| Full name: WD repeat domain 4 | Alias Symbol: TRM82|TRMT82 | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 10785 | HGNC ID: HGNC:12756 | Ensembl Gene: ENSG00000160193 | OMIM ID: 605924 |
| Drug and gene relationship at DGIdb | |||
Expression of WDR4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WDR4 | 10785 | 241937_s_at | 1.2938 | 0.0523 | |
| GSE20347 | WDR4 | 10785 | 221632_s_at | 0.1348 | 0.1186 | |
| GSE23400 | WDR4 | 10785 | 221632_s_at | -0.0069 | 0.8706 | |
| GSE26886 | WDR4 | 10785 | 241937_s_at | 0.1370 | 0.6477 | |
| GSE29001 | WDR4 | 10785 | 221632_s_at | 0.3027 | 0.0747 | |
| GSE38129 | WDR4 | 10785 | 221632_s_at | 0.1951 | 0.0203 | |
| GSE45670 | WDR4 | 10785 | 241937_s_at | 0.8977 | 0.0000 | |
| GSE53622 | WDR4 | 10785 | 118209 | 0.4976 | 0.0083 | |
| GSE53624 | WDR4 | 10785 | 118209 | 0.7990 | 0.0000 | |
| GSE63941 | WDR4 | 10785 | 241937_s_at | 0.3388 | 0.6977 | |
| GSE77861 | WDR4 | 10785 | 221632_s_at | 0.0080 | 0.9601 | |
| GSE97050 | WDR4 | 10785 | A_23_P143535 | 0.1341 | 0.4761 | |
| SRP007169 | WDR4 | 10785 | RNAseq | 1.1192 | 0.0523 | |
| SRP064894 | WDR4 | 10785 | RNAseq | 1.0033 | 0.0004 | |
| SRP133303 | WDR4 | 10785 | RNAseq | 0.2751 | 0.1984 | |
| SRP159526 | WDR4 | 10785 | RNAseq | 0.6648 | 0.1279 | |
| SRP193095 | WDR4 | 10785 | RNAseq | 0.4951 | 0.0003 | |
| SRP219564 | WDR4 | 10785 | RNAseq | 0.4731 | 0.3490 | |
| TCGA | WDR4 | 10785 | RNAseq | 0.2971 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by WDR4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WDR4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WDR4 | 10785 | 2 | 8 | 20 | |
| GSE20123 | WDR4 | 10785 | 2 | 8 | 20 | |
| GSE43470 | WDR4 | 10785 | 0 | 13 | 30 | |
| GSE46452 | WDR4 | 10785 | 1 | 21 | 37 | |
| GSE47630 | WDR4 | 10785 | 6 | 17 | 17 | |
| GSE54993 | WDR4 | 10785 | 8 | 1 | 61 | |
| GSE54994 | WDR4 | 10785 | 4 | 8 | 41 | |
| GSE60625 | WDR4 | 10785 | 0 | 0 | 11 | |
| GSE74703 | WDR4 | 10785 | 0 | 10 | 26 | |
| GSE74704 | WDR4 | 10785 | 1 | 4 | 15 | |
| TCGA | WDR4 | 10785 | 7 | 40 | 49 |
Total number of gains: 31; Total number of losses: 130; Total Number of normals: 327.
Somatic mutations of WDR4:
Generating mutation plots.
Highly correlated genes for WDR4:
Showing top 20/1101 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WDR4 | ATRIP | 0.812149 | 3 | 0 | 3 |
| WDR4 | HMGB3 | 0.807864 | 3 | 0 | 3 |
| WDR4 | RACGAP1 | 0.788608 | 3 | 0 | 3 |
| WDR4 | MAP3K2 | 0.784434 | 3 | 0 | 3 |
| WDR4 | KTI12 | 0.783589 | 3 | 0 | 3 |
| WDR4 | SLC25A44 | 0.782647 | 4 | 0 | 4 |
| WDR4 | KRTCAP2 | 0.777766 | 3 | 0 | 3 |
| WDR4 | LTV1 | 0.777567 | 3 | 0 | 3 |
| WDR4 | RBBP5 | 0.77324 | 3 | 0 | 3 |
| WDR4 | ALKBH6 | 0.766997 | 3 | 0 | 3 |
| WDR4 | MSN | 0.759534 | 3 | 0 | 3 |
| WDR4 | CDCA2 | 0.758829 | 3 | 0 | 3 |
| WDR4 | KHSRP | 0.758687 | 4 | 0 | 4 |
| WDR4 | RNF187 | 0.756992 | 3 | 0 | 3 |
| WDR4 | KPNA1 | 0.755993 | 4 | 0 | 4 |
| WDR4 | MRPL14 | 0.755736 | 5 | 0 | 5 |
| WDR4 | RSRC1 | 0.755246 | 4 | 0 | 3 |
| WDR4 | PPP1R9B | 0.754213 | 4 | 0 | 4 |
| WDR4 | MAGOHB | 0.747636 | 3 | 0 | 3 |
| WDR4 | SLC39A3 | 0.746093 | 3 | 0 | 3 |
For details and further investigation, click here
