| Full name: serine protease 27 | Alias Symbol: MPN|CAPH2 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 83886 | HGNC ID: HGNC:15475 | Ensembl Gene: ENSG00000172382 | OMIM ID: 608018 |
| Drug and gene relationship at DGIdb | |||
Expression of PRSS27:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRSS27 | 83886 | 232074_at | -3.5600 | 0.0683 | |
| GSE26886 | PRSS27 | 83886 | 232074_at | -6.3686 | 0.0000 | |
| GSE45670 | PRSS27 | 83886 | 232074_at | -1.2560 | 0.0789 | |
| GSE53622 | PRSS27 | 83886 | 131695 | -3.9067 | 0.0000 | |
| GSE53624 | PRSS27 | 83886 | 131695 | -4.5856 | 0.0000 | |
| GSE63941 | PRSS27 | 83886 | 232074_at | 0.5841 | 0.0188 | |
| GSE77861 | PRSS27 | 83886 | 232074_at | -3.0837 | 0.0011 | |
| GSE97050 | PRSS27 | 83886 | A_23_P106806 | -1.2954 | 0.1729 | |
| SRP007169 | PRSS27 | 83886 | RNAseq | -6.6274 | 0.0000 | |
| SRP008496 | PRSS27 | 83886 | RNAseq | -6.7771 | 0.0000 | |
| SRP064894 | PRSS27 | 83886 | RNAseq | -4.7859 | 0.0000 | |
| SRP133303 | PRSS27 | 83886 | RNAseq | -5.1732 | 0.0000 | |
| SRP159526 | PRSS27 | 83886 | RNAseq | -6.3667 | 0.0000 | |
| SRP219564 | PRSS27 | 83886 | RNAseq | -4.5858 | 0.0001 | |
| TCGA | PRSS27 | 83886 | RNAseq | 0.3203 | 0.3700 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by PRSS27 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRSS27:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRSS27 | 83886 | 5 | 5 | 20 | |
| GSE20123 | PRSS27 | 83886 | 5 | 4 | 21 | |
| GSE43470 | PRSS27 | 83886 | 4 | 7 | 32 | |
| GSE46452 | PRSS27 | 83886 | 38 | 1 | 20 | |
| GSE47630 | PRSS27 | 83886 | 13 | 6 | 21 | |
| GSE54993 | PRSS27 | 83886 | 3 | 5 | 62 | |
| GSE54994 | PRSS27 | 83886 | 5 | 9 | 39 | |
| GSE60625 | PRSS27 | 83886 | 4 | 0 | 7 | |
| GSE74703 | PRSS27 | 83886 | 4 | 5 | 27 | |
| GSE74704 | PRSS27 | 83886 | 3 | 2 | 15 | |
| TCGA | PRSS27 | 83886 | 19 | 13 | 64 |
Total number of gains: 103; Total number of losses: 57; Total Number of normals: 328.
Somatic mutations of PRSS27:
Generating mutation plots.
Highly correlated genes for PRSS27:
Showing top 20/1104 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRSS27 | VSIG10L | 0.927726 | 7 | 0 | 7 |
| PRSS27 | NCCRP1 | 0.922475 | 4 | 0 | 4 |
| PRSS27 | CLCA4 | 0.921577 | 8 | 0 | 8 |
| PRSS27 | CAPN14 | 0.919518 | 7 | 0 | 7 |
| PRSS27 | IL36A | 0.913486 | 7 | 0 | 7 |
| PRSS27 | TMPRSS11B | 0.912042 | 8 | 0 | 8 |
| PRSS27 | SPINK5 | 0.909767 | 8 | 0 | 8 |
| PRSS27 | NCR1 | 0.908129 | 3 | 0 | 3 |
| PRSS27 | LYPD2 | 0.904912 | 3 | 0 | 3 |
| PRSS27 | EPS8L2 | 0.904695 | 7 | 0 | 7 |
| PRSS27 | CRNN | 0.904236 | 8 | 0 | 8 |
| PRSS27 | MAL | 0.900837 | 8 | 0 | 8 |
| PRSS27 | SPINK7 | 0.897556 | 8 | 0 | 8 |
| PRSS27 | SCEL | 0.895596 | 9 | 0 | 9 |
| PRSS27 | KLK13 | 0.894469 | 8 | 0 | 8 |
| PRSS27 | RANBP9 | 0.893798 | 6 | 0 | 6 |
| PRSS27 | LYNX1 | 0.891701 | 8 | 0 | 8 |
| PRSS27 | KRT78 | 0.890629 | 8 | 0 | 8 |
| PRSS27 | MUC21 | 0.887804 | 3 | 0 | 3 |
| PRSS27 | CNFN | 0.884227 | 8 | 0 | 8 |
For details and further investigation, click here
