| Full name: deoxyribonuclease 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 1773 | HGNC ID: HGNC:2956 | Ensembl Gene: ENSG00000213918 | OMIM ID: 125505 |
| Drug and gene relationship at DGIdb | |||
Expression of DNASE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNASE1 | 1773 | 1558546_at | -0.2151 | 0.4291 | |
| GSE20347 | DNASE1 | 1773 | 210165_at | -0.2851 | 0.0005 | |
| GSE23400 | DNASE1 | 1773 | 210165_at | -0.2172 | 0.0000 | |
| GSE26886 | DNASE1 | 1773 | 228929_at | -0.1298 | 0.4170 | |
| GSE29001 | DNASE1 | 1773 | 210165_at | -0.3581 | 0.0102 | |
| GSE38129 | DNASE1 | 1773 | 210165_at | -0.3226 | 0.0125 | |
| GSE45670 | DNASE1 | 1773 | 1558546_at | 0.2047 | 0.0070 | |
| GSE53622 | DNASE1 | 1773 | 58360 | 0.0323 | 0.6795 | |
| GSE53624 | DNASE1 | 1773 | 58360 | -0.3018 | 0.0001 | |
| GSE63941 | DNASE1 | 1773 | 228929_at | -0.2583 | 0.6494 | |
| GSE77861 | DNASE1 | 1773 | 228929_at | -0.1113 | 0.3779 | |
| GSE97050 | DNASE1 | 1773 | A_23_P66311 | 0.2821 | 0.1939 | |
| SRP007169 | DNASE1 | 1773 | RNAseq | -0.7283 | 0.2583 | |
| SRP064894 | DNASE1 | 1773 | RNAseq | -0.4198 | 0.1079 | |
| SRP133303 | DNASE1 | 1773 | RNAseq | -0.0239 | 0.9224 | |
| SRP159526 | DNASE1 | 1773 | RNAseq | 0.1792 | 0.5616 | |
| SRP193095 | DNASE1 | 1773 | RNAseq | -0.0971 | 0.5820 | |
| SRP219564 | DNASE1 | 1773 | RNAseq | -0.6611 | 0.1882 | |
| TCGA | DNASE1 | 1773 | RNAseq | -0.6292 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DNASE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DNASE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNASE1 | 1773 | 5 | 5 | 20 | |
| GSE20123 | DNASE1 | 1773 | 5 | 4 | 21 | |
| GSE43470 | DNASE1 | 1773 | 4 | 7 | 32 | |
| GSE46452 | DNASE1 | 1773 | 38 | 1 | 20 | |
| GSE47630 | DNASE1 | 1773 | 13 | 6 | 21 | |
| GSE54993 | DNASE1 | 1773 | 4 | 5 | 61 | |
| GSE54994 | DNASE1 | 1773 | 5 | 9 | 39 | |
| GSE60625 | DNASE1 | 1773 | 4 | 0 | 7 | |
| GSE74703 | DNASE1 | 1773 | 4 | 5 | 27 | |
| GSE74704 | DNASE1 | 1773 | 3 | 2 | 15 | |
| TCGA | DNASE1 | 1773 | 19 | 14 | 63 |
Total number of gains: 104; Total number of losses: 58; Total Number of normals: 326.
Somatic mutations of DNASE1:
Generating mutation plots.
Highly correlated genes for DNASE1:
Showing top 20/236 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNASE1 | SRCIN1 | 0.70108 | 3 | 0 | 3 |
| DNASE1 | LIAS | 0.692871 | 3 | 0 | 3 |
| DNASE1 | GPR25 | 0.67638 | 4 | 0 | 4 |
| DNASE1 | RGR | 0.675641 | 4 | 0 | 4 |
| DNASE1 | FBXO34 | 0.669671 | 4 | 0 | 4 |
| DNASE1 | FUT6 | 0.66498 | 3 | 0 | 3 |
| DNASE1 | CRYAA | 0.663661 | 3 | 0 | 3 |
| DNASE1 | CNGB1 | 0.65423 | 4 | 0 | 3 |
| DNASE1 | ZNF624 | 0.653387 | 3 | 0 | 3 |
| DNASE1 | ABLIM3 | 0.652682 | 5 | 0 | 4 |
| DNASE1 | IL23A | 0.648056 | 5 | 0 | 3 |
| DNASE1 | SLC7A4 | 0.647285 | 3 | 0 | 3 |
| DNASE1 | SRD5A2 | 0.644047 | 4 | 0 | 3 |
| DNASE1 | CD1A | 0.641769 | 3 | 0 | 3 |
| DNASE1 | AQP4 | 0.639934 | 5 | 0 | 4 |
| DNASE1 | CHI3L2 | 0.639627 | 3 | 0 | 3 |
| DNASE1 | CYP2E1 | 0.636066 | 5 | 0 | 4 |
| DNASE1 | KLK3 | 0.634991 | 4 | 0 | 3 |
| DNASE1 | PAOX | 0.634058 | 5 | 0 | 3 |
| DNASE1 | NUDT16L1 | 0.632822 | 4 | 0 | 3 |
For details and further investigation, click here
