| Full name: claudin 3 | Alias Symbol: RVP1|CPE-R2|HRVP1 | ||
| Type: protein-coding gene | Cytoband: 7q11.23 | ||
| Entrez ID: 1365 | HGNC ID: HGNC:2045 | Ensembl Gene: ENSG00000165215 | OMIM ID: 602910 |
| Drug and gene relationship at DGIdb | |||
CLDN3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of CLDN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLDN3 | 1365 | 203954_x_at | -0.1242 | 0.8516 | |
| GSE20347 | CLDN3 | 1365 | 203954_x_at | 0.1637 | 0.2747 | |
| GSE23400 | CLDN3 | 1365 | 203954_x_at | -0.0279 | 0.4811 | |
| GSE26886 | CLDN3 | 1365 | 203954_x_at | 0.5145 | 0.0207 | |
| GSE29001 | CLDN3 | 1365 | 203954_x_at | 0.0560 | 0.7476 | |
| GSE38129 | CLDN3 | 1365 | 203954_x_at | 0.2564 | 0.1028 | |
| GSE45670 | CLDN3 | 1365 | 203954_x_at | 0.0135 | 0.9146 | |
| GSE53622 | CLDN3 | 1365 | 47650 | 0.8840 | 0.0001 | |
| GSE53624 | CLDN3 | 1365 | 107205 | 0.2388 | 0.1291 | |
| GSE63941 | CLDN3 | 1365 | 203954_x_at | 1.1948 | 0.0945 | |
| GSE77861 | CLDN3 | 1365 | 203954_x_at | 0.0860 | 0.6195 | |
| GSE97050 | CLDN3 | 1365 | A_33_P3285565 | -0.3698 | 0.3249 | |
| SRP007169 | CLDN3 | 1365 | RNAseq | 4.6894 | 0.0009 | |
| SRP133303 | CLDN3 | 1365 | RNAseq | 0.4898 | 0.5141 | |
| TCGA | CLDN3 | 1365 | RNAseq | 0.5072 | 0.1796 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CLDN3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLDN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLDN3 | 1365 | 14 | 1 | 15 | |
| GSE20123 | CLDN3 | 1365 | 14 | 1 | 15 | |
| GSE43470 | CLDN3 | 1365 | 3 | 2 | 38 | |
| GSE46452 | CLDN3 | 1365 | 12 | 0 | 47 | |
| GSE47630 | CLDN3 | 1365 | 7 | 2 | 31 | |
| GSE54993 | CLDN3 | 1365 | 2 | 7 | 61 | |
| GSE54994 | CLDN3 | 1365 | 14 | 3 | 36 | |
| GSE60625 | CLDN3 | 1365 | 0 | 0 | 11 | |
| GSE74703 | CLDN3 | 1365 | 3 | 1 | 32 | |
| GSE74704 | CLDN3 | 1365 | 8 | 1 | 11 | |
| TCGA | CLDN3 | 1365 | 45 | 7 | 44 |
Total number of gains: 122; Total number of losses: 25; Total Number of normals: 341.
Somatic mutations of CLDN3:
Generating mutation plots.
Highly correlated genes for CLDN3:
Showing top 20/110 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLDN3 | WNK2 | 0.764709 | 3 | 0 | 3 |
| CLDN3 | TRAM1L1 | 0.712967 | 3 | 0 | 3 |
| CLDN3 | CASC1 | 0.691907 | 5 | 0 | 5 |
| CLDN3 | NRK | 0.670694 | 3 | 0 | 3 |
| CLDN3 | TKTL1 | 0.668897 | 3 | 0 | 3 |
| CLDN3 | ARHGEF26 | 0.661513 | 3 | 0 | 3 |
| CLDN3 | DACH1 | 0.660699 | 3 | 0 | 3 |
| CLDN3 | RASSF8 | 0.65379 | 4 | 0 | 4 |
| CLDN3 | NRXN1 | 0.653187 | 3 | 0 | 3 |
| CLDN3 | ITGA9 | 0.651515 | 3 | 0 | 3 |
| CLDN3 | IVD | 0.647885 | 4 | 0 | 4 |
| CLDN3 | ZNF446 | 0.639154 | 4 | 0 | 3 |
| CLDN3 | NPY | 0.635723 | 3 | 0 | 3 |
| CLDN3 | TRAM2-AS1 | 0.634916 | 3 | 0 | 3 |
| CLDN3 | KAT8 | 0.622784 | 5 | 0 | 4 |
| CLDN3 | AGPAT1 | 0.622734 | 3 | 0 | 3 |
| CLDN3 | SIGIRR | 0.622235 | 4 | 0 | 4 |
| CLDN3 | NGFR | 0.619815 | 6 | 0 | 5 |
| CLDN3 | GPC3 | 0.619382 | 4 | 0 | 3 |
| CLDN3 | LINC00667 | 0.618799 | 3 | 0 | 3 |
For details and further investigation, click here
