IRS4

 

Full name: insulin receptor substrate 4 Alias Symbol: PY160|IRS-4
Type: protein-coding gene Cytoband: Xq22.3
Entrez ID: 8471 HGNC ID: HGNC:6128 Ensembl Gene: ENSG00000133124 OMIM ID: 300904
Drug and gene relationship at DGIdb

 

IRS4 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04068FoxO signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04930Type II diabetes mellitus

 

Expression of IRS4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IRS4 8471 207403_at -0.1209 0.6233
GSE20347 IRS4 8471 207403_at -0.1032 0.2855
GSE23400 IRS4 8471 207403_at -0.1250 0.0001
GSE26886 IRS4 8471 207403_at 0.2620 0.0295
GSE29001 IRS4 8471 207403_at -0.0898 0.6140
GSE38129 IRS4 8471 207403_at -0.0825 0.4707
GSE45670 IRS4 8471 207403_at -0.0883 0.3770
GSE53622 IRS4 8471 87735 0.1033 0.5990
GSE53624 IRS4 8471 87735 0.2851 0.0833
GSE63941 IRS4 8471 207403_at 0.0844 0.6278
GSE77861 IRS4 8471 207403_at -0.0416 0.6971
TCGA IRS4 8471 RNAseq 0.0436 0.9645

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by IRS4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IRS4:

 

No record found for this gene.

 

Somatic mutations of IRS4:

 

Generating mutation plots.

 

Highly correlated genes for IRS4:

 

Showing top 20/1036 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IRS4LIPF0.764994303
IRS4CA80.75923303
IRS4AMELX0.74382303
IRS4ASIC40.737615404
IRS4RUNX1T10.725682303
IRS4LRTM10.719604404
IRS4GPD10.71262303
IRS4SCTR0.712466404
IRS4GJB40.711333404
IRS4SIT10.705305303
IRS4CCDC870.704666404
IRS4NPTXR0.704065505
IRS4ACVRL10.703509303
IRS4NMNAT20.699528303
IRS4IL9R0.698014404
IRS4SLC10A20.694458303
IRS4BMP150.692219606
IRS4XPNPEP20.690847403
IRS4NTNG10.688095404
IRS4CCDC70.685517404

For details and further investigation, click here