JUN

 

Full name: Jun proto-oncogene, AP-1 transcription factor subunit Alias Symbol: c-Jun|AP-1
Type: protein-coding gene Cytoband: 1p32.1
Entrez ID: 3725 HGNC ID: HGNC:6204 Ensembl Gene: ENSG00000177606 OMIM ID: 165160
Drug and gene relationship at DGIdb
Screen Evidence:

 

JUN involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04024cAMP signaling pathway
hsa04210Apoptosis
hsa04310Wnt signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04620Toll-like receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04668TNF signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04921Oxytocin signaling pathway
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05132Salmonella infection
hsa05133Pertussis
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05161Hepatitis B
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05231Choline metabolism in cancer
hsa05321Inflammatory bowel disease (IBD)

 

Expression of JUN:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 JUN 3725 201464_x_at -0.5118 0.4115
GSE20347 JUN 3725 201464_x_at -0.0509 0.8499
GSE23400 JUN 3725 201464_x_at -0.0850 0.4823
GSE26886 JUN 3725 201464_x_at 0.9090 0.0034
GSE29001 JUN 3725 201464_x_at -0.2085 0.4374
GSE38129 JUN 3725 201464_x_at -0.2993 0.1750
GSE45670 JUN 3725 201464_x_at -0.7149 0.0148
GSE53622 JUN 3725 85800 -1.0034 0.0000
GSE53624 JUN 3725 85800 -0.6650 0.0000
GSE63941 JUN 3725 201464_x_at -1.1979 0.2028
GSE77861 JUN 3725 201464_x_at 0.1557 0.7723
GSE97050 JUN 3725 A_33_P3323298 -0.9482 0.2172
SRP007169 JUN 3725 RNAseq -1.0880 0.0267
SRP008496 JUN 3725 RNAseq -0.8750 0.0182
SRP064894 JUN 3725 RNAseq -0.0653 0.7773
SRP133303 JUN 3725 RNAseq -0.3240 0.3449
SRP159526 JUN 3725 RNAseq 0.0494 0.9311
SRP193095 JUN 3725 RNAseq 0.4479 0.0940
SRP219564 JUN 3725 RNAseq -0.0460 0.9447
TCGA JUN 3725 RNAseq -0.1388 0.0408

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by JUN expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of JUN:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 JUN 3725 3 5 22
GSE20123 JUN 3725 3 4 23
GSE43470 JUN 3725 6 2 35
GSE46452 JUN 3725 2 1 56
GSE47630 JUN 3725 8 5 27
GSE54993 JUN 3725 0 0 70
GSE54994 JUN 3725 8 2 43
GSE60625 JUN 3725 0 0 11
GSE74703 JUN 3725 5 2 29
GSE74704 JUN 3725 2 0 18
TCGA JUN 3725 10 18 68

Total number of gains: 47; Total number of losses: 39; Total Number of normals: 402.  

 

Somatic mutations of JUN:

 

Generating mutation plots.

 

Highly correlated genes for JUN:

 

Showing top 20/206 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
JUNC9orf470.767085303
JUNFOS0.75921212012
JUNKPNA10.731502303
JUNFEM1C0.716368403
JUNEGR10.7149311010
JUNTPBG0.689682303
JUNWSB10.682386303
JUNNRL0.674773303
JUNNR4A10.670038807
JUNLUC7L0.665582403
JUNRRAS20.6633303
JUNSLC25A250.661147403
JUNC5orf240.66072403
JUNCCDC400.654816404
JUNFOSB0.6515613012
JUNMATN40.650221303
JUNTRPC10.646188403
JUNCIC0.644626303
JUNGLI30.642918303
JUNWDR270.641944303

For details and further investigation, click here