CLIC2

 

Full name: chloride intracellular channel 2 Alias Symbol: XAP121|CLCNL2
Type: protein-coding gene Cytoband: Xq28
Entrez ID: 1193 HGNC ID: HGNC:2063 Ensembl Gene: ENSG00000155962 OMIM ID: 300138
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CLIC2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CLIC2 1193 213415_at 0.0871 0.9363
GSE20347 CLIC2 1193 213415_at 0.7577 0.0508
GSE23400 CLIC2 1193 213415_at 0.0378 0.6636
GSE26886 CLIC2 1193 213415_at -0.0176 0.9738
GSE29001 CLIC2 1193 213415_at 0.1878 0.6155
GSE38129 CLIC2 1193 213415_at 0.2750 0.4915
GSE45670 CLIC2 1193 213415_at -0.1371 0.7738
GSE53622 CLIC2 1193 34752 -0.3042 0.0636
GSE53624 CLIC2 1193 34752 -0.1063 0.4792
GSE63941 CLIC2 1193 213415_at -1.2183 0.2922
GSE77861 CLIC2 1193 213415_at 0.5472 0.2478
GSE97050 CLIC2 1193 A_33_P3775848 -0.0033 0.9916
SRP007169 CLIC2 1193 RNAseq -0.8369 0.1203
SRP008496 CLIC2 1193 RNAseq -1.3011 0.0021
SRP064894 CLIC2 1193 RNAseq -0.1090 0.6982
SRP133303 CLIC2 1193 RNAseq -0.1831 0.4891
SRP159526 CLIC2 1193 RNAseq 0.0287 0.9263
SRP193095 CLIC2 1193 RNAseq 0.2989 0.1063
SRP219564 CLIC2 1193 RNAseq 0.2182 0.6019
TCGA CLIC2 1193 RNAseq -0.0441 0.7521

Upregulated datasets: 0; Downregulated datasets: 1.  


 

Survival by CLIC2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of CLIC2:

 

No record found for this gene.


 

Somatic mutations of CLIC2:

 

Generating mutation plots.

 

Highly correlated genes for CLIC2:

 

Showing top 20/298 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CLIC2IL6R0.79819303
CLIC2CHN10.736433303
CLIC2CHD10.725567303
CLIC2CDKN1C0.724633303
CLIC2GLIPR10.716929303
CLIC2TTYH20.713475303
CLIC2TNFAIP8L20.708092303
CLIC2UGGT20.68365505
CLIC2PPIG0.682465303
CLIC2LILRB50.678432504
CLIC2C19orf380.675937303
CLIC2ANKRD100.674815403
CLIC2KRTCAP20.674227303
CLIC2DEGS10.671841403
CLIC2ARHGAP150.667765404
CLIC2ZC3H150.665224303
CLIC2CD99L20.662754303
CLIC2GIMAP50.6612403
CLIC2SAMD30.659966403
CLIC2ECSCR0.655651503

For details and further investigation, click here