| Full name: isovaleryl-CoA dehydrogenase | Alias Symbol: ACAD2 | ||
| Type: protein-coding gene | Cytoband: 15q15.1 | ||
| Entrez ID: 3712 | HGNC ID: HGNC:6186 | Ensembl Gene: ENSG00000128928 | OMIM ID: 607036 |
| Drug and gene relationship at DGIdb | |||
Expression of IVD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IVD | 3712 | 225311_at | -0.2538 | 0.6306 | |
| GSE20347 | IVD | 3712 | 216958_s_at | 0.5171 | 0.0029 | |
| GSE23400 | IVD | 3712 | 216958_s_at | 0.2266 | 0.0012 | |
| GSE26886 | IVD | 3712 | 225311_at | 0.5859 | 0.0825 | |
| GSE29001 | IVD | 3712 | 203682_s_at | -0.2609 | 0.1125 | |
| GSE38129 | IVD | 3712 | 216958_s_at | 0.4445 | 0.0010 | |
| GSE45670 | IVD | 3712 | 225311_at | -0.2575 | 0.0830 | |
| GSE53622 | IVD | 3712 | 23632 | 0.0555 | 0.5356 | |
| GSE53624 | IVD | 3712 | 23632 | 0.0887 | 0.2272 | |
| GSE63941 | IVD | 3712 | 225311_at | -0.6148 | 0.2058 | |
| GSE77861 | IVD | 3712 | 225311_at | -0.0254 | 0.8948 | |
| GSE97050 | IVD | 3712 | A_33_P3269718 | -0.0046 | 0.9830 | |
| SRP007169 | IVD | 3712 | RNAseq | 0.1952 | 0.5923 | |
| SRP008496 | IVD | 3712 | RNAseq | 0.0416 | 0.9020 | |
| SRP064894 | IVD | 3712 | RNAseq | -0.0352 | 0.8749 | |
| SRP133303 | IVD | 3712 | RNAseq | -0.0734 | 0.7494 | |
| SRP159526 | IVD | 3712 | RNAseq | 0.3693 | 0.0596 | |
| SRP193095 | IVD | 3712 | RNAseq | 0.0842 | 0.6426 | |
| SRP219564 | IVD | 3712 | RNAseq | -0.1823 | 0.7505 | |
| TCGA | IVD | 3712 | RNAseq | -0.4004 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IVD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IVD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IVD | 3712 | 4 | 5 | 21 | |
| GSE20123 | IVD | 3712 | 4 | 5 | 21 | |
| GSE43470 | IVD | 3712 | 4 | 6 | 33 | |
| GSE46452 | IVD | 3712 | 3 | 7 | 49 | |
| GSE47630 | IVD | 3712 | 8 | 11 | 21 | |
| GSE54993 | IVD | 3712 | 4 | 6 | 60 | |
| GSE54994 | IVD | 3712 | 5 | 7 | 41 | |
| GSE60625 | IVD | 3712 | 4 | 0 | 7 | |
| GSE74703 | IVD | 3712 | 4 | 5 | 27 | |
| GSE74704 | IVD | 3712 | 3 | 3 | 14 | |
| TCGA | IVD | 3712 | 11 | 18 | 67 |
Total number of gains: 54; Total number of losses: 73; Total Number of normals: 361.
Somatic mutations of IVD:
Generating mutation plots.
Highly correlated genes for IVD:
Showing top 20/42 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IVD | NKX2-8 | 0.758868 | 3 | 0 | 3 |
| IVD | FAM24B | 0.706698 | 3 | 0 | 3 |
| IVD | NXPH3 | 0.696958 | 3 | 0 | 3 |
| IVD | PRAME | 0.685369 | 3 | 0 | 3 |
| IVD | VWA5B2 | 0.683285 | 3 | 0 | 3 |
| IVD | BAALC | 0.682379 | 3 | 0 | 3 |
| IVD | THAP3 | 0.678958 | 3 | 0 | 3 |
| IVD | ZNF500 | 0.659207 | 4 | 0 | 3 |
| IVD | CLDN3 | 0.647885 | 4 | 0 | 4 |
| IVD | C16orf89 | 0.646047 | 4 | 0 | 3 |
| IVD | ACTR1B | 0.640451 | 4 | 0 | 3 |
| IVD | SCRN2 | 0.638019 | 4 | 0 | 3 |
| IVD | PTCH1 | 0.624447 | 3 | 0 | 3 |
| IVD | TRAPPC6A | 0.612093 | 5 | 0 | 4 |
| IVD | BAHCC1 | 0.609461 | 4 | 0 | 3 |
| IVD | TCEANC | 0.606384 | 3 | 0 | 3 |
| IVD | PIWIL4 | 0.605452 | 3 | 0 | 3 |
| IVD | RPIA | 0.604082 | 4 | 0 | 3 |
| IVD | BCAP31 | 0.60327 | 4 | 0 | 3 |
| IVD | GTF2IRD2B | 0.601373 | 4 | 0 | 3 |
For details and further investigation, click here
