| CAMKK1 | NACC1 | 0.762608 | 3 | 0 | 3 |
| CAMKK1 | DCUN1D2 | 0.75833 | 3 | 0 | 3 |
| CAMKK1 | INO80E | 0.757407 | 3 | 0 | 3 |
| CAMKK1 | XYLT2 | 0.753929 | 4 | 0 | 4 |
| CAMKK1 | SNTA1 | 0.747293 | 3 | 0 | 3 |
| CAMKK1 | HCFC1R1 | 0.743451 | 3 | 0 | 3 |
| CAMKK1 | SMYD2 | 0.743422 | 3 | 0 | 3 |
| CAMKK1 | MYH10 | 0.73818 | 4 | 0 | 4 |
| CAMKK1 | PHRF1 | 0.734124 | 3 | 0 | 3 |
| CAMKK1 | ROMO1 | 0.733433 | 3 | 0 | 3 |
| CAMKK1 | MED22 | 0.732074 | 3 | 0 | 3 |
| CAMKK1 | SLC41A1 | 0.731329 | 3 | 0 | 3 |
| CAMKK1 | MMP15 | 0.730311 | 3 | 0 | 3 |
| CAMKK1 | DGKD | 0.729989 | 4 | 0 | 4 |
| CAMKK1 | SIX5 | 0.72543 | 4 | 0 | 3 |
For details and further investigation, click here
