| Full name: urocanate hydratase 1 | Alias Symbol: FLJ31300|HMFN0320 | ||
| Type: protein-coding gene | Cytoband: 3q21.3 | ||
| Entrez ID: 131669 | HGNC ID: HGNC:26444 | Ensembl Gene: ENSG00000159650 | OMIM ID: 613012 |
| Drug and gene relationship at DGIdb | |||
Expression of UROC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UROC1 | 131669 | 1553341_at | -0.0083 | 0.9811 | |
| GSE26886 | UROC1 | 131669 | 1553341_at | -0.0126 | 0.9210 | |
| GSE45670 | UROC1 | 131669 | 1553341_at | 0.0543 | 0.4849 | |
| GSE53622 | UROC1 | 131669 | 93037 | -0.0081 | 0.9264 | |
| GSE53624 | UROC1 | 131669 | 93037 | 0.1672 | 0.0308 | |
| GSE63941 | UROC1 | 131669 | 1553341_at | -0.0590 | 0.6494 | |
| GSE77861 | UROC1 | 131669 | 1553341_at | -0.1663 | 0.1362 | |
| GSE97050 | UROC1 | 131669 | A_23_P422240 | 0.1807 | 0.5065 | |
| TCGA | UROC1 | 131669 | RNAseq | 2.1009 | 0.0258 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by UROC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UROC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UROC1 | 131669 | 17 | 0 | 13 | |
| GSE20123 | UROC1 | 131669 | 17 | 0 | 13 | |
| GSE43470 | UROC1 | 131669 | 19 | 0 | 24 | |
| GSE46452 | UROC1 | 131669 | 14 | 5 | 40 | |
| GSE47630 | UROC1 | 131669 | 17 | 4 | 19 | |
| GSE54993 | UROC1 | 131669 | 2 | 7 | 61 | |
| GSE54994 | UROC1 | 131669 | 31 | 3 | 19 | |
| GSE60625 | UROC1 | 131669 | 0 | 6 | 5 | |
| GSE74703 | UROC1 | 131669 | 17 | 0 | 19 | |
| GSE74704 | UROC1 | 131669 | 13 | 0 | 7 | |
| TCGA | UROC1 | 131669 | 55 | 6 | 35 |
Total number of gains: 202; Total number of losses: 31; Total Number of normals: 255.
Somatic mutations of UROC1:
Generating mutation plots.
Highly correlated genes for UROC1:
Showing top 20/183 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UROC1 | PROCA1 | 0.833678 | 3 | 0 | 3 |
| UROC1 | FAM71A | 0.784805 | 3 | 0 | 3 |
| UROC1 | CIB3 | 0.756331 | 3 | 0 | 3 |
| UROC1 | HHIP | 0.75449 | 4 | 0 | 3 |
| UROC1 | ABCB5 | 0.738979 | 3 | 0 | 3 |
| UROC1 | RGL4 | 0.737109 | 3 | 0 | 3 |
| UROC1 | CLEC1B | 0.717026 | 4 | 0 | 4 |
| UROC1 | HECW1 | 0.716965 | 4 | 0 | 4 |
| UROC1 | ISLR2 | 0.715653 | 3 | 0 | 3 |
| UROC1 | SCGN | 0.715628 | 3 | 0 | 3 |
| UROC1 | C10orf67 | 0.71506 | 3 | 0 | 3 |
| UROC1 | FNDC9 | 0.700454 | 3 | 0 | 3 |
| UROC1 | NRG3 | 0.70028 | 3 | 0 | 3 |
| UROC1 | TMEM151B | 0.700231 | 4 | 0 | 3 |
| UROC1 | C3orf35 | 0.700105 | 3 | 0 | 3 |
| UROC1 | VRTN | 0.697777 | 3 | 0 | 3 |
| UROC1 | SIX3 | 0.69751 | 3 | 0 | 3 |
| UROC1 | PRODH2 | 0.689427 | 3 | 0 | 3 |
| UROC1 | MEP1A | 0.68936 | 3 | 0 | 3 |
| UROC1 | OR10H1 | 0.687114 | 4 | 0 | 4 |
For details and further investigation, click here
