| Full name: LIM zinc finger domain containing 1 | Alias Symbol: PINCH|PINCH1 | ||
| Type: protein-coding gene | Cytoband: 2q12.3 | ||
| Entrez ID: 3987 | HGNC ID: HGNC:6616 | Ensembl Gene: ENSG00000169756 | OMIM ID: 602567 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LIMS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LIMS1 | 3987 | 1570259_at | 0.4668 | 0.6570 | |
| GSE26886 | LIMS1 | 3987 | 1566129_at | 0.3629 | 0.2903 | |
| GSE45670 | LIMS1 | 3987 | 1566129_at | -0.2255 | 0.1900 | |
| GSE53622 | LIMS1 | 3987 | 24140 | 0.2010 | 0.0001 | |
| GSE53624 | LIMS1 | 3987 | 56278 | 0.4038 | 0.0000 | |
| GSE63941 | LIMS1 | 3987 | 1566129_at | -0.7770 | 0.0007 | |
| GSE97050 | LIMS1 | 3987 | A_23_P210358 | 0.3655 | 0.1907 | |
| SRP007169 | LIMS1 | 3987 | RNAseq | 1.3196 | 0.0010 | |
| SRP008496 | LIMS1 | 3987 | RNAseq | 2.1404 | 0.0000 | |
| SRP064894 | LIMS1 | 3987 | RNAseq | 0.4865 | 0.0535 | |
| SRP133303 | LIMS1 | 3987 | RNAseq | 0.7181 | 0.0000 | |
| SRP159526 | LIMS1 | 3987 | RNAseq | 0.2772 | 0.3172 | |
| SRP193095 | LIMS1 | 3987 | RNAseq | 0.3298 | 0.0108 | |
| SRP219564 | LIMS1 | 3987 | RNAseq | 0.3188 | 0.3257 | |
| TCGA | LIMS1 | 3987 | RNAseq | 0.0156 | 0.8025 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LIMS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LIMS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LIMS1 | 3987 | 4 | 2 | 24 | |
| GSE20123 | LIMS1 | 3987 | 4 | 2 | 24 | |
| GSE43470 | LIMS1 | 3987 | 3 | 1 | 39 | |
| GSE46452 | LIMS1 | 3987 | 1 | 4 | 54 | |
| GSE47630 | LIMS1 | 3987 | 7 | 0 | 33 | |
| GSE54993 | LIMS1 | 3987 | 0 | 6 | 64 | |
| GSE54994 | LIMS1 | 3987 | 10 | 0 | 43 | |
| GSE60625 | LIMS1 | 3987 | 0 | 3 | 8 | |
| GSE74703 | LIMS1 | 3987 | 3 | 1 | 32 | |
| GSE74704 | LIMS1 | 3987 | 2 | 2 | 16 | |
| TCGA | LIMS1 | 3987 | 31 | 6 | 59 |
Total number of gains: 65; Total number of losses: 27; Total Number of normals: 396.
Somatic mutations of LIMS1:
Generating mutation plots.
Highly correlated genes for LIMS1:
Showing top 20/165 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LIMS1 | ANKHD1 | 0.86948 | 3 | 0 | 3 |
| LIMS1 | UBXN2A | 0.816389 | 3 | 0 | 3 |
| LIMS1 | ZBED6 | 0.786971 | 3 | 0 | 3 |
| LIMS1 | C6orf163 | 0.785739 | 3 | 0 | 3 |
| LIMS1 | SMYD2 | 0.764594 | 3 | 0 | 3 |
| LIMS1 | COMMD5 | 0.750371 | 3 | 0 | 3 |
| LIMS1 | RAB7B | 0.746911 | 3 | 0 | 3 |
| LIMS1 | PODNL1 | 0.73796 | 4 | 0 | 3 |
| LIMS1 | MRPL32 | 0.728679 | 3 | 0 | 3 |
| LIMS1 | PTPN4 | 0.726037 | 3 | 0 | 3 |
| LIMS1 | MTCP1 | 0.710764 | 3 | 0 | 3 |
| LIMS1 | EIF4G3 | 0.710671 | 3 | 0 | 3 |
| LIMS1 | ARF1 | 0.710625 | 3 | 0 | 3 |
| LIMS1 | ZNF251 | 0.710253 | 3 | 0 | 3 |
| LIMS1 | ANKRD36B | 0.70835 | 4 | 0 | 4 |
| LIMS1 | CHD1L | 0.70765 | 3 | 0 | 3 |
| LIMS1 | PIAS4 | 0.70762 | 3 | 0 | 3 |
| LIMS1 | CNP | 0.697241 | 3 | 0 | 3 |
| LIMS1 | STAMBPL1 | 0.69653 | 3 | 0 | 3 |
| LIMS1 | PMS1 | 0.694758 | 3 | 0 | 3 |
For details and further investigation, click here
