| Full name: carbonic anhydrase 8 | Alias Symbol: CARP | ||
| Type: protein-coding gene | Cytoband: 8q12.1 | ||
| Entrez ID: 767 | HGNC ID: HGNC:1382 | Ensembl Gene: ENSG00000178538 | OMIM ID: 114815 |
| Drug and gene relationship at DGIdb | |||
Expression of CA8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CA8 | 767 | 220234_at | -0.0643 | 0.8508 | |
| GSE20347 | CA8 | 767 | 220234_at | 0.0682 | 0.5391 | |
| GSE23400 | CA8 | 767 | 220234_at | -0.1283 | 0.0193 | |
| GSE26886 | CA8 | 767 | 220234_at | -0.0135 | 0.9093 | |
| GSE29001 | CA8 | 767 | 220234_at | -0.1984 | 0.1990 | |
| GSE38129 | CA8 | 767 | 220234_at | -0.0949 | 0.4239 | |
| GSE45670 | CA8 | 767 | 220234_at | -0.0276 | 0.9260 | |
| GSE53622 | CA8 | 767 | 35942 | -0.5214 | 0.0347 | |
| GSE53624 | CA8 | 767 | 35942 | -0.5732 | 0.0071 | |
| GSE63941 | CA8 | 767 | 220234_at | 0.7531 | 0.3161 | |
| GSE77861 | CA8 | 767 | 220234_at | -0.0577 | 0.6252 | |
| SRP133303 | CA8 | 767 | RNAseq | -0.6651 | 0.1277 | |
| SRP159526 | CA8 | 767 | RNAseq | 2.1211 | 0.0279 | |
| TCGA | CA8 | 767 | RNAseq | -1.9763 | 0.0004 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by CA8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CA8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CA8 | 767 | 13 | 1 | 16 | |
| GSE20123 | CA8 | 767 | 13 | 1 | 16 | |
| GSE43470 | CA8 | 767 | 14 | 3 | 26 | |
| GSE46452 | CA8 | 767 | 20 | 2 | 37 | |
| GSE47630 | CA8 | 767 | 23 | 1 | 16 | |
| GSE54993 | CA8 | 767 | 1 | 17 | 52 | |
| GSE54994 | CA8 | 767 | 30 | 0 | 23 | |
| GSE60625 | CA8 | 767 | 0 | 4 | 7 | |
| GSE74703 | CA8 | 767 | 12 | 2 | 22 | |
| GSE74704 | CA8 | 767 | 9 | 0 | 11 | |
| TCGA | CA8 | 767 | 46 | 5 | 45 |
Total number of gains: 181; Total number of losses: 36; Total Number of normals: 271.
Somatic mutations of CA8:
Generating mutation plots.
Highly correlated genes for CA8:
Showing top 20/386 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CA8 | SHOX | 0.799648 | 3 | 0 | 3 |
| CA8 | PRPS1L1 | 0.797852 | 3 | 0 | 3 |
| CA8 | IRS4 | 0.75923 | 3 | 0 | 3 |
| CA8 | GPR22 | 0.756573 | 3 | 0 | 3 |
| CA8 | OR3A1 | 0.733666 | 3 | 0 | 3 |
| CA8 | MUC3B | 0.73218 | 3 | 0 | 3 |
| CA8 | TAS2R7 | 0.722194 | 3 | 0 | 3 |
| CA8 | HCRTR2 | 0.711187 | 3 | 0 | 3 |
| CA8 | FNDC8 | 0.711057 | 3 | 0 | 3 |
| CA8 | GPLD1 | 0.707753 | 3 | 0 | 3 |
| CA8 | TAS2R8 | 0.705932 | 3 | 0 | 3 |
| CA8 | HAVCR1 | 0.702702 | 3 | 0 | 3 |
| CA8 | IFT122 | 0.698787 | 3 | 0 | 3 |
| CA8 | CSH1 | 0.698554 | 3 | 0 | 3 |
| CA8 | SULT2A1 | 0.698183 | 3 | 0 | 3 |
| CA8 | CCKAR | 0.693061 | 4 | 0 | 4 |
| CA8 | NEUROD1 | 0.689591 | 4 | 0 | 4 |
| CA8 | GNG3 | 0.684584 | 4 | 0 | 3 |
| CA8 | CXCR1 | 0.679871 | 3 | 0 | 3 |
| CA8 | KCNMB2 | 0.675807 | 4 | 0 | 3 |
For details and further investigation, click here
