| Full name: membrane associated guanylate kinase, WW and PDZ domain containing 2 | Alias Symbol: AIP1|ARIP1|KIAA0705|ACVRIP1|MAGI-2 | ||
| Type: protein-coding gene | Cytoband: 7q21.11 | ||
| Entrez ID: 9863 | HGNC ID: HGNC:18957 | Ensembl Gene: ENSG00000187391 | OMIM ID: 606382 |
| Drug and gene relationship at DGIdb | |||
MAGI2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway | |
| hsa04530 | Tight junction |
Expression of MAGI2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAGI2 | 9863 | 209737_at | -0.7759 | 0.3911 | |
| GSE20347 | MAGI2 | 9863 | 209737_at | -0.1228 | 0.6925 | |
| GSE23400 | MAGI2 | 9863 | 209737_at | -0.0667 | 0.4515 | |
| GSE26886 | MAGI2 | 9863 | 209737_at | 2.0950 | 0.0000 | |
| GSE29001 | MAGI2 | 9863 | 209737_at | 0.1725 | 0.7652 | |
| GSE38129 | MAGI2 | 9863 | 209737_at | -0.3339 | 0.2317 | |
| GSE45670 | MAGI2 | 9863 | 209737_at | -1.5382 | 0.0001 | |
| GSE53622 | MAGI2 | 9863 | 103244 | -0.7406 | 0.0000 | |
| GSE53624 | MAGI2 | 9863 | 103244 | -0.5555 | 0.0006 | |
| GSE63941 | MAGI2 | 9863 | 209737_at | -2.7517 | 0.0032 | |
| GSE77861 | MAGI2 | 9863 | 209737_at | 0.0918 | 0.6145 | |
| SRP007169 | MAGI2 | 9863 | RNAseq | 0.7537 | 0.2636 | |
| SRP008496 | MAGI2 | 9863 | RNAseq | 1.3142 | 0.0092 | |
| SRP064894 | MAGI2 | 9863 | RNAseq | -0.1397 | 0.5046 | |
| SRP133303 | MAGI2 | 9863 | RNAseq | -0.4800 | 0.0741 | |
| SRP159526 | MAGI2 | 9863 | RNAseq | 0.4554 | 0.0802 | |
| SRP193095 | MAGI2 | 9863 | RNAseq | 0.3340 | 0.0837 | |
| SRP219564 | MAGI2 | 9863 | RNAseq | -0.5534 | 0.3802 | |
| TCGA | MAGI2 | 9863 | RNAseq | -0.4238 | 0.0027 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by MAGI2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAGI2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAGI2 | 9863 | 13 | 1 | 16 | |
| GSE20123 | MAGI2 | 9863 | 12 | 1 | 17 | |
| GSE43470 | MAGI2 | 9863 | 4 | 1 | 38 | |
| GSE46452 | MAGI2 | 9863 | 11 | 0 | 48 | |
| GSE47630 | MAGI2 | 9863 | 7 | 3 | 30 | |
| GSE54993 | MAGI2 | 9863 | 1 | 7 | 62 | |
| GSE54994 | MAGI2 | 9863 | 15 | 3 | 35 | |
| GSE60625 | MAGI2 | 9863 | 0 | 0 | 11 | |
| GSE74703 | MAGI2 | 9863 | 3 | 1 | 32 | |
| GSE74704 | MAGI2 | 9863 | 8 | 1 | 11 | |
| TCGA | MAGI2 | 9863 | 44 | 9 | 43 |
Total number of gains: 118; Total number of losses: 27; Total Number of normals: 343.
Somatic mutations of MAGI2:
Generating mutation plots.
Highly correlated genes for MAGI2:
Showing top 20/718 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAGI2 | MICU3 | 0.788407 | 6 | 0 | 6 |
| MAGI2 | DACT3 | 0.752971 | 4 | 0 | 4 |
| MAGI2 | ZBTB26 | 0.739907 | 3 | 0 | 3 |
| MAGI2 | INMT | 0.735198 | 4 | 0 | 4 |
| MAGI2 | MYOCD | 0.732451 | 4 | 0 | 4 |
| MAGI2 | ZBTB47 | 0.720592 | 3 | 0 | 3 |
| MAGI2 | RNF150 | 0.719722 | 6 | 0 | 6 |
| MAGI2 | FIBIN | 0.712918 | 3 | 0 | 3 |
| MAGI2 | CNTN4 | 0.712467 | 3 | 0 | 3 |
| MAGI2 | CACNA1C | 0.704678 | 4 | 0 | 3 |
| MAGI2 | PWAR5 | 0.704592 | 3 | 0 | 3 |
| MAGI2 | PKDCC | 0.699528 | 5 | 0 | 5 |
| MAGI2 | PABPC5 | 0.689946 | 5 | 0 | 5 |
| MAGI2 | KCNT2 | 0.688562 | 6 | 0 | 6 |
| MAGI2 | FAM228B | 0.684679 | 5 | 0 | 5 |
| MAGI2 | BEND5 | 0.682458 | 7 | 0 | 6 |
| MAGI2 | CNN1 | 0.679794 | 5 | 0 | 5 |
| MAGI2 | RBM24 | 0.676142 | 6 | 0 | 5 |
| MAGI2 | DPYSL3 | 0.675346 | 7 | 0 | 7 |
| MAGI2 | NEGR1 | 0.67259 | 5 | 0 | 4 |
For details and further investigation, click here
