| Full name: glycogen synthase kinase 3 alpha | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 2931 | HGNC ID: HGNC:4616 | Ensembl Gene: ENSG00000105723 | OMIM ID: 606784 |
| Drug and gene relationship at DGIdb | |||
GSK3A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway | |
| hsa04728 | Dopaminergic synapse | |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) |
Expression of GSK3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GSK3A | 2931 | 632_at | 0.1493 | 0.5365 | |
| GSE20347 | GSK3A | 2931 | 632_at | -0.0562 | 0.3816 | |
| GSE23400 | GSK3A | 2931 | 632_at | -0.0581 | 0.2391 | |
| GSE26886 | GSK3A | 2931 | 202210_x_at | 0.4528 | 0.0023 | |
| GSE29001 | GSK3A | 2931 | 632_at | -0.1751 | 0.3347 | |
| GSE38129 | GSK3A | 2931 | 632_at | -0.0991 | 0.1365 | |
| GSE45670 | GSK3A | 2931 | 632_at | 0.1042 | 0.2469 | |
| GSE53622 | GSK3A | 2931 | 39564 | -0.1821 | 0.0030 | |
| GSE53624 | GSK3A | 2931 | 39564 | 0.1998 | 0.0004 | |
| GSE63941 | GSK3A | 2931 | 632_at | 0.6005 | 0.0016 | |
| GSE77861 | GSK3A | 2931 | 632_at | -0.0844 | 0.6040 | |
| GSE97050 | GSK3A | 2931 | A_24_P185394 | -0.0446 | 0.8550 | |
| SRP007169 | GSK3A | 2931 | RNAseq | -0.9519 | 0.0023 | |
| SRP008496 | GSK3A | 2931 | RNAseq | -0.9579 | 0.0000 | |
| SRP064894 | GSK3A | 2931 | RNAseq | 0.2464 | 0.2024 | |
| SRP133303 | GSK3A | 2931 | RNAseq | 0.2175 | 0.3148 | |
| SRP159526 | GSK3A | 2931 | RNAseq | 0.4317 | 0.0096 | |
| SRP193095 | GSK3A | 2931 | RNAseq | 0.1454 | 0.2850 | |
| SRP219564 | GSK3A | 2931 | RNAseq | -0.0827 | 0.7385 | |
| TCGA | GSK3A | 2931 | RNAseq | 0.0242 | 0.5926 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GSK3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GSK3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GSK3A | 2931 | 4 | 4 | 22 | |
| GSE20123 | GSK3A | 2931 | 4 | 3 | 23 | |
| GSE43470 | GSK3A | 2931 | 4 | 11 | 28 | |
| GSE46452 | GSK3A | 2931 | 47 | 1 | 11 | |
| GSE47630 | GSK3A | 2931 | 8 | 6 | 26 | |
| GSE54993 | GSK3A | 2931 | 17 | 4 | 49 | |
| GSE54994 | GSK3A | 2931 | 7 | 12 | 34 | |
| GSE60625 | GSK3A | 2931 | 9 | 0 | 2 | |
| GSE74703 | GSK3A | 2931 | 4 | 7 | 25 | |
| GSE74704 | GSK3A | 2931 | 4 | 1 | 15 | |
| TCGA | GSK3A | 2931 | 13 | 16 | 67 |
Total number of gains: 121; Total number of losses: 65; Total Number of normals: 302.
Somatic mutations of GSK3A:
Generating mutation plots.
Highly correlated genes for GSK3A:
Showing top 20/975 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GSK3A | KPNA1 | 0.795653 | 3 | 0 | 3 |
| GSK3A | UBE2O | 0.789101 | 3 | 0 | 3 |
| GSK3A | KRI1 | 0.772221 | 3 | 0 | 3 |
| GSK3A | ADCK1 | 0.771052 | 3 | 0 | 3 |
| GSK3A | NACC1 | 0.768347 | 3 | 0 | 3 |
| GSK3A | LENG8 | 0.762798 | 4 | 0 | 3 |
| GSK3A | CPLX1 | 0.758483 | 3 | 0 | 3 |
| GSK3A | FAM167B | 0.753492 | 3 | 0 | 3 |
| GSK3A | ALKBH6 | 0.751712 | 3 | 0 | 3 |
| GSK3A | PRR12 | 0.751552 | 4 | 0 | 4 |
| GSK3A | INPP5E | 0.743319 | 3 | 0 | 3 |
| GSK3A | RAD23A | 0.743145 | 4 | 0 | 4 |
| GSK3A | PI16 | 0.741725 | 3 | 0 | 3 |
| GSK3A | BSDC1 | 0.740394 | 3 | 0 | 3 |
| GSK3A | NAF1 | 0.73991 | 3 | 0 | 3 |
| GSK3A | DCTN1 | 0.738609 | 4 | 0 | 4 |
| GSK3A | CRTC2 | 0.738288 | 5 | 0 | 5 |
| GSK3A | RIOK1 | 0.737791 | 3 | 0 | 3 |
| GSK3A | MZF1 | 0.736623 | 4 | 0 | 3 |
| GSK3A | ZNF830 | 0.729272 | 3 | 0 | 3 |
For details and further investigation, click here
