PMS1

 

Full name: PMS1 homolog 1, mismatch repair system component Alias Symbol: MLH2
Type: protein-coding gene Cytoband: 2q32.2
Entrez ID: 5378 HGNC ID: HGNC:9121 Ensembl Gene: ENSG00000064933 OMIM ID: 600258
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of PMS1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PMS1 5378 213677_s_at 0.4858 0.1778
GSE20347 PMS1 5378 213677_s_at 0.5494 0.0055
GSE23400 PMS1 5378 213677_s_at 0.4510 0.0001
GSE26886 PMS1 5378 213677_s_at 0.3741 0.2300
GSE29001 PMS1 5378 213677_s_at 0.4652 0.2231
GSE38129 PMS1 5378 213677_s_at 0.4996 0.0016
GSE45670 PMS1 5378 213677_s_at 0.1008 0.6031
GSE53622 PMS1 5378 102948 0.1005 0.3365
GSE53624 PMS1 5378 34968 0.3181 0.0000
GSE63941 PMS1 5378 213677_s_at 0.1830 0.7976
GSE77861 PMS1 5378 213677_s_at 0.2896 0.4764
GSE97050 PMS1 5378 A_33_P3250463 0.1122 0.7684
SRP007169 PMS1 5378 RNAseq 0.4313 0.3513
SRP008496 PMS1 5378 RNAseq 0.3262 0.2265
SRP064894 PMS1 5378 RNAseq 0.3177 0.0748
SRP133303 PMS1 5378 RNAseq 0.0542 0.6342
SRP159526 PMS1 5378 RNAseq -0.2192 0.3603
SRP193095 PMS1 5378 RNAseq -0.1091 0.2063
SRP219564 PMS1 5378 RNAseq -0.0711 0.8109
TCGA PMS1 5378 RNAseq 0.0375 0.5338

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PMS1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PMS1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PMS1 5378 9 3 18
GSE20123 PMS1 5378 9 3 18
GSE43470 PMS1 5378 3 1 39
GSE46452 PMS1 5378 1 4 54
GSE47630 PMS1 5378 4 5 31
GSE54993 PMS1 5378 0 5 65
GSE54994 PMS1 5378 12 6 35
GSE60625 PMS1 5378 0 3 8
GSE74703 PMS1 5378 2 1 33
GSE74704 PMS1 5378 3 3 14
TCGA PMS1 5378 24 7 65

Total number of gains: 67; Total number of losses: 41; Total Number of normals: 380.  

 

Somatic mutations of PMS1:

 

Generating mutation plots.

 

Highly correlated genes for PMS1:

 

Showing top 20/701 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PMS1CISD20.815036303
PMS1CMTM40.814316303
PMS1TMEM1810.811606303
PMS1DHRSX0.796291303
PMS1CHD80.79182303
PMS1CCDC1270.780707303
PMS1SLC25A370.757476303
PMS1EVL0.751386303
PMS1CLPTM1L0.744639303
PMS1GAA0.743623303
PMS1RNF2170.742946303
PMS1SFXN40.739255303
PMS1LARP70.737108303
PMS1SLC7A60.734785303
PMS1HPS50.722753303
PMS1GAL0.719244303
PMS1PDHX0.717441303
PMS1CHIC10.716857303
PMS1IQCE0.714315303
PMS1CELF10.710039505

For details and further investigation, click here