| Full name: chromodomain helicase DNA binding protein 1 like | Alias Symbol: ALC1 | ||
| Type: protein-coding gene | Cytoband: 1q21.1 | ||
| Entrez ID: 9557 | HGNC ID: HGNC:1916 | Ensembl Gene: ENSG00000131778 | OMIM ID: 613039 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CHD1L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHD1L | 9557 | 212539_at | 0.5521 | 0.0995 | |
| GSE20347 | CHD1L | 9557 | 212539_at | 0.7094 | 0.0000 | |
| GSE23400 | CHD1L | 9557 | 212539_at | 0.6811 | 0.0000 | |
| GSE26886 | CHD1L | 9557 | 212539_at | 0.3152 | 0.2879 | |
| GSE29001 | CHD1L | 9557 | 212539_at | 0.7487 | 0.0090 | |
| GSE38129 | CHD1L | 9557 | 212539_at | 0.7300 | 0.0000 | |
| GSE45670 | CHD1L | 9557 | 212539_at | 0.3834 | 0.0383 | |
| GSE53622 | CHD1L | 9557 | 20637 | 0.6805 | 0.0000 | |
| GSE53624 | CHD1L | 9557 | 35629 | 0.6726 | 0.0000 | |
| GSE63941 | CHD1L | 9557 | 212539_at | -0.3927 | 0.4875 | |
| GSE77861 | CHD1L | 9557 | 212539_at | 0.9912 | 0.0009 | |
| GSE97050 | CHD1L | 9557 | A_23_P45831 | 0.4381 | 0.1711 | |
| SRP007169 | CHD1L | 9557 | RNAseq | 0.6428 | 0.0955 | |
| SRP008496 | CHD1L | 9557 | RNAseq | 1.0926 | 0.0001 | |
| SRP064894 | CHD1L | 9557 | RNAseq | 0.5479 | 0.0001 | |
| SRP133303 | CHD1L | 9557 | RNAseq | 0.5701 | 0.0019 | |
| SRP159526 | CHD1L | 9557 | RNAseq | 0.7124 | 0.0021 | |
| SRP193095 | CHD1L | 9557 | RNAseq | 0.2389 | 0.0587 | |
| SRP219564 | CHD1L | 9557 | RNAseq | 0.9077 | 0.0022 | |
| TCGA | CHD1L | 9557 | RNAseq | -0.0012 | 0.9811 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CHD1L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHD1L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHD1L | 9557 | 12 | 0 | 18 | |
| GSE20123 | CHD1L | 9557 | 12 | 0 | 18 | |
| GSE43470 | CHD1L | 9557 | 5 | 1 | 37 | |
| GSE46452 | CHD1L | 9557 | 2 | 1 | 56 | |
| GSE47630 | CHD1L | 9557 | 12 | 2 | 26 | |
| GSE54993 | CHD1L | 9557 | 0 | 2 | 68 | |
| GSE54994 | CHD1L | 9557 | 15 | 0 | 38 | |
| GSE60625 | CHD1L | 9557 | 0 | 0 | 11 | |
| GSE74703 | CHD1L | 9557 | 5 | 1 | 30 | |
| GSE74704 | CHD1L | 9557 | 6 | 0 | 14 | |
| TCGA | CHD1L | 9557 | 33 | 15 | 48 |
Total number of gains: 102; Total number of losses: 22; Total Number of normals: 364.
Somatic mutations of CHD1L:
Generating mutation plots.
Highly correlated genes for CHD1L:
Showing top 20/1973 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHD1L | CCDC127 | 0.829137 | 3 | 0 | 3 |
| CHD1L | SLC39A3 | 0.822419 | 3 | 0 | 3 |
| CHD1L | CMTM4 | 0.771017 | 4 | 0 | 4 |
| CHD1L | ZNRF3 | 0.766766 | 3 | 0 | 3 |
| CHD1L | WDR54 | 0.765253 | 5 | 0 | 5 |
| CHD1L | ZNF579 | 0.761897 | 3 | 0 | 3 |
| CHD1L | UTP23 | 0.754021 | 6 | 0 | 5 |
| CHD1L | GNPNAT1 | 0.747481 | 3 | 0 | 3 |
| CHD1L | CDCA7 | 0.747131 | 5 | 0 | 5 |
| CHD1L | DDX59 | 0.746372 | 3 | 0 | 3 |
| CHD1L | NF1 | 0.745656 | 3 | 0 | 3 |
| CHD1L | FMNL2 | 0.744468 | 6 | 0 | 6 |
| CHD1L | GORAB | 0.744412 | 7 | 0 | 7 |
| CHD1L | SCNM1 | 0.7434 | 3 | 0 | 3 |
| CHD1L | ALKBH6 | 0.742576 | 4 | 0 | 4 |
| CHD1L | PYCR2 | 0.741215 | 3 | 0 | 3 |
| CHD1L | DHRSX | 0.739392 | 4 | 0 | 4 |
| CHD1L | PFDN2 | 0.739041 | 10 | 0 | 9 |
| CHD1L | PGM2L1 | 0.736749 | 4 | 0 | 4 |
| CHD1L | TTC39C | 0.735952 | 3 | 0 | 3 |
For details and further investigation, click here
