| Full name: par-6 family cell polarity regulator beta | Alias Symbol: PAR-6B | ||
| Type: protein-coding gene | Cytoband: 20q13.13 | ||
| Entrez ID: 84612 | HGNC ID: HGNC:16245 | Ensembl Gene: ENSG00000124171 | OMIM ID: 608975 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PARD6B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway | |
| hsa04360 | Axon guidance | |
| hsa04530 | Tight junction |
Expression of PARD6B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PARD6B | 84612 | 235165_at | 0.1289 | 0.8781 | |
| GSE20347 | PARD6B | 84612 | 211907_s_at | -0.0395 | 0.5331 | |
| GSE23400 | PARD6B | 84612 | 211907_s_at | -0.2160 | 0.0000 | |
| GSE26886 | PARD6B | 84612 | 235165_at | -2.0814 | 0.0000 | |
| GSE29001 | PARD6B | 84612 | 214827_at | -0.0616 | 0.7404 | |
| GSE38129 | PARD6B | 84612 | 211907_s_at | -0.0776 | 0.2707 | |
| GSE45670 | PARD6B | 84612 | 235165_at | -0.3871 | 0.1914 | |
| GSE53622 | PARD6B | 84612 | 28613 | -0.7508 | 0.0000 | |
| GSE53624 | PARD6B | 84612 | 28613 | -1.4645 | 0.0000 | |
| GSE63941 | PARD6B | 84612 | 235165_at | 1.3621 | 0.0816 | |
| GSE77861 | PARD6B | 84612 | 235165_at | -1.2137 | 0.0204 | |
| SRP007169 | PARD6B | 84612 | RNAseq | -2.4476 | 0.0000 | |
| SRP008496 | PARD6B | 84612 | RNAseq | -2.2557 | 0.0000 | |
| SRP064894 | PARD6B | 84612 | RNAseq | -1.7461 | 0.0000 | |
| SRP133303 | PARD6B | 84612 | RNAseq | -0.4008 | 0.0605 | |
| SRP159526 | PARD6B | 84612 | RNAseq | -0.2572 | 0.6588 | |
| SRP193095 | PARD6B | 84612 | RNAseq | -1.2889 | 0.0000 | |
| SRP219564 | PARD6B | 84612 | RNAseq | -0.7316 | 0.2805 | |
| TCGA | PARD6B | 84612 | RNAseq | -0.3477 | 0.0022 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by PARD6B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PARD6B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PARD6B | 84612 | 16 | 2 | 12 | |
| GSE20123 | PARD6B | 84612 | 16 | 2 | 12 | |
| GSE43470 | PARD6B | 84612 | 13 | 0 | 30 | |
| GSE46452 | PARD6B | 84612 | 29 | 0 | 30 | |
| GSE47630 | PARD6B | 84612 | 24 | 1 | 15 | |
| GSE54993 | PARD6B | 84612 | 0 | 17 | 53 | |
| GSE54994 | PARD6B | 84612 | 27 | 0 | 26 | |
| GSE60625 | PARD6B | 84612 | 0 | 0 | 11 | |
| GSE74703 | PARD6B | 84612 | 11 | 0 | 25 | |
| GSE74704 | PARD6B | 84612 | 12 | 0 | 8 | |
| TCGA | PARD6B | 84612 | 46 | 3 | 47 |
Total number of gains: 194; Total number of losses: 25; Total Number of normals: 269.
Somatic mutations of PARD6B:
Generating mutation plots.
Highly correlated genes for PARD6B:
Showing top 20/735 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PARD6B | STX7 | 0.754701 | 3 | 0 | 3 |
| PARD6B | TMEM234 | 0.752987 | 3 | 0 | 3 |
| PARD6B | HACE1 | 0.712699 | 3 | 0 | 3 |
| PARD6B | TMEM45B | 0.707364 | 4 | 0 | 4 |
| PARD6B | EPS15 | 0.707073 | 3 | 0 | 3 |
| PARD6B | ZNF780A | 0.706124 | 3 | 0 | 3 |
| PARD6B | ZNF416 | 0.695837 | 4 | 0 | 4 |
| PARD6B | AKTIP | 0.689156 | 4 | 0 | 3 |
| PARD6B | RASSF5 | 0.688594 | 5 | 0 | 5 |
| PARD6B | GABRP | 0.683392 | 3 | 0 | 3 |
| PARD6B | TAB3 | 0.677321 | 6 | 0 | 6 |
| PARD6B | ELMO2 | 0.671159 | 7 | 0 | 5 |
| PARD6B | MACC1 | 0.671137 | 6 | 0 | 5 |
| PARD6B | SEZ6L | 0.670379 | 3 | 0 | 3 |
| PARD6B | GRM6 | 0.668175 | 5 | 0 | 5 |
| PARD6B | HMGN1 | 0.667752 | 3 | 0 | 3 |
| PARD6B | C11orf16 | 0.662141 | 3 | 0 | 3 |
| PARD6B | ARPC3 | 0.659242 | 6 | 0 | 4 |
| PARD6B | AGFG2 | 0.658593 | 6 | 0 | 6 |
| PARD6B | SNX3 | 0.654916 | 4 | 0 | 4 |
For details and further investigation, click here
