| Full name: ADAM metallopeptidase with thrombospondin type 1 motif 17 | Alias Symbol: FLJ32769|FLJ16363 | ||
| Type: protein-coding gene | Cytoband: 15q26.3 | ||
| Entrez ID: 170691 | HGNC ID: HGNC:17109 | Ensembl Gene: ENSG00000140470 | OMIM ID: 607511 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAMTS17:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAMTS17 | 170691 | 1552727_s_at | -0.2785 | 0.8036 | |
| GSE26886 | ADAMTS17 | 170691 | 1552727_s_at | -0.8393 | 0.0180 | |
| GSE45670 | ADAMTS17 | 170691 | 1552727_s_at | -0.8280 | 0.0135 | |
| GSE63941 | ADAMTS17 | 170691 | 1552725_s_at | -0.0404 | 0.8159 | |
| GSE77861 | ADAMTS17 | 170691 | 1552725_s_at | -0.2642 | 0.0561 | |
| GSE97050 | ADAMTS17 | 170691 | A_33_P3241051 | -0.3150 | 0.3083 | |
| SRP007169 | ADAMTS17 | 170691 | RNAseq | -1.3612 | 0.0210 | |
| SRP064894 | ADAMTS17 | 170691 | RNAseq | -1.2899 | 0.0000 | |
| SRP133303 | ADAMTS17 | 170691 | RNAseq | -1.1293 | 0.0000 | |
| SRP159526 | ADAMTS17 | 170691 | RNAseq | 0.1419 | 0.7973 | |
| SRP193095 | ADAMTS17 | 170691 | RNAseq | -0.6917 | 0.0007 | |
| SRP219564 | ADAMTS17 | 170691 | RNAseq | -0.1731 | 0.7697 | |
| TCGA | ADAMTS17 | 170691 | RNAseq | -0.2663 | 0.1299 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by ADAMTS17 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ADAMTS17:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAMTS17 | 170691 | 7 | 2 | 21 | |
| GSE20123 | ADAMTS17 | 170691 | 7 | 2 | 21 | |
| GSE43470 | ADAMTS17 | 170691 | 6 | 5 | 32 | |
| GSE46452 | ADAMTS17 | 170691 | 3 | 7 | 49 | |
| GSE47630 | ADAMTS17 | 170691 | 9 | 10 | 21 | |
| GSE54993 | ADAMTS17 | 170691 | 4 | 7 | 59 | |
| GSE54994 | ADAMTS17 | 170691 | 8 | 7 | 38 | |
| GSE60625 | ADAMTS17 | 170691 | 4 | 0 | 7 | |
| GSE74703 | ADAMTS17 | 170691 | 5 | 4 | 27 | |
| GSE74704 | ADAMTS17 | 170691 | 3 | 3 | 14 | |
| TCGA | ADAMTS17 | 170691 | 18 | 12 | 66 |
Total number of gains: 74; Total number of losses: 59; Total Number of normals: 355.
Somatic mutations of ADAMTS17:
Generating mutation plots.
Highly correlated genes for ADAMTS17:
Showing top 20/132 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAMTS17 | PAX8 | 0.722556 | 3 | 0 | 3 |
| ADAMTS17 | GALK1 | 0.720723 | 3 | 0 | 3 |
| ADAMTS17 | APOM | 0.717884 | 3 | 0 | 3 |
| ADAMTS17 | SEMA5A | 0.711902 | 3 | 0 | 3 |
| ADAMTS17 | SIX2 | 0.706513 | 3 | 0 | 3 |
| ADAMTS17 | FBXO34 | 0.700932 | 5 | 0 | 4 |
| ADAMTS17 | LIAS | 0.693785 | 3 | 0 | 3 |
| ADAMTS17 | CD9 | 0.692992 | 3 | 0 | 3 |
| ADAMTS17 | IRGQ | 0.686716 | 3 | 0 | 3 |
| ADAMTS17 | JMJD8 | 0.679319 | 4 | 0 | 3 |
| ADAMTS17 | PDZD2 | 0.679057 | 4 | 0 | 4 |
| ADAMTS17 | ZNF780A | 0.673092 | 3 | 0 | 3 |
| ADAMTS17 | NCAN | 0.672615 | 3 | 0 | 3 |
| ADAMTS17 | HECTD1 | 0.669106 | 5 | 0 | 5 |
| ADAMTS17 | RTKN2 | 0.665519 | 4 | 0 | 4 |
| ADAMTS17 | ATP6V0A4 | 0.663144 | 3 | 0 | 3 |
| ADAMTS17 | BRAF | 0.662578 | 4 | 0 | 3 |
| ADAMTS17 | RIPK4 | 0.658411 | 4 | 0 | 4 |
| ADAMTS17 | MACC1 | 0.656436 | 3 | 0 | 3 |
| ADAMTS17 | GAB2 | 0.656 | 4 | 0 | 3 |
For details and further investigation, click here
