| Full name: dual oxidase maturation factor 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q21.1 | ||
| Entrez ID: 405753 | HGNC ID: HGNC:32698 | Ensembl Gene: ENSG00000140274 | OMIM ID: 612772 |
| Drug and gene relationship at DGIdb | |||
DUOXA2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04918 | Thyroid hormone synthesis |
Expression of DUOXA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DUOXA2 | 405753 | 230615_at | -0.3217 | 0.4522 | |
| GSE26886 | DUOXA2 | 405753 | 230615_at | -1.2383 | 0.0085 | |
| GSE45670 | DUOXA2 | 405753 | 230615_at | 0.7655 | 0.0181 | |
| GSE53622 | DUOXA2 | 405753 | 126953 | -0.2411 | 0.0111 | |
| GSE53624 | DUOXA2 | 405753 | 91613 | -0.5423 | 0.0000 | |
| GSE63941 | DUOXA2 | 405753 | 230615_at | 0.2472 | 0.0600 | |
| GSE77861 | DUOXA2 | 405753 | 230615_at | -0.2349 | 0.1728 | |
| GSE97050 | DUOXA2 | 405753 | A_33_P3275362 | -0.3286 | 0.1759 | |
| SRP064894 | DUOXA2 | 405753 | RNAseq | -2.8205 | 0.0000 | |
| SRP133303 | DUOXA2 | 405753 | RNAseq | -0.8194 | 0.0932 | |
| SRP159526 | DUOXA2 | 405753 | RNAseq | -3.7163 | 0.0001 | |
| SRP193095 | DUOXA2 | 405753 | RNAseq | -1.5214 | 0.0000 | |
| SRP219564 | DUOXA2 | 405753 | RNAseq | -1.6922 | 0.1502 | |
| TCGA | DUOXA2 | 405753 | RNAseq | -0.6054 | 0.0171 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by DUOXA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DUOXA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DUOXA2 | 405753 | 3 | 5 | 22 | |
| GSE20123 | DUOXA2 | 405753 | 3 | 5 | 22 | |
| GSE43470 | DUOXA2 | 405753 | 4 | 4 | 35 | |
| GSE46452 | DUOXA2 | 405753 | 3 | 7 | 49 | |
| GSE47630 | DUOXA2 | 405753 | 8 | 10 | 22 | |
| GSE54993 | DUOXA2 | 405753 | 5 | 5 | 60 | |
| GSE54994 | DUOXA2 | 405753 | 5 | 7 | 41 | |
| GSE60625 | DUOXA2 | 405753 | 4 | 0 | 7 | |
| GSE74703 | DUOXA2 | 405753 | 4 | 3 | 29 | |
| GSE74704 | DUOXA2 | 405753 | 1 | 3 | 16 | |
| TCGA | DUOXA2 | 405753 | 11 | 16 | 69 |
Total number of gains: 51; Total number of losses: 65; Total Number of normals: 372.
Somatic mutations of DUOXA2:
Generating mutation plots.
Highly correlated genes for DUOXA2:
Showing top 20/382 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DUOXA2 | JSRP1 | 0.798084 | 3 | 0 | 3 |
| DUOXA2 | PROCA1 | 0.779875 | 3 | 0 | 3 |
| DUOXA2 | LRFN2 | 0.771874 | 3 | 0 | 3 |
| DUOXA2 | AQP8 | 0.769166 | 3 | 0 | 3 |
| DUOXA2 | KCNJ13 | 0.768141 | 4 | 0 | 4 |
| DUOXA2 | SLC25A47 | 0.747839 | 3 | 0 | 3 |
| DUOXA2 | TGM6 | 0.745564 | 3 | 0 | 3 |
| DUOXA2 | LRRC46 | 0.744263 | 3 | 0 | 3 |
| DUOXA2 | TEX13A | 0.741762 | 3 | 0 | 3 |
| DUOXA2 | PHGR1 | 0.735913 | 3 | 0 | 3 |
| DUOXA2 | SPTBN4 | 0.733852 | 3 | 0 | 3 |
| DUOXA2 | FHIT | 0.73318 | 3 | 0 | 3 |
| DUOXA2 | DNAJB8 | 0.731903 | 3 | 0 | 3 |
| DUOXA2 | GJD4 | 0.730593 | 3 | 0 | 3 |
| DUOXA2 | BSND | 0.726978 | 3 | 0 | 3 |
| DUOXA2 | SLC22A31 | 0.725817 | 4 | 0 | 4 |
| DUOXA2 | CELF5 | 0.722735 | 3 | 0 | 3 |
| DUOXA2 | GALR2 | 0.722293 | 4 | 0 | 3 |
| DUOXA2 | RNF180 | 0.720279 | 3 | 0 | 3 |
| DUOXA2 | ADM2 | 0.720216 | 3 | 0 | 3 |
For details and further investigation, click here
