| Full name: ADP ribosylation factor 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q42.13 | ||
| Entrez ID: 375 | HGNC ID: HGNC:652 | Ensembl Gene: ENSG00000143761 | OMIM ID: 103180 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ARF1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04072 | Phospholipase D signaling pathway |
Expression of ARF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARF1 | 375 | 232175_at | 0.2254 | 0.7202 | |
| GSE26886 | ARF1 | 375 | 232175_at | -0.0782 | 0.7490 | |
| GSE45670 | ARF1 | 375 | 232175_at | 0.5719 | 0.0000 | |
| GSE53622 | ARF1 | 375 | 46878 | -0.3534 | 0.0000 | |
| GSE53624 | ARF1 | 375 | 46878 | 0.0044 | 0.9320 | |
| GSE63941 | ARF1 | 375 | 232175_at | 0.0115 | 0.9703 | |
| GSE77861 | ARF1 | 375 | 232175_at | 0.1293 | 0.3081 | |
| GSE97050 | ARF1 | 375 | A_23_P201086 | -0.0203 | 0.9524 | |
| SRP007169 | ARF1 | 375 | RNAseq | -1.4545 | 0.0000 | |
| SRP008496 | ARF1 | 375 | RNAseq | -1.2921 | 0.0000 | |
| SRP064894 | ARF1 | 375 | RNAseq | -0.0570 | 0.6968 | |
| SRP133303 | ARF1 | 375 | RNAseq | 0.0577 | 0.6364 | |
| SRP159526 | ARF1 | 375 | RNAseq | -0.1479 | 0.6191 | |
| SRP193095 | ARF1 | 375 | RNAseq | -0.3589 | 0.0051 | |
| SRP219564 | ARF1 | 375 | RNAseq | 0.0894 | 0.7071 | |
| TCGA | ARF1 | 375 | RNAseq | 0.0245 | 0.5041 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ARF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARF1 | 375 | 11 | 0 | 19 | |
| GSE20123 | ARF1 | 375 | 11 | 0 | 19 | |
| GSE43470 | ARF1 | 375 | 7 | 1 | 35 | |
| GSE46452 | ARF1 | 375 | 3 | 2 | 54 | |
| GSE47630 | ARF1 | 375 | 15 | 0 | 25 | |
| GSE54993 | ARF1 | 375 | 0 | 6 | 64 | |
| GSE54994 | ARF1 | 375 | 17 | 0 | 36 | |
| GSE60625 | ARF1 | 375 | 0 | 0 | 11 | |
| GSE74703 | ARF1 | 375 | 7 | 1 | 28 | |
| GSE74704 | ARF1 | 375 | 5 | 0 | 15 | |
| TCGA | ARF1 | 375 | 45 | 2 | 49 |
Total number of gains: 121; Total number of losses: 12; Total Number of normals: 355.
Somatic mutations of ARF1:
Generating mutation plots.
Highly correlated genes for ARF1:
Showing top 20/163 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARF1 | ZNF417 | 0.806706 | 3 | 0 | 3 |
| ARF1 | AAK1 | 0.799359 | 3 | 0 | 3 |
| ARF1 | CHD8 | 0.7855 | 3 | 0 | 3 |
| ARF1 | INPP5E | 0.772674 | 3 | 0 | 3 |
| ARF1 | SNRNP70 | 0.749406 | 3 | 0 | 3 |
| ARF1 | AKAP8L | 0.749077 | 3 | 0 | 3 |
| ARF1 | REC8 | 0.742131 | 4 | 0 | 4 |
| ARF1 | MIER2 | 0.73915 | 3 | 0 | 3 |
| ARF1 | LENG8 | 0.73786 | 4 | 0 | 4 |
| ARF1 | MAP4K4 | 0.733328 | 3 | 0 | 3 |
| ARF1 | SLC39A3 | 0.729357 | 3 | 0 | 3 |
| ARF1 | FASTKD1 | 0.72373 | 3 | 0 | 3 |
| ARF1 | MDN1 | 0.71947 | 3 | 0 | 3 |
| ARF1 | ZNF124 | 0.718244 | 3 | 0 | 3 |
| ARF1 | KDM6B | 0.717867 | 3 | 0 | 3 |
| ARF1 | SH2B2 | 0.716806 | 4 | 0 | 4 |
| ARF1 | TRIM28 | 0.711077 | 3 | 0 | 3 |
| ARF1 | LIMS1 | 0.710625 | 3 | 0 | 3 |
| ARF1 | KHSRP | 0.709059 | 3 | 0 | 3 |
| ARF1 | IRF7 | 0.7057 | 3 | 0 | 3 |
For details and further investigation, click here
