| Full name: neurotrophic receptor tyrosine kinase 1 | Alias Symbol: TRK|TRKA|MTC | ||
| Type: protein-coding gene | Cytoband: 1q23.1 | ||
| Entrez ID: 4914 | HGNC ID: HGNC:8031 | Ensembl Gene: ENSG00000198400 | OMIM ID: 191315 |
| Drug and gene relationship at DGIdb | |||
NTRK1 involved pathways:
Expression of NTRK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NTRK1 | 4914 | 208605_s_at | 0.0420 | 0.8657 | |
| GSE20347 | NTRK1 | 4914 | 208605_s_at | -0.1208 | 0.0195 | |
| GSE23400 | NTRK1 | 4914 | 208605_s_at | -0.0975 | 0.0000 | |
| GSE26886 | NTRK1 | 4914 | 208605_s_at | 0.2239 | 0.0730 | |
| GSE29001 | NTRK1 | 4914 | 208605_s_at | -0.0239 | 0.8665 | |
| GSE38129 | NTRK1 | 4914 | 208605_s_at | -0.0849 | 0.1282 | |
| GSE45670 | NTRK1 | 4914 | 208605_s_at | -0.0101 | 0.9391 | |
| GSE53622 | NTRK1 | 4914 | 98724 | -0.0648 | 0.4155 | |
| GSE53624 | NTRK1 | 4914 | 98724 | 0.0050 | 0.9406 | |
| GSE63941 | NTRK1 | 4914 | 208605_s_at | 0.0665 | 0.6658 | |
| GSE77861 | NTRK1 | 4914 | 208605_s_at | -0.1692 | 0.1676 | |
| GSE97050 | NTRK1 | 4914 | A_24_P265506 | 0.1120 | 0.7168 | |
| SRP219564 | NTRK1 | 4914 | RNAseq | 1.3324 | 0.0359 | |
| TCGA | NTRK1 | 4914 | RNAseq | -0.5890 | 0.1730 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by NTRK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NTRK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NTRK1 | 4914 | 11 | 0 | 19 | |
| GSE20123 | NTRK1 | 4914 | 11 | 0 | 19 | |
| GSE43470 | NTRK1 | 4914 | 7 | 2 | 34 | |
| GSE46452 | NTRK1 | 4914 | 2 | 1 | 56 | |
| GSE47630 | NTRK1 | 4914 | 14 | 0 | 26 | |
| GSE54993 | NTRK1 | 4914 | 0 | 5 | 65 | |
| GSE54994 | NTRK1 | 4914 | 16 | 0 | 37 | |
| GSE60625 | NTRK1 | 4914 | 0 | 0 | 11 | |
| GSE74703 | NTRK1 | 4914 | 7 | 2 | 27 | |
| GSE74704 | NTRK1 | 4914 | 6 | 0 | 14 | |
| TCGA | NTRK1 | 4914 | 38 | 2 | 56 |
Total number of gains: 112; Total number of losses: 12; Total Number of normals: 364.
Somatic mutations of NTRK1:
Generating mutation plots.
Highly correlated genes for NTRK1:
Showing top 20/312 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NTRK1 | C7orf61 | 0.773192 | 3 | 0 | 3 |
| NTRK1 | LELP1 | 0.76228 | 3 | 0 | 3 |
| NTRK1 | FAM71A | 0.7256 | 3 | 0 | 3 |
| NTRK1 | DDC | 0.71876 | 3 | 0 | 3 |
| NTRK1 | TMEM52 | 0.715809 | 4 | 0 | 3 |
| NTRK1 | ISYNA1 | 0.713506 | 4 | 0 | 3 |
| NTRK1 | TUBGCP6 | 0.706312 | 3 | 0 | 3 |
| NTRK1 | COX4I2 | 0.699876 | 3 | 0 | 3 |
| NTRK1 | ZFPM1 | 0.699335 | 3 | 0 | 3 |
| NTRK1 | AVPR2 | 0.692959 | 4 | 0 | 3 |
| NTRK1 | SLC5A5 | 0.692048 | 4 | 0 | 3 |
| NTRK1 | TMEM221 | 0.691281 | 3 | 0 | 3 |
| NTRK1 | PTPRCAP | 0.688779 | 4 | 0 | 4 |
| NTRK1 | PTGIR | 0.688194 | 3 | 0 | 3 |
| NTRK1 | GPR26 | 0.667395 | 3 | 0 | 3 |
| NTRK1 | CNTD2 | 0.666481 | 4 | 0 | 3 |
| NTRK1 | CYP2D6 | 0.665629 | 4 | 0 | 4 |
| NTRK1 | KIF6 | 0.66434 | 3 | 0 | 3 |
| NTRK1 | SLC2A11 | 0.661713 | 4 | 0 | 3 |
| NTRK1 | DNAJB8 | 0.661337 | 4 | 0 | 4 |
For details and further investigation, click here
