| Full name: activin A receptor like type 1 | Alias Symbol: HHT2|ALK1|HHT | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 94 | HGNC ID: HGNC:175 | Ensembl Gene: ENSG00000139567 | OMIM ID: 601284 |
| Drug and gene relationship at DGIdb | |||
Expression of ACVRL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACVRL1 | 94 | 226950_at | 0.2735 | 0.5737 | |
| GSE20347 | ACVRL1 | 94 | 210838_s_at | -0.0680 | 0.2920 | |
| GSE23400 | ACVRL1 | 94 | 210838_s_at | -0.2525 | 0.0000 | |
| GSE26886 | ACVRL1 | 94 | 226950_at | -0.1488 | 0.4442 | |
| GSE29001 | ACVRL1 | 94 | 210838_s_at | -0.1634 | 0.2768 | |
| GSE38129 | ACVRL1 | 94 | 210838_s_at | -0.5495 | 0.0001 | |
| GSE45670 | ACVRL1 | 94 | 226950_at | -0.4812 | 0.0469 | |
| GSE53622 | ACVRL1 | 94 | 46590 | -0.2238 | 0.1895 | |
| GSE53624 | ACVRL1 | 94 | 46590 | 0.2887 | 0.0222 | |
| GSE63941 | ACVRL1 | 94 | 210838_s_at | -0.3527 | 0.0888 | |
| GSE77861 | ACVRL1 | 94 | 226950_at | 0.0072 | 0.9650 | |
| GSE97050 | ACVRL1 | 94 | A_24_P945113 | 0.1538 | 0.6811 | |
| SRP007169 | ACVRL1 | 94 | RNAseq | 0.7005 | 0.1252 | |
| SRP008496 | ACVRL1 | 94 | RNAseq | 1.1984 | 0.0017 | |
| SRP064894 | ACVRL1 | 94 | RNAseq | 0.7509 | 0.0412 | |
| SRP133303 | ACVRL1 | 94 | RNAseq | -0.3112 | 0.0869 | |
| SRP159526 | ACVRL1 | 94 | RNAseq | -0.0613 | 0.8745 | |
| SRP193095 | ACVRL1 | 94 | RNAseq | 0.9278 | 0.0001 | |
| SRP219564 | ACVRL1 | 94 | RNAseq | -0.1609 | 0.7771 | |
| TCGA | ACVRL1 | 94 | RNAseq | -0.4529 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ACVRL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACVRL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACVRL1 | 94 | 8 | 2 | 20 | |
| GSE20123 | ACVRL1 | 94 | 8 | 1 | 21 | |
| GSE43470 | ACVRL1 | 94 | 4 | 0 | 39 | |
| GSE46452 | ACVRL1 | 94 | 7 | 1 | 51 | |
| GSE47630 | ACVRL1 | 94 | 10 | 2 | 28 | |
| GSE54993 | ACVRL1 | 94 | 0 | 5 | 65 | |
| GSE54994 | ACVRL1 | 94 | 3 | 2 | 48 | |
| GSE60625 | ACVRL1 | 94 | 0 | 0 | 11 | |
| GSE74703 | ACVRL1 | 94 | 3 | 0 | 33 | |
| GSE74704 | ACVRL1 | 94 | 5 | 1 | 14 | |
| TCGA | ACVRL1 | 94 | 13 | 11 | 72 |
Total number of gains: 61; Total number of losses: 25; Total Number of normals: 402.
Somatic mutations of ACVRL1:
Generating mutation plots.
Highly correlated genes for ACVRL1:
Showing top 20/762 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACVRL1 | SSH2 | 0.769422 | 3 | 0 | 3 |
| ACVRL1 | MRPL41 | 0.765197 | 3 | 0 | 3 |
| ACVRL1 | EMCN | 0.753544 | 4 | 0 | 4 |
| ACVRL1 | C19orf38 | 0.747594 | 3 | 0 | 3 |
| ACVRL1 | TIE1 | 0.743241 | 7 | 0 | 7 |
| ACVRL1 | VPS52 | 0.731889 | 3 | 0 | 3 |
| ACVRL1 | MED27 | 0.729396 | 3 | 0 | 3 |
| ACVRL1 | PSKH1 | 0.726373 | 4 | 0 | 3 |
| ACVRL1 | LMAN1 | 0.722171 | 4 | 0 | 3 |
| ACVRL1 | CD53 | 0.716234 | 3 | 0 | 3 |
| ACVRL1 | CLEC14A | 0.715027 | 7 | 0 | 7 |
| ACVRL1 | TGFBR2 | 0.712908 | 5 | 0 | 5 |
| ACVRL1 | IFI27L2 | 0.704964 | 3 | 0 | 3 |
| ACVRL1 | TSHR | 0.704368 | 3 | 0 | 3 |
| ACVRL1 | GDF10 | 0.703737 | 4 | 0 | 3 |
| ACVRL1 | IRS4 | 0.703509 | 3 | 0 | 3 |
| ACVRL1 | GIMAP6 | 0.696661 | 6 | 0 | 6 |
| ACVRL1 | KCND3 | 0.693078 | 5 | 0 | 4 |
| ACVRL1 | UBE2D4 | 0.691664 | 4 | 0 | 4 |
| ACVRL1 | KCNC4 | 0.691366 | 4 | 0 | 3 |
For details and further investigation, click here
