| Full name: lipoic acid synthetase | Alias Symbol: LAS | ||
| Type: protein-coding gene | Cytoband: 4p14 | ||
| Entrez ID: 11019 | HGNC ID: HGNC:16429 | Ensembl Gene: ENSG00000121897 | OMIM ID: 607031 |
| Drug and gene relationship at DGIdb | |||
Expression of LIAS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LIAS | 11019 | 214045_at | -1.0504 | 0.0426 | |
| GSE20347 | LIAS | 11019 | 214045_at | -0.7367 | 0.0000 | |
| GSE23400 | LIAS | 11019 | 214045_at | -0.1998 | 0.0000 | |
| GSE26886 | LIAS | 11019 | 214045_at | -1.8388 | 0.0000 | |
| GSE29001 | LIAS | 11019 | 214045_at | -0.6130 | 0.1173 | |
| GSE38129 | LIAS | 11019 | 214045_at | -0.6111 | 0.0003 | |
| GSE45670 | LIAS | 11019 | 214045_at | -0.4842 | 0.0479 | |
| GSE53622 | LIAS | 11019 | 130162 | -0.6667 | 0.0000 | |
| GSE53624 | LIAS | 11019 | 130162 | -0.6762 | 0.0000 | |
| GSE63941 | LIAS | 11019 | 214045_at | 0.5930 | 0.3314 | |
| GSE77861 | LIAS | 11019 | 214045_at | -0.4510 | 0.0809 | |
| GSE97050 | LIAS | 11019 | A_23_P254081 | -0.3249 | 0.1859 | |
| SRP007169 | LIAS | 11019 | RNAseq | -1.2240 | 0.0142 | |
| SRP008496 | LIAS | 11019 | RNAseq | -1.4438 | 0.0045 | |
| SRP064894 | LIAS | 11019 | RNAseq | -0.8229 | 0.0000 | |
| SRP133303 | LIAS | 11019 | RNAseq | -0.4762 | 0.0041 | |
| SRP159526 | LIAS | 11019 | RNAseq | -1.1058 | 0.0005 | |
| SRP193095 | LIAS | 11019 | RNAseq | -0.7644 | 0.0000 | |
| SRP219564 | LIAS | 11019 | RNAseq | -0.5255 | 0.0933 | |
| TCGA | LIAS | 11019 | RNAseq | -0.2015 | 0.0074 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by LIAS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LIAS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LIAS | 11019 | 0 | 16 | 14 | |
| GSE20123 | LIAS | 11019 | 0 | 16 | 14 | |
| GSE43470 | LIAS | 11019 | 0 | 15 | 28 | |
| GSE46452 | LIAS | 11019 | 1 | 36 | 22 | |
| GSE47630 | LIAS | 11019 | 1 | 19 | 20 | |
| GSE54993 | LIAS | 11019 | 8 | 0 | 62 | |
| GSE54994 | LIAS | 11019 | 3 | 10 | 40 | |
| GSE60625 | LIAS | 11019 | 0 | 0 | 11 | |
| GSE74703 | LIAS | 11019 | 0 | 12 | 24 | |
| GSE74704 | LIAS | 11019 | 0 | 9 | 11 | |
| TCGA | LIAS | 11019 | 10 | 45 | 41 |
Total number of gains: 23; Total number of losses: 178; Total Number of normals: 287.
Somatic mutations of LIAS:
Generating mutation plots.
Highly correlated genes for LIAS:
Showing top 20/315 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LIAS | BUD13 | 0.7043 | 3 | 0 | 3 |
| LIAS | ADAMTS17 | 0.693785 | 3 | 0 | 3 |
| LIAS | DNASE1 | 0.692871 | 3 | 0 | 3 |
| LIAS | UBXN6 | 0.676821 | 3 | 0 | 3 |
| LIAS | TMEM184A | 0.668485 | 4 | 0 | 3 |
| LIAS | SUDS3 | 0.660462 | 3 | 0 | 3 |
| LIAS | TULP2 | 0.65359 | 4 | 0 | 3 |
| LIAS | PHAX | 0.648983 | 4 | 0 | 3 |
| LIAS | PRSS27 | 0.645663 | 6 | 0 | 6 |
| LIAS | TMEM125 | 0.643632 | 4 | 0 | 4 |
| LIAS | SOX6 | 0.642896 | 5 | 0 | 4 |
| LIAS | PARD6B | 0.638956 | 3 | 0 | 3 |
| LIAS | RHBG | 0.638561 | 3 | 0 | 3 |
| LIAS | KCNK3 | 0.632475 | 3 | 0 | 3 |
| LIAS | USP46 | 0.630273 | 7 | 0 | 6 |
| LIAS | ZNF326 | 0.630184 | 4 | 0 | 3 |
| LIAS | NDRG2 | 0.630171 | 8 | 0 | 7 |
| LIAS | ENTPD5 | 0.629278 | 9 | 0 | 9 |
| LIAS | CYSRT1 | 0.629165 | 5 | 0 | 4 |
| LIAS | VSIG10L | 0.625292 | 6 | 0 | 5 |
For details and further investigation, click here
