| Full name: ubiquitin specific peptidase 46 | Alias Symbol: FLJ12552 | ||
| Type: protein-coding gene | Cytoband: 4q12 | ||
| Entrez ID: 64854 | HGNC ID: HGNC:20075 | Ensembl Gene: ENSG00000109189 | OMIM ID: 612849 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of USP46:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | USP46 | 64854 | 203869_at | 0.1908 | 0.8782 | |
| GSE20347 | USP46 | 64854 | 203870_at | -1.6918 | 0.0000 | |
| GSE23400 | USP46 | 64854 | 219943_s_at | -0.1569 | 0.0000 | |
| GSE26886 | USP46 | 64854 | 203870_at | -3.0147 | 0.0000 | |
| GSE29001 | USP46 | 64854 | 203870_at | -1.1871 | 0.0013 | |
| GSE38129 | USP46 | 64854 | 203870_at | -1.1170 | 0.0000 | |
| GSE45670 | USP46 | 64854 | 203870_at | -0.4661 | 0.1477 | |
| GSE53622 | USP46 | 64854 | 16760 | -0.9406 | 0.0000 | |
| GSE53624 | USP46 | 64854 | 16760 | -1.2230 | 0.0000 | |
| GSE63941 | USP46 | 64854 | 203869_at | -2.3060 | 0.0009 | |
| GSE77861 | USP46 | 64854 | 203870_at | -1.7973 | 0.0004 | |
| SRP007169 | USP46 | 64854 | RNAseq | -2.4079 | 0.0000 | |
| SRP008496 | USP46 | 64854 | RNAseq | -2.0013 | 0.0000 | |
| SRP064894 | USP46 | 64854 | RNAseq | -1.1762 | 0.0000 | |
| SRP133303 | USP46 | 64854 | RNAseq | -0.6950 | 0.0000 | |
| SRP159526 | USP46 | 64854 | RNAseq | -0.9979 | 0.0006 | |
| SRP193095 | USP46 | 64854 | RNAseq | -0.8862 | 0.0000 | |
| SRP219564 | USP46 | 64854 | RNAseq | -1.5640 | 0.0016 | |
| TCGA | USP46 | 64854 | RNAseq | -0.1406 | 0.0401 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by USP46 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of USP46:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | USP46 | 64854 | 4 | 11 | 15 | |
| GSE20123 | USP46 | 64854 | 3 | 11 | 16 | |
| GSE43470 | USP46 | 64854 | 0 | 14 | 29 | |
| GSE46452 | USP46 | 64854 | 1 | 36 | 22 | |
| GSE47630 | USP46 | 64854 | 1 | 18 | 21 | |
| GSE54993 | USP46 | 64854 | 7 | 0 | 63 | |
| GSE54994 | USP46 | 64854 | 2 | 10 | 41 | |
| GSE60625 | USP46 | 64854 | 0 | 0 | 11 | |
| GSE74703 | USP46 | 64854 | 0 | 12 | 24 | |
| GSE74704 | USP46 | 64854 | 2 | 6 | 12 | |
| TCGA | USP46 | 64854 | 18 | 29 | 49 |
Total number of gains: 38; Total number of losses: 147; Total Number of normals: 303.
Somatic mutations of USP46:
Generating mutation plots.
Highly correlated genes for USP46:
Showing top 20/1065 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| USP46 | SNORA68 | 0.760542 | 3 | 0 | 3 |
| USP46 | DNAJC5 | 0.756832 | 3 | 0 | 3 |
| USP46 | GBP6 | 0.735483 | 3 | 0 | 3 |
| USP46 | USP46-AS1 | 0.735466 | 7 | 0 | 7 |
| USP46 | SH3BGRL2 | 0.733965 | 5 | 0 | 5 |
| USP46 | FAM214A | 0.733839 | 5 | 0 | 5 |
| USP46 | SNX24 | 0.733697 | 7 | 0 | 7 |
| USP46 | TET2 | 0.733209 | 5 | 0 | 5 |
| USP46 | CLCN3 | 0.732554 | 8 | 0 | 8 |
| USP46 | LNX1 | 0.729982 | 6 | 0 | 5 |
| USP46 | RAB10 | 0.721033 | 5 | 0 | 5 |
| USP46 | ZNRF1 | 0.720151 | 4 | 0 | 4 |
| USP46 | SLC44A3 | 0.719533 | 6 | 0 | 6 |
| USP46 | FCHO2 | 0.71901 | 5 | 0 | 5 |
| USP46 | HBP1 | 0.717506 | 7 | 0 | 6 |
| USP46 | SHROOM3 | 0.716364 | 5 | 0 | 4 |
| USP46 | PDIK1L | 0.714007 | 5 | 0 | 4 |
| USP46 | USO1 | 0.713994 | 9 | 0 | 9 |
| USP46 | CAPN14 | 0.713507 | 5 | 0 | 5 |
| USP46 | PITHD1 | 0.713367 | 5 | 0 | 4 |
For details and further investigation, click here
