| Full name: FA complementation group L | Alias Symbol: FLJ10335|FAAP43|Pog | ||
| Type: protein-coding gene | Cytoband: 2p16.1 | ||
| Entrez ID: 55120 | HGNC ID: HGNC:20748 | Ensembl Gene: ENSG00000115392 | OMIM ID: 608111 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
FANCL involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03460 | Fanconi anemia pathway |
Expression of FANCL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FANCL | 55120 | 218397_at | 0.6485 | 0.1564 | |
| GSE20347 | FANCL | 55120 | 218397_at | 0.8284 | 0.0001 | |
| GSE23400 | FANCL | 55120 | 218397_at | 0.8055 | 0.0000 | |
| GSE26886 | FANCL | 55120 | 218397_at | 0.8634 | 0.0041 | |
| GSE29001 | FANCL | 55120 | 218397_at | 0.6738 | 0.0368 | |
| GSE38129 | FANCL | 55120 | 218397_at | 0.9102 | 0.0000 | |
| GSE45670 | FANCL | 55120 | 218397_at | 0.5387 | 0.0026 | |
| GSE53622 | FANCL | 55120 | 109565 | 0.2591 | 0.0006 | |
| GSE53624 | FANCL | 55120 | 109565 | 0.3605 | 0.0000 | |
| GSE63941 | FANCL | 55120 | 218397_at | 1.4894 | 0.0016 | |
| GSE77861 | FANCL | 55120 | 218397_at | 0.9422 | 0.0068 | |
| GSE97050 | FANCL | 55120 | A_23_P131383 | 0.1017 | 0.7914 | |
| SRP007169 | FANCL | 55120 | RNAseq | 0.5100 | 0.2178 | |
| SRP008496 | FANCL | 55120 | RNAseq | 0.5860 | 0.0348 | |
| SRP064894 | FANCL | 55120 | RNAseq | 0.6396 | 0.0037 | |
| SRP133303 | FANCL | 55120 | RNAseq | 0.3911 | 0.0894 | |
| SRP159526 | FANCL | 55120 | RNAseq | 0.6259 | 0.1296 | |
| SRP193095 | FANCL | 55120 | RNAseq | 0.1480 | 0.1762 | |
| SRP219564 | FANCL | 55120 | RNAseq | 0.5809 | 0.1462 | |
| TCGA | FANCL | 55120 | RNAseq | 0.3427 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by FANCL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FANCL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FANCL | 55120 | 7 | 1 | 22 | |
| GSE20123 | FANCL | 55120 | 7 | 1 | 22 | |
| GSE43470 | FANCL | 55120 | 6 | 0 | 37 | |
| GSE46452 | FANCL | 55120 | 2 | 3 | 54 | |
| GSE47630 | FANCL | 55120 | 8 | 0 | 32 | |
| GSE54993 | FANCL | 55120 | 0 | 6 | 64 | |
| GSE54994 | FANCL | 55120 | 12 | 0 | 41 | |
| GSE60625 | FANCL | 55120 | 0 | 3 | 8 | |
| GSE74703 | FANCL | 55120 | 6 | 0 | 30 | |
| GSE74704 | FANCL | 55120 | 7 | 1 | 12 | |
| TCGA | FANCL | 55120 | 35 | 3 | 58 |
Total number of gains: 90; Total number of losses: 18; Total Number of normals: 380.
Somatic mutations of FANCL:
Generating mutation plots.
Highly correlated genes for FANCL:
Showing top 20/1566 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FANCL | RICTOR | 0.857847 | 4 | 0 | 4 |
| FANCL | SAMD1 | 0.837527 | 3 | 0 | 3 |
| FANCL | LYAR | 0.834657 | 3 | 0 | 3 |
| FANCL | PPP1R16A | 0.814428 | 3 | 0 | 3 |
| FANCL | CRTC2 | 0.806678 | 3 | 0 | 3 |
| FANCL | B3GALT6 | 0.790778 | 3 | 0 | 3 |
| FANCL | IAH1 | 0.790178 | 4 | 0 | 4 |
| FANCL | ZFHX3 | 0.776575 | 3 | 0 | 3 |
| FANCL | RILPL2 | 0.773094 | 3 | 0 | 3 |
| FANCL | U2SURP | 0.771932 | 10 | 0 | 10 |
| FANCL | ZNF830 | 0.771579 | 3 | 0 | 3 |
| FANCL | SLC37A3 | 0.770574 | 3 | 0 | 3 |
| FANCL | ANAPC4 | 0.769265 | 3 | 0 | 3 |
| FANCL | SEMA3C | 0.767069 | 3 | 0 | 3 |
| FANCL | PHF3 | 0.756199 | 4 | 0 | 4 |
| FANCL | LPCAT2 | 0.753294 | 3 | 0 | 3 |
| FANCL | DCAF16 | 0.743219 | 5 | 0 | 4 |
| FANCL | ANKRD40 | 0.740505 | 4 | 0 | 4 |
| FANCL | PIEZO1 | 0.735523 | 3 | 0 | 3 |
| FANCL | ARHGAP39 | 0.730542 | 3 | 0 | 3 |
For details and further investigation, click here
