| Full name: SRY-box transcription factor 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11p15.3 | ||
| Entrez ID: 55553 | HGNC ID: HGNC:16421 | Ensembl Gene: ENSG00000110693 | OMIM ID: 607257 |
| Drug and gene relationship at DGIdb | |||
Expression of SOX6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOX6 | 55553 | 228214_at | -1.3204 | 0.0579 | |
| GSE26886 | SOX6 | 55553 | 227497_at | -1.6614 | 0.0000 | |
| GSE45670 | SOX6 | 55553 | 228214_at | -0.8266 | 0.0106 | |
| GSE53622 | SOX6 | 55553 | 21547 | -1.7895 | 0.0000 | |
| GSE53624 | SOX6 | 55553 | 21547 | -1.7606 | 0.0000 | |
| GSE63941 | SOX6 | 55553 | 228214_at | -0.8285 | 0.2542 | |
| GSE77861 | SOX6 | 55553 | 228214_at | -0.4087 | 0.2177 | |
| GSE97050 | SOX6 | 55553 | A_33_P3233916 | -0.1408 | 0.6209 | |
| SRP007169 | SOX6 | 55553 | RNAseq | -1.1628 | 0.1755 | |
| SRP064894 | SOX6 | 55553 | RNAseq | -1.9100 | 0.0000 | |
| SRP133303 | SOX6 | 55553 | RNAseq | -1.6487 | 0.0000 | |
| SRP159526 | SOX6 | 55553 | RNAseq | -0.9780 | 0.1645 | |
| SRP193095 | SOX6 | 55553 | RNAseq | -1.6641 | 0.0000 | |
| SRP219564 | SOX6 | 55553 | RNAseq | -1.1444 | 0.0741 | |
| TCGA | SOX6 | 55553 | RNAseq | 0.0582 | 0.8049 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by SOX6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOX6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOX6 | 55553 | 0 | 10 | 20 | |
| GSE20123 | SOX6 | 55553 | 0 | 10 | 20 | |
| GSE43470 | SOX6 | 55553 | 1 | 5 | 37 | |
| GSE46452 | SOX6 | 55553 | 7 | 5 | 47 | |
| GSE47630 | SOX6 | 55553 | 3 | 11 | 26 | |
| GSE54993 | SOX6 | 55553 | 3 | 0 | 67 | |
| GSE54994 | SOX6 | 55553 | 4 | 12 | 37 | |
| GSE60625 | SOX6 | 55553 | 0 | 0 | 11 | |
| GSE74703 | SOX6 | 55553 | 1 | 3 | 32 | |
| GSE74704 | SOX6 | 55553 | 0 | 9 | 11 | |
| TCGA | SOX6 | 55553 | 11 | 32 | 53 |
Total number of gains: 30; Total number of losses: 97; Total Number of normals: 361.
Somatic mutations of SOX6:
Generating mutation plots.
Highly correlated genes for SOX6:
Showing top 20/343 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOX6 | KSR1 | 0.840302 | 3 | 0 | 3 |
| SOX6 | GLIDR | 0.733064 | 3 | 0 | 3 |
| SOX6 | KDM6A | 0.731121 | 3 | 0 | 3 |
| SOX6 | SULT2B1 | 0.717989 | 4 | 0 | 4 |
| SOX6 | HCAR3 | 0.71238 | 3 | 0 | 3 |
| SOX6 | ZNF569 | 0.704912 | 3 | 0 | 3 |
| SOX6 | MYH14 | 0.690529 | 3 | 0 | 3 |
| SOX6 | WDR44 | 0.688326 | 4 | 0 | 3 |
| SOX6 | ABCC8 | 0.687932 | 3 | 0 | 3 |
| SOX6 | CLTCL1 | 0.686631 | 3 | 0 | 3 |
| SOX6 | PRSS8 | 0.686125 | 4 | 0 | 4 |
| SOX6 | CAPNS2 | 0.682261 | 4 | 0 | 3 |
| SOX6 | CYP4F12 | 0.680679 | 5 | 0 | 5 |
| SOX6 | DRD3 | 0.67919 | 3 | 0 | 3 |
| SOX6 | ZNF831 | 0.675458 | 3 | 0 | 3 |
| SOX6 | NICN1 | 0.674393 | 3 | 0 | 3 |
| SOX6 | ADAMTSL4 | 0.67321 | 5 | 0 | 4 |
| SOX6 | CEACAM1 | 0.668554 | 6 | 0 | 5 |
| SOX6 | CYP3A5 | 0.667241 | 7 | 0 | 6 |
| SOX6 | ANKRD22 | 0.666535 | 3 | 0 | 3 |
For details and further investigation, click here
