| Full name: mitochondrial ribosomal protein L52 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 122704 | HGNC ID: HGNC:16655 | Ensembl Gene: ENSG00000172590 | OMIM ID: 611856 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MRPL52:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL52 | 122704 | 226241_s_at | 0.2468 | 0.7520 | |
| GSE20347 | MRPL52 | 122704 | 221997_s_at | 0.2263 | 0.1250 | |
| GSE23400 | MRPL52 | 122704 | 221997_s_at | 0.0713 | 0.0735 | |
| GSE26886 | MRPL52 | 122704 | 226241_s_at | 1.0381 | 0.0002 | |
| GSE29001 | MRPL52 | 122704 | 221997_s_at | 0.1215 | 0.6642 | |
| GSE38129 | MRPL52 | 122704 | 221997_s_at | 0.2609 | 0.2647 | |
| GSE45670 | MRPL52 | 122704 | 226241_s_at | 0.3886 | 0.0062 | |
| GSE53622 | MRPL52 | 122704 | 7500 | 0.2247 | 0.0107 | |
| GSE53624 | MRPL52 | 122704 | 7500 | 0.4403 | 0.0000 | |
| GSE63941 | MRPL52 | 122704 | 226241_s_at | 0.5123 | 0.4110 | |
| GSE77861 | MRPL52 | 122704 | 226241_s_at | -0.0489 | 0.8993 | |
| GSE97050 | MRPL52 | 122704 | A_24_P409330 | 0.3559 | 0.1769 | |
| SRP007169 | MRPL52 | 122704 | RNAseq | -0.0359 | 0.9244 | |
| SRP008496 | MRPL52 | 122704 | RNAseq | -0.1822 | 0.4338 | |
| SRP064894 | MRPL52 | 122704 | RNAseq | 0.6572 | 0.0587 | |
| SRP133303 | MRPL52 | 122704 | RNAseq | 0.4773 | 0.0254 | |
| SRP159526 | MRPL52 | 122704 | RNAseq | 0.0457 | 0.8444 | |
| SRP193095 | MRPL52 | 122704 | RNAseq | -0.0528 | 0.6988 | |
| SRP219564 | MRPL52 | 122704 | RNAseq | 0.3439 | 0.3046 | |
| TCGA | MRPL52 | 122704 | RNAseq | 0.1178 | 0.0852 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MRPL52 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPL52:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL52 | 122704 | 9 | 2 | 19 | |
| GSE20123 | MRPL52 | 122704 | 9 | 2 | 19 | |
| GSE43470 | MRPL52 | 122704 | 7 | 2 | 34 | |
| GSE46452 | MRPL52 | 122704 | 17 | 2 | 40 | |
| GSE47630 | MRPL52 | 122704 | 11 | 10 | 19 | |
| GSE54993 | MRPL52 | 122704 | 3 | 11 | 56 | |
| GSE54994 | MRPL52 | 122704 | 18 | 5 | 30 | |
| GSE60625 | MRPL52 | 122704 | 0 | 2 | 9 | |
| GSE74703 | MRPL52 | 122704 | 6 | 2 | 28 | |
| GSE74704 | MRPL52 | 122704 | 4 | 1 | 15 | |
| TCGA | MRPL52 | 122704 | 26 | 16 | 54 |
Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.
Somatic mutations of MRPL52:
Generating mutation plots.
Highly correlated genes for MRPL52:
Showing top 20/620 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL52 | NEDD8 | 0.770168 | 8 | 0 | 8 |
| MRPL52 | KIAA0319L | 0.763908 | 3 | 0 | 3 |
| MRPL52 | ENOSF1 | 0.761173 | 3 | 0 | 3 |
| MRPL52 | PGAP1 | 0.756885 | 3 | 0 | 3 |
| MRPL52 | YES1 | 0.752696 | 4 | 0 | 4 |
| MRPL52 | NEK6 | 0.742786 | 3 | 0 | 3 |
| MRPL52 | KHSRP | 0.741931 | 3 | 0 | 3 |
| MRPL52 | THOC1 | 0.73641 | 4 | 0 | 4 |
| MRPL52 | IL6R | 0.73097 | 3 | 0 | 3 |
| MRPL52 | NOC2L | 0.730036 | 3 | 0 | 3 |
| MRPL52 | SLC7A6OS | 0.725914 | 3 | 0 | 3 |
| MRPL52 | GTF2F2 | 0.725447 | 3 | 0 | 3 |
| MRPL52 | CD44 | 0.724127 | 3 | 0 | 3 |
| MRPL52 | TUBA1B | 0.722897 | 3 | 0 | 3 |
| MRPL52 | CEP250 | 0.720472 | 3 | 0 | 3 |
| MRPL52 | TCF20 | 0.719209 | 3 | 0 | 3 |
| MRPL52 | POU3F4 | 0.715626 | 3 | 0 | 3 |
| MRPL52 | EBNA1BP2 | 0.714932 | 3 | 0 | 3 |
| MRPL52 | IPO4 | 0.714853 | 11 | 0 | 10 |
| MRPL52 | DAD1 | 0.711049 | 8 | 0 | 7 |
For details and further investigation, click here
