| Full name: NK2 homeobox 8 | Alias Symbol: NKX2.8|Nkx2-9 | ||
| Type: protein-coding gene | Cytoband: 14q13.3 | ||
| Entrez ID: 26257 | HGNC ID: HGNC:16364 | Ensembl Gene: ENSG00000136327 | OMIM ID: 603245 |
| Drug and gene relationship at DGIdb | |||
Expression of NKX2-8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NKX2-8 | 26257 | 207451_at | -0.0601 | 0.8964 | |
| GSE20347 | NKX2-8 | 26257 | 207451_at | -0.2099 | 0.0487 | |
| GSE23400 | NKX2-8 | 26257 | 207451_at | -0.1356 | 0.0000 | |
| GSE26886 | NKX2-8 | 26257 | 207451_at | 0.3725 | 0.0080 | |
| GSE29001 | NKX2-8 | 26257 | 207451_at | -0.1773 | 0.2332 | |
| GSE38129 | NKX2-8 | 26257 | 207451_at | -0.1127 | 0.2915 | |
| GSE45670 | NKX2-8 | 26257 | 207451_at | 0.0263 | 0.8541 | |
| GSE63941 | NKX2-8 | 26257 | 207451_at | 0.7940 | 0.0653 | |
| GSE77861 | NKX2-8 | 26257 | 207451_at | -0.1687 | 0.3272 | |
| GSE97050 | NKX2-8 | 26257 | A_33_P3381490 | -0.0311 | 0.8933 | |
| SRP133303 | NKX2-8 | 26257 | RNAseq | 1.3652 | 0.0300 | |
| SRP159526 | NKX2-8 | 26257 | RNAseq | 0.2939 | 0.6540 | |
| TCGA | NKX2-8 | 26257 | RNAseq | 2.2162 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by NKX2-8 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of NKX2-8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NKX2-8 | 26257 | 11 | 4 | 15 | |
| GSE20123 | NKX2-8 | 26257 | 12 | 4 | 14 | |
| GSE43470 | NKX2-8 | 26257 | 8 | 2 | 33 | |
| GSE46452 | NKX2-8 | 26257 | 18 | 2 | 39 | |
| GSE47630 | NKX2-8 | 26257 | 11 | 10 | 19 | |
| GSE54993 | NKX2-8 | 26257 | 3 | 11 | 56 | |
| GSE54994 | NKX2-8 | 26257 | 19 | 5 | 29 | |
| GSE60625 | NKX2-8 | 26257 | 0 | 2 | 9 | |
| GSE74703 | NKX2-8 | 26257 | 7 | 2 | 27 | |
| GSE74704 | NKX2-8 | 26257 | 6 | 3 | 11 |
Total number of gains: 95; Total number of losses: 45; Total Number of normals: 252.
Somatic mutations of NKX2-8:
Generating mutation plots.
Highly correlated genes for NKX2-8:
Showing top 20/401 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NKX2-8 | LENG1 | 0.762574 | 3 | 0 | 3 |
| NKX2-8 | IVD | 0.758868 | 3 | 0 | 3 |
| NKX2-8 | MGAT5B | 0.755464 | 4 | 0 | 4 |
| NKX2-8 | IGSF9B | 0.755238 | 3 | 0 | 3 |
| NKX2-8 | NUDT16L1 | 0.753641 | 3 | 0 | 3 |
| NKX2-8 | GTF2IRD2 | 0.753202 | 3 | 0 | 3 |
| NKX2-8 | ADM2 | 0.750268 | 4 | 0 | 4 |
| NKX2-8 | RAD52 | 0.739056 | 4 | 0 | 4 |
| NKX2-8 | NTNG2 | 0.734571 | 3 | 0 | 3 |
| NKX2-8 | LRRC46 | 0.727552 | 4 | 0 | 4 |
| NKX2-8 | VCX2 | 0.714526 | 4 | 0 | 4 |
| NKX2-8 | NCR3 | 0.706843 | 4 | 0 | 4 |
| NKX2-8 | C9orf131 | 0.705815 | 3 | 0 | 3 |
| NKX2-8 | WDR90 | 0.702132 | 4 | 0 | 4 |
| NKX2-8 | TRPV3 | 0.699109 | 3 | 0 | 3 |
| NKX2-8 | PCP2 | 0.698578 | 4 | 0 | 3 |
| NKX2-8 | RASL10B | 0.693264 | 4 | 0 | 3 |
| NKX2-8 | REG3A | 0.687533 | 5 | 0 | 4 |
| NKX2-8 | FOXA3 | 0.687192 | 4 | 0 | 3 |
| NKX2-8 | DNAJB8 | 0.684941 | 4 | 0 | 3 |
For details and further investigation, click here
