CACNA1C

 

Full name: calcium voltage-gated channel subunit alpha1 C Alias Symbol: Cav1.2|CACH2|CACN2|TS|LQT8
Type: protein-coding gene Cytoband: 12p13.33
Entrez ID: 775 HGNC ID: HGNC:1390 Ensembl Gene: ENSG00000151067 OMIM ID: 114205
Drug and gene relationship at DGIdb

 

CACNA1C involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04742Taste transduction
hsa04911Insulin secretion
hsa04921Oxytocin signaling pathway
hsa04930Type II diabetes mellitus
hsa05031Amphetamine addiction

 

Expression of CACNA1C:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CACNA1C 775 242973_at -0.6662 0.2256
GSE20347 CACNA1C 775 208020_s_at -0.0977 0.1558
GSE23400 CACNA1C 775 208020_s_at -0.1305 0.0018
GSE26886 CACNA1C 775 242973_at 0.1224 0.3380
GSE29001 CACNA1C 775 211592_s_at 0.1063 0.5629
GSE38129 CACNA1C 775 208020_s_at -0.2039 0.0028
GSE45670 CACNA1C 775 242973_at -0.7756 0.0000
GSE53622 CACNA1C 775 24568 -0.5585 0.0032
GSE53624 CACNA1C 775 21300 -0.1202 0.0836
GSE63941 CACNA1C 775 242973_at -1.1839 0.0000
GSE77861 CACNA1C 775 242973_at -0.1146 0.2176
GSE97050 CACNA1C 775 A_33_P3249394 -0.6939 0.1726
SRP007169 CACNA1C 775 RNAseq 3.0551 0.0001
SRP064894 CACNA1C 775 RNAseq 0.1046 0.7871
SRP133303 CACNA1C 775 RNAseq -0.1603 0.7333
SRP159526 CACNA1C 775 RNAseq -0.2275 0.6352
SRP193095 CACNA1C 775 RNAseq 1.3210 0.0000
SRP219564 CACNA1C 775 RNAseq -0.4761 0.6094
TCGA CACNA1C 775 RNAseq -0.6261 0.0001

Upregulated datasets: 2; Downregulated datasets: 1.  

 

Survival by CACNA1C expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CACNA1C:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CACNA1C 775 6 4 20
GSE20123 CACNA1C 775 6 4 20
GSE43470 CACNA1C 775 11 4 28
GSE46452 CACNA1C 775 10 1 48
GSE47630 CACNA1C 775 12 2 26
GSE54993 CACNA1C 775 1 10 59
GSE54994 CACNA1C 775 10 2 41
GSE60625 CACNA1C 775 0 1 10
GSE74703 CACNA1C 775 11 2 23
GSE74704 CACNA1C 775 4 2 14
TCGA CACNA1C 775 40 6 50

Total number of gains: 111; Total number of losses: 38; Total Number of normals: 339.  

 

Somatic mutations of CACNA1C:

 

Generating mutation plots.

 

Highly correlated genes for CACNA1C:

 

Showing top 20/812 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CACNA1CFILIP10.847408404
CACNA1CGMPR0.802152303
CACNA1CMGARP0.799098303
CACNA1CCNTN30.799056303
CACNA1CSMIM100.797837404
CACNA1CMAGI2-AS30.793007505
CACNA1CA2M-AS10.790534303
CACNA1CKCNT20.783369505
CACNA1CANGPTL10.782721505
CACNA1CINMT0.78271606
CACNA1CASB50.779412505
CACNA1CMRGPRF0.779144606
CACNA1CSHISA30.778962404
CACNA1CNEGR10.77845606
CACNA1CLRRN4CL0.776251606
CACNA1CMRVI10.772145605
CACNA1CRASD20.765981303
CACNA1CNHSL20.764442303
CACNA1CTOR1AIP10.763487505
CACNA1CLRCH10.762009505

For details and further investigation, click here