| Full name: protein tyrosine phosphatase non-receptor type 4 | Alias Symbol: PTPMEG | ||
| Type: protein-coding gene | Cytoband: 2q14.2 | ||
| Entrez ID: 5775 | HGNC ID: HGNC:9656 | Ensembl Gene: ENSG00000088179 | OMIM ID: 176878 |
| Drug and gene relationship at DGIdb | |||
Expression of PTPN4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTPN4 | 5775 | 205171_at | 0.5815 | 0.2371 | |
| GSE20347 | PTPN4 | 5775 | 205171_at | 0.2366 | 0.1383 | |
| GSE23400 | PTPN4 | 5775 | 205171_at | 0.3379 | 0.0000 | |
| GSE26886 | PTPN4 | 5775 | 205171_at | 0.7578 | 0.0000 | |
| GSE29001 | PTPN4 | 5775 | 205171_at | 0.3283 | 0.2677 | |
| GSE38129 | PTPN4 | 5775 | 205171_at | 0.4073 | 0.0075 | |
| GSE45670 | PTPN4 | 5775 | 205171_at | 0.3986 | 0.0177 | |
| GSE53622 | PTPN4 | 5775 | 126593 | -0.0958 | 0.2473 | |
| GSE53624 | PTPN4 | 5775 | 126593 | 0.2411 | 0.0002 | |
| GSE63941 | PTPN4 | 5775 | 205171_at | 0.4020 | 0.4992 | |
| GSE77861 | PTPN4 | 5775 | 205171_at | 0.5656 | 0.0106 | |
| GSE97050 | PTPN4 | 5775 | A_33_P3265920 | 0.1094 | 0.7629 | |
| SRP007169 | PTPN4 | 5775 | RNAseq | 0.2650 | 0.5722 | |
| SRP008496 | PTPN4 | 5775 | RNAseq | 0.3863 | 0.1988 | |
| SRP064894 | PTPN4 | 5775 | RNAseq | -0.1847 | 0.4208 | |
| SRP133303 | PTPN4 | 5775 | RNAseq | 0.0874 | 0.5933 | |
| SRP159526 | PTPN4 | 5775 | RNAseq | 0.1340 | 0.5200 | |
| SRP193095 | PTPN4 | 5775 | RNAseq | -0.0916 | 0.4786 | |
| SRP219564 | PTPN4 | 5775 | RNAseq | -0.2451 | 0.5265 | |
| TCGA | PTPN4 | 5775 | RNAseq | -0.1299 | 0.0463 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PTPN4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTPN4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTPN4 | 5775 | 6 | 2 | 22 | |
| GSE20123 | PTPN4 | 5775 | 6 | 2 | 22 | |
| GSE43470 | PTPN4 | 5775 | 3 | 1 | 39 | |
| GSE46452 | PTPN4 | 5775 | 2 | 3 | 54 | |
| GSE47630 | PTPN4 | 5775 | 6 | 0 | 34 | |
| GSE54993 | PTPN4 | 5775 | 0 | 6 | 64 | |
| GSE54994 | PTPN4 | 5775 | 12 | 0 | 41 | |
| GSE60625 | PTPN4 | 5775 | 0 | 3 | 8 | |
| GSE74703 | PTPN4 | 5775 | 3 | 1 | 32 | |
| GSE74704 | PTPN4 | 5775 | 3 | 1 | 16 | |
| TCGA | PTPN4 | 5775 | 32 | 6 | 58 |
Total number of gains: 73; Total number of losses: 25; Total Number of normals: 390.
Somatic mutations of PTPN4:
Generating mutation plots.
Highly correlated genes for PTPN4:
Showing top 20/1174 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTPN4 | DDX59 | 0.864374 | 3 | 0 | 3 |
| PTPN4 | PLEKHA3 | 0.858411 | 3 | 0 | 3 |
| PTPN4 | ZBTB37 | 0.819337 | 3 | 0 | 3 |
| PTPN4 | ZNF251 | 0.811453 | 3 | 0 | 3 |
| PTPN4 | SLC35E1 | 0.802121 | 3 | 0 | 3 |
| PTPN4 | CENPV | 0.789143 | 3 | 0 | 3 |
| PTPN4 | ZCCHC3 | 0.785865 | 3 | 0 | 3 |
| PTPN4 | THAP5 | 0.78221 | 3 | 0 | 3 |
| PTPN4 | GNS | 0.777355 | 3 | 0 | 3 |
| PTPN4 | DHX36 | 0.777193 | 5 | 0 | 4 |
| PTPN4 | DUSP23 | 0.773672 | 3 | 0 | 3 |
| PTPN4 | ZNF680 | 0.773432 | 3 | 0 | 3 |
| PTPN4 | FAM161B | 0.771595 | 3 | 0 | 3 |
| PTPN4 | TOP1MT | 0.766108 | 4 | 0 | 4 |
| PTPN4 | IMMP1L | 0.7658 | 3 | 0 | 3 |
| PTPN4 | GTF2H3 | 0.765335 | 3 | 0 | 3 |
| PTPN4 | CCDC150 | 0.763923 | 3 | 0 | 3 |
| PTPN4 | EIF2AK4 | 0.761508 | 3 | 0 | 3 |
| PTPN4 | POLR1B | 0.761098 | 5 | 0 | 4 |
| PTPN4 | SLC37A3 | 0.759991 | 3 | 0 | 3 |
For details and further investigation, click here
