| Full name: semaphorin 3B | Alias Symbol: SemA|semaV|LUCA-1|sema5 | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 7869 | HGNC ID: HGNC:10724 | Ensembl Gene: ENSG00000012171 | OMIM ID: 601281 |
| Drug and gene relationship at DGIdb | |||
SEMA3B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of SEMA3B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEMA3B | 7869 | 203070_at | -0.1385 | 0.5851 | |
| GSE20347 | SEMA3B | 7869 | 203070_at | -0.2106 | 0.0252 | |
| GSE23400 | SEMA3B | 7869 | 203070_at | -0.1894 | 0.0000 | |
| GSE26886 | SEMA3B | 7869 | 203070_at | 0.2960 | 0.0464 | |
| GSE29001 | SEMA3B | 7869 | 203070_at | -0.2253 | 0.0827 | |
| GSE38129 | SEMA3B | 7869 | 203070_at | -0.1649 | 0.0123 | |
| GSE45670 | SEMA3B | 7869 | 203070_at | 0.0229 | 0.8915 | |
| GSE53622 | SEMA3B | 7869 | 72162 | -0.1964 | 0.0621 | |
| GSE53624 | SEMA3B | 7869 | 72162 | -0.5321 | 0.0000 | |
| GSE63941 | SEMA3B | 7869 | 203070_at | 0.2195 | 0.2303 | |
| GSE77861 | SEMA3B | 7869 | 203070_at | -0.2653 | 0.1813 | |
| GSE97050 | SEMA3B | 7869 | A_23_P132718 | -0.3469 | 0.3183 | |
| SRP007169 | SEMA3B | 7869 | RNAseq | 1.5525 | 0.0124 | |
| SRP064894 | SEMA3B | 7869 | RNAseq | 0.2721 | 0.4591 | |
| SRP133303 | SEMA3B | 7869 | RNAseq | -0.3538 | 0.2838 | |
| SRP193095 | SEMA3B | 7869 | RNAseq | -0.1082 | 0.8398 | |
| SRP219564 | SEMA3B | 7869 | RNAseq | -0.0450 | 0.9541 | |
| TCGA | SEMA3B | 7869 | RNAseq | -1.0518 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by SEMA3B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEMA3B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEMA3B | 7869 | 0 | 18 | 12 | |
| GSE20123 | SEMA3B | 7869 | 0 | 19 | 11 | |
| GSE43470 | SEMA3B | 7869 | 0 | 19 | 24 | |
| GSE46452 | SEMA3B | 7869 | 2 | 16 | 41 | |
| GSE47630 | SEMA3B | 7869 | 1 | 24 | 15 | |
| GSE54993 | SEMA3B | 7869 | 6 | 2 | 62 | |
| GSE54994 | SEMA3B | 7869 | 1 | 33 | 19 | |
| GSE60625 | SEMA3B | 7869 | 5 | 0 | 6 | |
| GSE74703 | SEMA3B | 7869 | 0 | 15 | 21 | |
| GSE74704 | SEMA3B | 7869 | 0 | 12 | 8 | |
| TCGA | SEMA3B | 7869 | 0 | 78 | 18 |
Total number of gains: 15; Total number of losses: 236; Total Number of normals: 237.
Somatic mutations of SEMA3B:
Generating mutation plots.
Highly correlated genes for SEMA3B:
Showing top 20/742 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEMA3B | PRAMEF12 | 0.785478 | 3 | 0 | 3 |
| SEMA3B | RASL10B | 0.760085 | 3 | 0 | 3 |
| SEMA3B | ARHGAP30 | 0.753124 | 4 | 0 | 4 |
| SEMA3B | USH1C | 0.750818 | 3 | 0 | 3 |
| SEMA3B | LENG1 | 0.74925 | 3 | 0 | 3 |
| SEMA3B | GPD1 | 0.737914 | 3 | 0 | 3 |
| SEMA3B | GJD4 | 0.736262 | 4 | 0 | 4 |
| SEMA3B | HRC | 0.7256 | 4 | 0 | 3 |
| SEMA3B | PTAFR | 0.714295 | 3 | 0 | 3 |
| SEMA3B | AIRE | 0.709208 | 6 | 0 | 5 |
| SEMA3B | PGC | 0.707073 | 4 | 0 | 3 |
| SEMA3B | CDH23 | 0.70281 | 4 | 0 | 3 |
| SEMA3B | IGFN1 | 0.701476 | 3 | 0 | 3 |
| SEMA3B | TRIM10 | 0.698859 | 5 | 0 | 4 |
| SEMA3B | IGSF21 | 0.698415 | 3 | 0 | 3 |
| SEMA3B | DNAH10 | 0.698246 | 3 | 0 | 3 |
| SEMA3B | CFP | 0.694615 | 3 | 0 | 3 |
| SEMA3B | ISYNA1 | 0.691828 | 5 | 0 | 4 |
| SEMA3B | DNAJB8 | 0.690282 | 3 | 0 | 3 |
| SEMA3B | ITGA2B | 0.689957 | 3 | 0 | 3 |
For details and further investigation, click here
