| Full name: keratin 3 | Alias Symbol: CK3|K3 | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 3850 | HGNC ID: HGNC:6440 | Ensembl Gene: ENSG00000186442 | OMIM ID: 148043 |
| Drug and gene relationship at DGIdb | |||
Expression of KRT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KRT3 | 3850 | 217325_at | -0.1751 | 0.5682 | |
| GSE20347 | KRT3 | 3850 | 217325_at | -0.2068 | 0.0041 | |
| GSE23400 | KRT3 | 3850 | 217325_at | -0.3619 | 0.0000 | |
| GSE26886 | KRT3 | 3850 | 217325_at | 0.1512 | 0.2516 | |
| GSE29001 | KRT3 | 3850 | 217325_at | -0.1211 | 0.4653 | |
| GSE38129 | KRT3 | 3850 | 217325_at | -0.2289 | 0.0004 | |
| GSE45670 | KRT3 | 3850 | 217325_at | -0.2605 | 0.0304 | |
| GSE53622 | KRT3 | 3850 | 50548 | -0.3903 | 0.0000 | |
| GSE53624 | KRT3 | 3850 | 50548 | -0.6413 | 0.0000 | |
| GSE63941 | KRT3 | 3850 | 217325_at | -0.1033 | 0.5090 | |
| GSE77861 | KRT3 | 3850 | 217325_at | -0.3578 | 0.0809 | |
| GSE97050 | KRT3 | 3850 | A_33_P3287611 | -0.1070 | 0.6701 | |
| SRP007169 | KRT3 | 3850 | RNAseq | -4.6804 | 0.0000 | |
| SRP064894 | KRT3 | 3850 | RNAseq | -3.6590 | 0.0000 | |
| SRP133303 | KRT3 | 3850 | RNAseq | -3.6982 | 0.0000 | |
| SRP159526 | KRT3 | 3850 | RNAseq | -0.8521 | 0.3870 | |
| TCGA | KRT3 | 3850 | RNAseq | 2.8513 | 0.0005 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by KRT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KRT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KRT3 | 3850 | 8 | 1 | 21 | |
| GSE20123 | KRT3 | 3850 | 8 | 1 | 21 | |
| GSE43470 | KRT3 | 3850 | 3 | 0 | 40 | |
| GSE46452 | KRT3 | 3850 | 7 | 1 | 51 | |
| GSE47630 | KRT3 | 3850 | 10 | 2 | 28 | |
| GSE54993 | KRT3 | 3850 | 0 | 5 | 65 | |
| GSE54994 | KRT3 | 3850 | 4 | 1 | 48 | |
| GSE60625 | KRT3 | 3850 | 0 | 0 | 11 | |
| GSE74703 | KRT3 | 3850 | 3 | 0 | 33 | |
| GSE74704 | KRT3 | 3850 | 5 | 1 | 14 | |
| TCGA | KRT3 | 3850 | 13 | 11 | 72 |
Total number of gains: 61; Total number of losses: 23; Total Number of normals: 404.
Somatic mutations of KRT3:
Generating mutation plots.
Highly correlated genes for KRT3:
Showing top 20/574 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KRT3 | GPHB5 | 0.721091 | 4 | 0 | 4 |
| KRT3 | CLRN2 | 0.714663 | 3 | 0 | 3 |
| KRT3 | CHRD | 0.697852 | 4 | 0 | 4 |
| KRT3 | KLF17 | 0.685806 | 3 | 0 | 3 |
| KRT3 | CCDC172 | 0.684881 | 3 | 0 | 3 |
| KRT3 | BFSP2 | 0.676906 | 5 | 0 | 5 |
| KRT3 | CD164L2 | 0.674552 | 3 | 0 | 3 |
| KRT3 | COX4I2 | 0.674057 | 4 | 0 | 3 |
| KRT3 | PHF7 | 0.673452 | 4 | 0 | 4 |
| KRT3 | OR51T1 | 0.671449 | 3 | 0 | 3 |
| KRT3 | KRTAP10-8 | 0.67121 | 3 | 0 | 3 |
| KRT3 | FMN2 | 0.666537 | 4 | 0 | 4 |
| KRT3 | KANK2 | 0.666069 | 3 | 0 | 3 |
| KRT3 | KBTBD13 | 0.665973 | 3 | 0 | 3 |
| KRT3 | KRTAP6-1 | 0.664677 | 3 | 0 | 3 |
| KRT3 | KCNT1 | 0.663388 | 3 | 0 | 3 |
| KRT3 | CRYGN | 0.662598 | 3 | 0 | 3 |
| KRT3 | ZBTB45 | 0.662171 | 3 | 0 | 3 |
| KRT3 | UROC1 | 0.661876 | 4 | 0 | 4 |
| KRT3 | DUOXA2 | 0.661102 | 3 | 0 | 3 |
For details and further investigation, click here
