| Full name: CLN3 lysosomal/endosomal transmembrane protein, battenin | Alias Symbol: JNCL|BTN1 | ||
| Type: protein-coding gene | Cytoband: 16p12.1 | ||
| Entrez ID: 1201 | HGNC ID: HGNC:2074 | Ensembl Gene: ENSG00000188603 | OMIM ID: 607042 |
| Drug and gene relationship at DGIdb | |||
Expression of CLN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLN3 | 1201 | 209275_s_at | 0.0964 | 0.8592 | |
| GSE20347 | CLN3 | 1201 | 209275_s_at | 0.1291 | 0.3642 | |
| GSE23400 | CLN3 | 1201 | 210859_x_at | 0.2413 | 0.0001 | |
| GSE26886 | CLN3 | 1201 | 209275_s_at | -0.4748 | 0.0393 | |
| GSE29001 | CLN3 | 1201 | 209275_s_at | 0.2083 | 0.4861 | |
| GSE38129 | CLN3 | 1201 | 209275_s_at | 0.2475 | 0.0229 | |
| GSE45670 | CLN3 | 1201 | 209275_s_at | 0.3376 | 0.0093 | |
| GSE63941 | CLN3 | 1201 | 209275_s_at | 0.5809 | 0.1528 | |
| GSE77861 | CLN3 | 1201 | 209275_s_at | 0.0329 | 0.9022 | |
| GSE97050 | CLN3 | 1201 | A_24_P187651 | 0.2734 | 0.2798 | |
| SRP007169 | CLN3 | 1201 | RNAseq | -0.3972 | 0.2597 | |
| SRP008496 | CLN3 | 1201 | RNAseq | -0.3767 | 0.0839 | |
| SRP064894 | CLN3 | 1201 | RNAseq | 0.5967 | 0.0230 | |
| SRP133303 | CLN3 | 1201 | RNAseq | 0.1038 | 0.5216 | |
| SRP159526 | CLN3 | 1201 | RNAseq | 0.0946 | 0.5343 | |
| SRP193095 | CLN3 | 1201 | RNAseq | -0.0279 | 0.8109 | |
| SRP219564 | CLN3 | 1201 | RNAseq | 0.4195 | 0.0558 | |
| TCGA | CLN3 | 1201 | RNAseq | -0.0237 | 0.6593 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CLN3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CLN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLN3 | 1201 | 4 | 5 | 21 | |
| GSE20123 | CLN3 | 1201 | 4 | 4 | 22 | |
| GSE43470 | CLN3 | 1201 | 4 | 3 | 36 | |
| GSE46452 | CLN3 | 1201 | 38 | 1 | 20 | |
| GSE47630 | CLN3 | 1201 | 11 | 7 | 22 | |
| GSE54993 | CLN3 | 1201 | 3 | 5 | 62 | |
| GSE54994 | CLN3 | 1201 | 4 | 9 | 40 | |
| GSE60625 | CLN3 | 1201 | 4 | 0 | 7 | |
| GSE74703 | CLN3 | 1201 | 4 | 2 | 30 | |
| GSE74704 | CLN3 | 1201 | 3 | 2 | 15 | |
| TCGA | CLN3 | 1201 | 20 | 12 | 64 |
Total number of gains: 99; Total number of losses: 50; Total Number of normals: 339.
Somatic mutations of CLN3:
Generating mutation plots.
Highly correlated genes for CLN3:
Showing top 20/106 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLN3 | STK16 | 0.787462 | 3 | 0 | 3 |
| CLN3 | BRAF | 0.761862 | 3 | 0 | 3 |
| CLN3 | TMUB1 | 0.759129 | 4 | 0 | 4 |
| CLN3 | NUDT22 | 0.752482 | 3 | 0 | 3 |
| CLN3 | PMPCA | 0.737144 | 3 | 0 | 3 |
| CLN3 | B9D1 | 0.721254 | 4 | 0 | 4 |
| CLN3 | HMBS | 0.712231 | 3 | 0 | 3 |
| CLN3 | LAMTOR2 | 0.708203 | 3 | 0 | 3 |
| CLN3 | SETD1B | 0.702562 | 4 | 0 | 3 |
| CLN3 | DYRK1B | 0.692883 | 3 | 0 | 3 |
| CLN3 | UBN2 | 0.686848 | 3 | 0 | 3 |
| CLN3 | PARS2 | 0.684202 | 4 | 0 | 4 |
| CLN3 | C1QL1 | 0.673308 | 3 | 0 | 3 |
| CLN3 | AIFM3 | 0.661139 | 4 | 0 | 3 |
| CLN3 | TMEM125 | 0.660813 | 4 | 0 | 3 |
| CLN3 | ALDH16A1 | 0.65959 | 4 | 0 | 3 |
| CLN3 | FERD3L | 0.655148 | 3 | 0 | 3 |
| CLN3 | POM121L12 | 0.655102 | 3 | 0 | 3 |
| CLN3 | KAT8 | 0.653835 | 6 | 0 | 6 |
| CLN3 | RXRB | 0.647243 | 4 | 0 | 3 |
For details and further investigation, click here
