| Full name: karyopherin subunit alpha 1 | Alias Symbol: SRP1|RCH2|NPI-1|IPOA5 | ||
| Type: protein-coding gene | Cytoband: 3q21.1 | ||
| Entrez ID: 3836 | HGNC ID: HGNC:6394 | Ensembl Gene: ENSG00000114030 | OMIM ID: 600686 |
| Drug and gene relationship at DGIdb | |||
Expression of KPNA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KPNA1 | 3836 | 202059_s_at | 0.8660 | 0.1225 | |
| GSE20347 | KPNA1 | 3836 | 202059_s_at | 0.3960 | 0.0224 | |
| GSE23400 | KPNA1 | 3836 | 202059_s_at | 0.5091 | 0.0000 | |
| GSE26886 | KPNA1 | 3836 | 202059_s_at | 1.4162 | 0.0000 | |
| GSE29001 | KPNA1 | 3836 | 202059_s_at | 0.0857 | 0.8511 | |
| GSE38129 | KPNA1 | 3836 | 202059_s_at | 0.5941 | 0.0001 | |
| GSE45670 | KPNA1 | 3836 | 202059_s_at | 0.6077 | 0.0006 | |
| GSE53622 | KPNA1 | 3836 | 90995 | 0.2001 | 0.0081 | |
| GSE53624 | KPNA1 | 3836 | 90995 | 0.2932 | 0.0000 | |
| GSE63941 | KPNA1 | 3836 | 202056_at | -0.4823 | 0.3419 | |
| GSE77861 | KPNA1 | 3836 | 202055_at | 0.3097 | 0.4088 | |
| GSE97050 | KPNA1 | 3836 | A_33_P3214879 | -0.2256 | 0.3835 | |
| SRP007169 | KPNA1 | 3836 | RNAseq | 0.4900 | 0.1207 | |
| SRP008496 | KPNA1 | 3836 | RNAseq | 0.4793 | 0.0580 | |
| SRP064894 | KPNA1 | 3836 | RNAseq | 0.2960 | 0.0906 | |
| SRP133303 | KPNA1 | 3836 | RNAseq | 0.6307 | 0.0004 | |
| SRP159526 | KPNA1 | 3836 | RNAseq | 0.3651 | 0.2131 | |
| SRP193095 | KPNA1 | 3836 | RNAseq | 0.5239 | 0.0000 | |
| SRP219564 | KPNA1 | 3836 | RNAseq | 0.0824 | 0.6855 | |
| TCGA | KPNA1 | 3836 | RNAseq | 0.0983 | 0.0396 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by KPNA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KPNA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KPNA1 | 3836 | 18 | 0 | 12 | |
| GSE20123 | KPNA1 | 3836 | 18 | 0 | 12 | |
| GSE43470 | KPNA1 | 3836 | 20 | 0 | 23 | |
| GSE46452 | KPNA1 | 3836 | 14 | 5 | 40 | |
| GSE47630 | KPNA1 | 3836 | 16 | 5 | 19 | |
| GSE54993 | KPNA1 | 3836 | 2 | 6 | 62 | |
| GSE54994 | KPNA1 | 3836 | 30 | 4 | 19 | |
| GSE60625 | KPNA1 | 3836 | 0 | 6 | 5 | |
| GSE74703 | KPNA1 | 3836 | 16 | 0 | 20 | |
| GSE74704 | KPNA1 | 3836 | 13 | 0 | 7 | |
| TCGA | KPNA1 | 3836 | 54 | 6 | 36 |
Total number of gains: 201; Total number of losses: 32; Total Number of normals: 255.
Somatic mutations of KPNA1:
Generating mutation plots.
Highly correlated genes for KPNA1:
Showing top 20/842 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KPNA1 | KDM6B | 0.820148 | 3 | 0 | 3 |
| KPNA1 | GSK3A | 0.795653 | 3 | 0 | 3 |
| KPNA1 | SNAPC2 | 0.793864 | 3 | 0 | 3 |
| KPNA1 | ZMYND19 | 0.792114 | 3 | 0 | 3 |
| KPNA1 | TMEM63B | 0.789721 | 3 | 0 | 3 |
| KPNA1 | WDR4 | 0.755993 | 4 | 0 | 4 |
| KPNA1 | SLC25A29 | 0.751142 | 3 | 0 | 3 |
| KPNA1 | MZT2B | 0.74985 | 3 | 0 | 3 |
| KPNA1 | POLR1B | 0.747577 | 4 | 0 | 4 |
| KPNA1 | SSBP4 | 0.744729 | 3 | 0 | 3 |
| KPNA1 | PPP1R16A | 0.73591 | 3 | 0 | 3 |
| KPNA1 | SIPA1L2 | 0.735198 | 3 | 0 | 3 |
| KPNA1 | XXYLT1 | 0.733565 | 4 | 0 | 4 |
| KPNA1 | NRARP | 0.732099 | 3 | 0 | 3 |
| KPNA1 | JUN | 0.731502 | 3 | 0 | 3 |
| KPNA1 | MRPL55 | 0.731339 | 4 | 0 | 4 |
| KPNA1 | YDJC | 0.728763 | 3 | 0 | 3 |
| KPNA1 | GOLIM4 | 0.725053 | 4 | 0 | 4 |
| KPNA1 | DGKH | 0.724883 | 3 | 0 | 3 |
| KPNA1 | FANCL | 0.724044 | 4 | 0 | 3 |
For details and further investigation, click here
