| Full name: eukaryotic translation initiation factor 4 gamma 3 | Alias Symbol: eIF4GII | ||
| Type: protein-coding gene | Cytoband: 1p36.12 | ||
| Entrez ID: 8672 | HGNC ID: HGNC:3298 | Ensembl Gene: ENSG00000075151 | OMIM ID: 603929 |
| Drug and gene relationship at DGIdb | |||
Expression of EIF4G3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF4G3 | 8672 | 201935_s_at | -0.0195 | 0.9676 | |
| GSE20347 | EIF4G3 | 8672 | 201936_s_at | -0.2430 | 0.0838 | |
| GSE23400 | EIF4G3 | 8672 | 201935_s_at | 0.0913 | 0.2712 | |
| GSE26886 | EIF4G3 | 8672 | 201935_s_at | 0.0134 | 0.9612 | |
| GSE29001 | EIF4G3 | 8672 | 201935_s_at | 0.1449 | 0.6914 | |
| GSE38129 | EIF4G3 | 8672 | 201935_s_at | -0.1027 | 0.3329 | |
| GSE45670 | EIF4G3 | 8672 | 201935_s_at | 0.1098 | 0.4532 | |
| GSE53622 | EIF4G3 | 8672 | 9852 | -0.0944 | 0.1211 | |
| GSE53624 | EIF4G3 | 8672 | 10065 | 0.0390 | 0.6543 | |
| GSE63941 | EIF4G3 | 8672 | 201935_s_at | -2.3629 | 0.0001 | |
| GSE77861 | EIF4G3 | 8672 | 201935_s_at | -0.0091 | 0.9717 | |
| GSE97050 | EIF4G3 | 8672 | A_24_P383850 | -0.0444 | 0.8721 | |
| SRP007169 | EIF4G3 | 8672 | RNAseq | -0.1957 | 0.5932 | |
| SRP008496 | EIF4G3 | 8672 | RNAseq | 0.1084 | 0.6499 | |
| SRP064894 | EIF4G3 | 8672 | RNAseq | 0.1965 | 0.4277 | |
| SRP133303 | EIF4G3 | 8672 | RNAseq | 0.1882 | 0.0655 | |
| SRP159526 | EIF4G3 | 8672 | RNAseq | 0.1190 | 0.6353 | |
| SRP193095 | EIF4G3 | 8672 | RNAseq | 0.0643 | 0.5246 | |
| SRP219564 | EIF4G3 | 8672 | RNAseq | -0.1672 | 0.5765 | |
| TCGA | EIF4G3 | 8672 | RNAseq | -0.0038 | 0.9328 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by EIF4G3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF4G3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF4G3 | 8672 | 0 | 5 | 25 | |
| GSE20123 | EIF4G3 | 8672 | 0 | 4 | 26 | |
| GSE43470 | EIF4G3 | 8672 | 0 | 8 | 35 | |
| GSE46452 | EIF4G3 | 8672 | 5 | 1 | 53 | |
| GSE47630 | EIF4G3 | 8672 | 8 | 3 | 29 | |
| GSE54993 | EIF4G3 | 8672 | 3 | 1 | 66 | |
| GSE54994 | EIF4G3 | 8672 | 11 | 4 | 38 | |
| GSE60625 | EIF4G3 | 8672 | 0 | 0 | 11 | |
| GSE74703 | EIF4G3 | 8672 | 0 | 5 | 31 | |
| GSE74704 | EIF4G3 | 8672 | 0 | 0 | 20 | |
| TCGA | EIF4G3 | 8672 | 9 | 23 | 64 |
Total number of gains: 36; Total number of losses: 54; Total Number of normals: 398.
Somatic mutations of EIF4G3:
Generating mutation plots.
Highly correlated genes for EIF4G3:
Showing top 20/245 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF4G3 | BBS4 | 0.810135 | 3 | 0 | 3 |
| EIF4G3 | ZNF583 | 0.783185 | 3 | 0 | 3 |
| EIF4G3 | CHL1 | 0.782492 | 3 | 0 | 3 |
| EIF4G3 | ARMCX2 | 0.771065 | 3 | 0 | 3 |
| EIF4G3 | CHUK | 0.758298 | 3 | 0 | 3 |
| EIF4G3 | TMEM129 | 0.756481 | 3 | 0 | 3 |
| EIF4G3 | TSNAX | 0.756358 | 3 | 0 | 3 |
| EIF4G3 | FNDC3A | 0.755906 | 3 | 0 | 3 |
| EIF4G3 | LACTB | 0.746662 | 3 | 0 | 3 |
| EIF4G3 | ITGA1 | 0.745295 | 3 | 0 | 3 |
| EIF4G3 | PPIL4 | 0.744177 | 3 | 0 | 3 |
| EIF4G3 | DPY19L3 | 0.742649 | 3 | 0 | 3 |
| EIF4G3 | MLLT1 | 0.742312 | 3 | 0 | 3 |
| EIF4G3 | CD44 | 0.733347 | 3 | 0 | 3 |
| EIF4G3 | TNRC6A | 0.729366 | 4 | 0 | 4 |
| EIF4G3 | RRM2B | 0.728765 | 3 | 0 | 3 |
| EIF4G3 | SLC37A3 | 0.724132 | 4 | 0 | 4 |
| EIF4G3 | ACSL4 | 0.721029 | 4 | 0 | 3 |
| EIF4G3 | RSRC2 | 0.720463 | 3 | 0 | 3 |
| EIF4G3 | VPS26B | 0.712141 | 3 | 0 | 3 |
For details and further investigation, click here
