| Full name: NDRG family member 2 | Alias Symbol: KIAA1248|SYLD | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 57447 | HGNC ID: HGNC:14460 | Ensembl Gene: ENSG00000165795 | OMIM ID: 605272 |
| Drug and gene relationship at DGIdb | |||
Expression of NDRG2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NDRG2 | 57447 | 206453_s_at | -1.3464 | 0.0083 | |
| GSE20347 | NDRG2 | 57447 | 206453_s_at | -1.3796 | 0.0000 | |
| GSE23400 | NDRG2 | 57447 | 206453_s_at | -1.3055 | 0.0000 | |
| GSE26886 | NDRG2 | 57447 | 206453_s_at | -2.5412 | 0.0000 | |
| GSE29001 | NDRG2 | 57447 | 206453_s_at | -0.9937 | 0.0585 | |
| GSE38129 | NDRG2 | 57447 | 206453_s_at | -1.4085 | 0.0000 | |
| GSE45670 | NDRG2 | 57447 | 206453_s_at | -0.7011 | 0.0047 | |
| GSE53622 | NDRG2 | 57447 | 16503 | -1.6455 | 0.0000 | |
| GSE53624 | NDRG2 | 57447 | 45844 | -2.1368 | 0.0000 | |
| GSE63941 | NDRG2 | 57447 | 206453_s_at | 1.2398 | 0.0769 | |
| GSE77861 | NDRG2 | 57447 | 206453_s_at | -0.7227 | 0.1828 | |
| GSE97050 | NDRG2 | 57447 | A_33_P3383233 | -1.0084 | 0.1670 | |
| SRP007169 | NDRG2 | 57447 | RNAseq | -3.0892 | 0.0000 | |
| SRP008496 | NDRG2 | 57447 | RNAseq | -3.2717 | 0.0000 | |
| SRP064894 | NDRG2 | 57447 | RNAseq | -1.9987 | 0.0000 | |
| SRP133303 | NDRG2 | 57447 | RNAseq | -2.1389 | 0.0000 | |
| SRP159526 | NDRG2 | 57447 | RNAseq | -1.6451 | 0.0007 | |
| SRP193095 | NDRG2 | 57447 | RNAseq | -2.2998 | 0.0000 | |
| SRP219564 | NDRG2 | 57447 | RNAseq | -1.8722 | 0.0000 | |
| TCGA | NDRG2 | 57447 | RNAseq | -0.4657 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by NDRG2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NDRG2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NDRG2 | 57447 | 9 | 3 | 18 | |
| GSE20123 | NDRG2 | 57447 | 8 | 3 | 19 | |
| GSE43470 | NDRG2 | 57447 | 7 | 1 | 35 | |
| GSE46452 | NDRG2 | 57447 | 19 | 2 | 38 | |
| GSE47630 | NDRG2 | 57447 | 10 | 10 | 20 | |
| GSE54993 | NDRG2 | 57447 | 3 | 11 | 56 | |
| GSE54994 | NDRG2 | 57447 | 18 | 5 | 30 | |
| GSE60625 | NDRG2 | 57447 | 0 | 2 | 9 | |
| GSE74703 | NDRG2 | 57447 | 6 | 1 | 29 | |
| GSE74704 | NDRG2 | 57447 | 4 | 2 | 14 | |
| TCGA | NDRG2 | 57447 | 27 | 16 | 53 |
Total number of gains: 111; Total number of losses: 56; Total Number of normals: 321.
Somatic mutations of NDRG2:
Generating mutation plots.
Highly correlated genes for NDRG2:
Showing top 20/868 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NDRG2 | MYZAP | 0.806946 | 3 | 0 | 3 |
| NDRG2 | SH3BGRL2 | 0.78994 | 6 | 0 | 5 |
| NDRG2 | SMIM5 | 0.786497 | 6 | 0 | 6 |
| NDRG2 | FAM163B | 0.784644 | 3 | 0 | 3 |
| NDRG2 | VSIG10L | 0.777861 | 7 | 0 | 7 |
| NDRG2 | FAM214A | 0.774657 | 6 | 0 | 6 |
| NDRG2 | GPX6 | 0.771511 | 3 | 0 | 3 |
| NDRG2 | MUC22 | 0.768166 | 3 | 0 | 3 |
| NDRG2 | ANXA9 | 0.767865 | 10 | 0 | 10 |
| NDRG2 | KRTAP20-1 | 0.757392 | 3 | 0 | 3 |
| NDRG2 | EPHX2 | 0.749295 | 10 | 0 | 10 |
| NDRG2 | CYSRT1 | 0.747629 | 6 | 0 | 6 |
| NDRG2 | ZNF431 | 0.745643 | 4 | 0 | 4 |
| NDRG2 | CRISP3 | 0.745478 | 10 | 0 | 9 |
| NDRG2 | OR2Z1 | 0.745031 | 3 | 0 | 3 |
| NDRG2 | CGNL1 | 0.740644 | 6 | 0 | 6 |
| NDRG2 | COBL | 0.739502 | 9 | 0 | 9 |
| NDRG2 | ABLIM1 | 0.738464 | 11 | 0 | 10 |
| NDRG2 | IL36A | 0.738435 | 11 | 0 | 10 |
| NDRG2 | DEGS2 | 0.735518 | 8 | 0 | 8 |
For details and further investigation, click here
