| Full name: chordin | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q27.1 | ||
| Entrez ID: 8646 | HGNC ID: HGNC:1949 | Ensembl Gene: ENSG00000090539 | OMIM ID: 603475 |
| Drug and gene relationship at DGIdb | |||
CHRD involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway |
Expression of CHRD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHRD | 8646 | 211248_s_at | -0.0433 | 0.8648 | |
| GSE20347 | CHRD | 8646 | 221674_s_at | 0.0370 | 0.6226 | |
| GSE23400 | CHRD | 8646 | 211248_s_at | -0.0181 | 0.6353 | |
| GSE26886 | CHRD | 8646 | 211248_s_at | 0.3693 | 0.0036 | |
| GSE29001 | CHRD | 8646 | 221674_s_at | -0.0494 | 0.7190 | |
| GSE38129 | CHRD | 8646 | 211248_s_at | -0.1510 | 0.0561 | |
| GSE45670 | CHRD | 8646 | 211248_s_at | -0.2624 | 0.0038 | |
| GSE53622 | CHRD | 8646 | 36026 | 0.1056 | 0.2622 | |
| GSE53624 | CHRD | 8646 | 36026 | 0.2007 | 0.0041 | |
| GSE63941 | CHRD | 8646 | 211248_s_at | -0.0604 | 0.7815 | |
| GSE77861 | CHRD | 8646 | 211248_s_at | -0.0778 | 0.5924 | |
| GSE97050 | CHRD | 8646 | A_23_P502047 | -0.0500 | 0.8653 | |
| SRP007169 | CHRD | 8646 | RNAseq | 3.3425 | 0.0069 | |
| SRP064894 | CHRD | 8646 | RNAseq | 0.6956 | 0.0392 | |
| SRP133303 | CHRD | 8646 | RNAseq | 0.0668 | 0.7661 | |
| SRP159526 | CHRD | 8646 | RNAseq | 0.4152 | 0.3344 | |
| SRP193095 | CHRD | 8646 | RNAseq | 0.7364 | 0.0008 | |
| SRP219564 | CHRD | 8646 | RNAseq | 0.4700 | 0.5405 | |
| TCGA | CHRD | 8646 | RNAseq | -0.6879 | 0.0009 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CHRD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHRD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHRD | 8646 | 25 | 0 | 5 | |
| GSE20123 | CHRD | 8646 | 25 | 0 | 5 | |
| GSE43470 | CHRD | 8646 | 25 | 0 | 18 | |
| GSE46452 | CHRD | 8646 | 19 | 1 | 39 | |
| GSE47630 | CHRD | 8646 | 27 | 2 | 11 | |
| GSE54993 | CHRD | 8646 | 1 | 19 | 50 | |
| GSE54994 | CHRD | 8646 | 41 | 0 | 12 | |
| GSE60625 | CHRD | 8646 | 0 | 6 | 5 | |
| GSE74703 | CHRD | 8646 | 21 | 0 | 15 | |
| GSE74704 | CHRD | 8646 | 17 | 0 | 3 | |
| TCGA | CHRD | 8646 | 77 | 0 | 19 |
Total number of gains: 278; Total number of losses: 28; Total Number of normals: 182.
Somatic mutations of CHRD:
Generating mutation plots.
Highly correlated genes for CHRD:
Showing top 20/654 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHRD | MYO18B | 0.784009 | 3 | 0 | 3 |
| CHRD | TMEM102 | 0.770499 | 3 | 0 | 3 |
| CHRD | PROC | 0.761079 | 3 | 0 | 3 |
| CHRD | VAV2 | 0.760654 | 3 | 0 | 3 |
| CHRD | ESPNL | 0.757138 | 3 | 0 | 3 |
| CHRD | CCDC42 | 0.753259 | 3 | 0 | 3 |
| CHRD | TMEM179 | 0.750907 | 3 | 0 | 3 |
| CHRD | MYBPH | 0.733931 | 3 | 0 | 3 |
| CHRD | ZGLP1 | 0.730888 | 3 | 0 | 3 |
| CHRD | NPEPL1 | 0.730651 | 4 | 0 | 4 |
| CHRD | OPRD1 | 0.728888 | 4 | 0 | 4 |
| CHRD | IGSF21 | 0.726247 | 4 | 0 | 4 |
| CHRD | TP73 | 0.721747 | 4 | 0 | 4 |
| CHRD | BRSK1 | 0.721045 | 3 | 0 | 3 |
| CHRD | CACNG8 | 0.720088 | 3 | 0 | 3 |
| CHRD | TRPV5 | 0.712548 | 3 | 0 | 3 |
| CHRD | AMN | 0.709696 | 6 | 0 | 5 |
| CHRD | LTC4S | 0.706945 | 3 | 0 | 3 |
| CHRD | NPTXR | 0.705393 | 5 | 0 | 5 |
| CHRD | CDRT15 | 0.70225 | 4 | 0 | 3 |
For details and further investigation, click here
