| Full name: acyl-CoA synthetase long chain family member 4 | Alias Symbol: ACS4|LACS4 | ||
| Type: protein-coding gene | Cytoband: Xq23 | ||
| Entrez ID: 2182 | HGNC ID: HGNC:3571 | Ensembl Gene: ENSG00000068366 | OMIM ID: 300157 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ACSL4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway | |
| hsa04920 | Adipocytokine signaling pathway |
Expression of ACSL4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACSL4 | 2182 | 202422_s_at | 0.1307 | 0.8002 | |
| GSE20347 | ACSL4 | 2182 | 202422_s_at | 0.4910 | 0.0690 | |
| GSE23400 | ACSL4 | 2182 | 202422_s_at | 0.5163 | 0.0000 | |
| GSE26886 | ACSL4 | 2182 | 202422_s_at | 0.6500 | 0.0688 | |
| GSE29001 | ACSL4 | 2182 | 202422_s_at | 0.6466 | 0.0520 | |
| GSE38129 | ACSL4 | 2182 | 202422_s_at | 0.3905 | 0.0842 | |
| GSE45670 | ACSL4 | 2182 | 202422_s_at | 0.0336 | 0.9477 | |
| GSE53622 | ACSL4 | 2182 | 27075 | 0.5533 | 0.0000 | |
| GSE53624 | ACSL4 | 2182 | 27075 | 0.4363 | 0.0001 | |
| GSE63941 | ACSL4 | 2182 | 202422_s_at | -3.1389 | 0.0007 | |
| GSE77861 | ACSL4 | 2182 | 202422_s_at | 0.3563 | 0.4497 | |
| GSE97050 | ACSL4 | 2182 | A_23_P217564 | 0.6652 | 0.1069 | |
| SRP007169 | ACSL4 | 2182 | RNAseq | 1.9024 | 0.0000 | |
| SRP008496 | ACSL4 | 2182 | RNAseq | 2.1300 | 0.0000 | |
| SRP064894 | ACSL4 | 2182 | RNAseq | 0.6440 | 0.0499 | |
| SRP133303 | ACSL4 | 2182 | RNAseq | 0.7253 | 0.0000 | |
| SRP159526 | ACSL4 | 2182 | RNAseq | 0.6293 | 0.0628 | |
| SRP193095 | ACSL4 | 2182 | RNAseq | 0.8266 | 0.0000 | |
| SRP219564 | ACSL4 | 2182 | RNAseq | 0.9911 | 0.0141 | |
| TCGA | ACSL4 | 2182 | RNAseq | -0.0458 | 0.4936 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by ACSL4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACSL4:
No record found for this gene.
Somatic mutations of ACSL4:
Generating mutation plots.
Highly correlated genes for ACSL4:
Showing top 20/690 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACSL4 | A1BG | 0.795885 | 3 | 0 | 3 |
| ACSL4 | TNFRSF19 | 0.784483 | 3 | 0 | 3 |
| ACSL4 | ANAPC4 | 0.778581 | 3 | 0 | 3 |
| ACSL4 | PLEKHG2 | 0.752838 | 3 | 0 | 3 |
| ACSL4 | HARS2 | 0.746054 | 3 | 0 | 3 |
| ACSL4 | PDCD2L | 0.740965 | 3 | 0 | 3 |
| ACSL4 | IL6R | 0.736003 | 3 | 0 | 3 |
| ACSL4 | SLC39A10 | 0.732465 | 5 | 0 | 5 |
| ACSL4 | SUMF2 | 0.724721 | 3 | 0 | 3 |
| ACSL4 | EIF4G3 | 0.721029 | 4 | 0 | 3 |
| ACSL4 | SLC30A5 | 0.718425 | 3 | 0 | 3 |
| ACSL4 | ZBTB9 | 0.704228 | 3 | 0 | 3 |
| ACSL4 | PIGL | 0.70025 | 3 | 0 | 3 |
| ACSL4 | KREMEN1 | 0.698686 | 3 | 0 | 3 |
| ACSL4 | FLNB | 0.687841 | 3 | 0 | 3 |
| ACSL4 | PRSS12 | 0.681964 | 3 | 0 | 3 |
| ACSL4 | OSBPL6 | 0.681127 | 3 | 0 | 3 |
| ACSL4 | CEP170 | 0.675852 | 3 | 0 | 3 |
| ACSL4 | TMX3 | 0.673758 | 4 | 0 | 3 |
| ACSL4 | USP32 | 0.671917 | 4 | 0 | 4 |
For details and further investigation, click here
