Full name: translocated promoter region, nuclear basket protein	Alias Symbol:
Type: protein-coding gene	Cytoband: 1q31.1
Entrez ID: 7175	HGNC ID: HGNC:12017	Ensembl Gene: ENSG00000047410	OMIM ID: 189940
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 260/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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TPR involved pathways:

KEGG pathway	Description	View
hsa05200	Pathways in cancer	View
hsa05216	Thyroid cancer	View

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Expression of TPR:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	TPR	7175	201730_s_at	0.4634	0.4578	Show
GSE20347	TPR	7175	201730_s_at	0.4804	0.0084	Show
GSE23400	TPR	7175	201731_s_at	0.4488	0.0000	Show
GSE26886	TPR	7175	201730_s_at	-0.0021	0.9954	Show
GSE29001	TPR	7175	201730_s_at	0.4172	0.1695	Show
GSE38129	TPR	7175	201730_s_at	0.3419	0.0726	Show
GSE45670	TPR	7175	201731_s_at	0.1657	0.1949	Show
GSE53622	TPR	7175	45103	0.3420	0.0000	Show
GSE53624	TPR	7175	45103	0.4925	0.0000	Show
GSE63941	TPR	7175	201731_s_at	-0.2641	0.6614	Show
GSE77861	TPR	7175	201731_s_at	0.7144	0.0061	Show
GSE97050	TPR	7175	A_24_P179611	0.0235	0.9535	Show
SRP007169	TPR	7175	RNAseq	1.4254	0.0000	Show
SRP008496	TPR	7175	RNAseq	1.6830	0.0000	Show
SRP064894	TPR	7175	RNAseq	0.2710	0.2847	Show
SRP133303	TPR	7175	RNAseq	0.2621	0.0004	Show
SRP159526	TPR	7175	RNAseq	0.3575	0.0153	Show
SRP193095	TPR	7175	RNAseq	0.2704	0.0000	Show
SRP219564	TPR	7175	RNAseq	0.1616	0.4505	Show
TCGA	TPR	7175	RNAseq	0.0472	0.2532	Show

Upregulated datasets: 2; Downregulated datasets: 0.  Download Data

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Survival by TPR expression:

 

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Copy number change of TPR:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	TPR	7175	10	0	20	Show
GSE20123	TPR	7175	10	0	20	Show
GSE43470	TPR	7175	6	1	36	Show
GSE46452	TPR	7175	3	1	55	Show
GSE47630	TPR	7175	14	0	26	Show
GSE54993	TPR	7175	0	6	64	Show
GSE54994	TPR	7175	15	0	38	Show
GSE60625	TPR	7175	0	0	11	Show
GSE74703	TPR	7175	6	1	29	Show
GSE74704	TPR	7175	4	0	16	Show
TCGA	TPR	7175	41	4	51	Show

Total number of gains: 109; Total number of losses: 13; Total Number of normals: 366.  Download Data

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Somatic mutations of TPR:

 

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Highly correlated genes for TPR:

 

Showing top 20/1223 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
TPR	NAA15	0.769683	3	0	3
TPR	RBM34	0.762395	3	0	3
TPR	ZNF567	0.747189	3	0	3
TPR	RNASEH2B	0.736816	4	0	3
TPR	IL17RD	0.735439	3	0	3
TPR	IL6R	0.734092	3	0	3
TPR	ACTRT3	0.731544	3	0	3
TPR	EIF3H	0.730707	3	0	3
TPR	ALKBH6	0.722891	4	0	3
TPR	XPR1	0.720578	5	0	5
TPR	NEDD1	0.715907	6	0	5
TPR	CCDC127	0.711278	3	0	3
TPR	SCARB1	0.709485	3	0	3
TPR	ARID2	0.708029	3	0	3
TPR	EIF5	0.706352	3	0	3
TPR	SSBP4	0.705753	4	0	4
TPR	NOP58	0.703744	7	0	6
TPR	MRPS5	0.701972	3	0	3
TPR	NF1	0.701747	3	0	3
TPR	KRTCAP2	0.701375	5	0	4

For details and further investigation, click here