| Full name: sortilin related VPS10 domain containing receptor 2 | Alias Symbol: KIAA1329 | ||
| Type: protein-coding gene | Cytoband: 4p16.1 | ||
| Entrez ID: 57537 | HGNC ID: HGNC:16698 | Ensembl Gene: ENSG00000184985 | OMIM ID: 606284 |
| Drug and gene relationship at DGIdb | |||
Expression of SORCS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SORCS2 | 57537 | 228720_at | 0.1124 | 0.8466 | |
| GSE26886 | SORCS2 | 57537 | 228720_at | 0.1316 | 0.6833 | |
| GSE45670 | SORCS2 | 57537 | 228720_at | 0.0803 | 0.7489 | |
| GSE53622 | SORCS2 | 57537 | 23897 | 0.3255 | 0.0002 | |
| GSE53624 | SORCS2 | 57537 | 23897 | 0.1126 | 0.1917 | |
| GSE63941 | SORCS2 | 57537 | 228720_at | -0.0342 | 0.9676 | |
| GSE77861 | SORCS2 | 57537 | 228720_at | 0.0157 | 0.9434 | |
| GSE97050 | SORCS2 | 57537 | A_33_P3215834 | -0.0909 | 0.8416 | |
| SRP064894 | SORCS2 | 57537 | RNAseq | 0.8632 | 0.0258 | |
| SRP133303 | SORCS2 | 57537 | RNAseq | 0.9611 | 0.0395 | |
| SRP159526 | SORCS2 | 57537 | RNAseq | 0.7637 | 0.1550 | |
| SRP193095 | SORCS2 | 57537 | RNAseq | 0.5962 | 0.0210 | |
| SRP219564 | SORCS2 | 57537 | RNAseq | 0.5258 | 0.4741 | |
| TCGA | SORCS2 | 57537 | RNAseq | -0.1135 | 0.6082 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SORCS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SORCS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SORCS2 | 57537 | 0 | 18 | 12 | |
| GSE20123 | SORCS2 | 57537 | 0 | 18 | 12 | |
| GSE43470 | SORCS2 | 57537 | 0 | 17 | 26 | |
| GSE46452 | SORCS2 | 57537 | 1 | 36 | 22 | |
| GSE47630 | SORCS2 | 57537 | 1 | 19 | 20 | |
| GSE54993 | SORCS2 | 57537 | 10 | 0 | 60 | |
| GSE54994 | SORCS2 | 57537 | 3 | 12 | 38 | |
| GSE60625 | SORCS2 | 57537 | 0 | 0 | 11 | |
| GSE74703 | SORCS2 | 57537 | 0 | 13 | 23 | |
| GSE74704 | SORCS2 | 57537 | 0 | 10 | 10 | |
| TCGA | SORCS2 | 57537 | 7 | 49 | 40 |
Total number of gains: 22; Total number of losses: 192; Total Number of normals: 274.
Somatic mutations of SORCS2:
Generating mutation plots.
Highly correlated genes for SORCS2:
Showing top 20/98 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SORCS2 | SCN9A | 0.737807 | 3 | 0 | 3 |
| SORCS2 | TMPRSS5 | 0.73461 | 3 | 0 | 3 |
| SORCS2 | SEC14L4 | 0.733012 | 3 | 0 | 3 |
| SORCS2 | C19orf81 | 0.718776 | 3 | 0 | 3 |
| SORCS2 | ESPNL | 0.708612 | 4 | 0 | 3 |
| SORCS2 | CELF4 | 0.706821 | 3 | 0 | 3 |
| SORCS2 | ISYNA1 | 0.695814 | 4 | 0 | 4 |
| SORCS2 | DCDC1 | 0.683714 | 3 | 0 | 3 |
| SORCS2 | ITPKA | 0.680258 | 3 | 0 | 3 |
| SORCS2 | ADRA2C | 0.67373 | 4 | 0 | 3 |
| SORCS2 | OSBPL5 | 0.671736 | 3 | 0 | 3 |
| SORCS2 | SHC3 | 0.671262 | 3 | 0 | 3 |
| SORCS2 | PDE6C | 0.669386 | 4 | 0 | 4 |
| SORCS2 | TUT1 | 0.668424 | 3 | 0 | 3 |
| SORCS2 | IER5L | 0.664079 | 3 | 0 | 3 |
| SORCS2 | AVPR1B | 0.661615 | 3 | 0 | 3 |
| SORCS2 | DMGDH | 0.656196 | 3 | 0 | 3 |
| SORCS2 | PABPN1L | 0.648942 | 3 | 0 | 3 |
| SORCS2 | ASTN2 | 0.64878 | 3 | 0 | 3 |
| SORCS2 | CEND1 | 0.647163 | 4 | 0 | 3 |
For details and further investigation, click here
