| Full name: protein kinase domain containing, cytoplasmic | Alias Symbol: SgK493|Vlk | ||
| Type: protein-coding gene | Cytoband: 2p21 | ||
| Entrez ID: 91461 | HGNC ID: HGNC:25123 | Ensembl Gene: ENSG00000162878 | OMIM ID: 614150 |
| Drug and gene relationship at DGIdb | |||
Expression of PKDCC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PKDCC | 91461 | 225380_at | -0.1776 | 0.9108 | |
| GSE26886 | PKDCC | 91461 | 225380_at | 0.5478 | 0.0414 | |
| GSE45670 | PKDCC | 91461 | 225380_at | -0.7446 | 0.0077 | |
| GSE53622 | PKDCC | 91461 | 111609 | -0.1876 | 0.3765 | |
| GSE53624 | PKDCC | 91461 | 111609 | 0.2382 | 0.0563 | |
| GSE63941 | PKDCC | 91461 | 225380_at | -2.0661 | 0.0009 | |
| GSE77861 | PKDCC | 91461 | 225380_at | 0.4238 | 0.2210 | |
| GSE97050 | PKDCC | 91461 | A_32_P112493 | -0.4412 | 0.1894 | |
| SRP064894 | PKDCC | 91461 | RNAseq | 0.7186 | 0.1495 | |
| SRP133303 | PKDCC | 91461 | RNAseq | -0.2928 | 0.5971 | |
| SRP159526 | PKDCC | 91461 | RNAseq | -0.0809 | 0.8532 | |
| SRP193095 | PKDCC | 91461 | RNAseq | 1.0488 | 0.1208 | |
| SRP219564 | PKDCC | 91461 | RNAseq | -0.2655 | 0.8108 | |
| TCGA | PKDCC | 91461 | RNAseq | -0.5914 | 0.0221 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PKDCC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PKDCC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PKDCC | 91461 | 12 | 1 | 17 | |
| GSE20123 | PKDCC | 91461 | 11 | 1 | 18 | |
| GSE43470 | PKDCC | 91461 | 3 | 0 | 40 | |
| GSE46452 | PKDCC | 91461 | 1 | 4 | 54 | |
| GSE47630 | PKDCC | 91461 | 7 | 0 | 33 | |
| GSE54993 | PKDCC | 91461 | 0 | 5 | 65 | |
| GSE54994 | PKDCC | 91461 | 10 | 0 | 43 | |
| GSE60625 | PKDCC | 91461 | 0 | 3 | 8 | |
| GSE74703 | PKDCC | 91461 | 3 | 0 | 33 | |
| GSE74704 | PKDCC | 91461 | 10 | 1 | 9 | |
| TCGA | PKDCC | 91461 | 35 | 2 | 59 |
Total number of gains: 92; Total number of losses: 17; Total Number of normals: 379.
Somatic mutations of PKDCC:
Generating mutation plots.
Highly correlated genes for PKDCC:
Showing top 20/229 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PKDCC | NAV3 | 0.80671 | 3 | 0 | 3 |
| PKDCC | FSIP1 | 0.733703 | 3 | 0 | 3 |
| PKDCC | SHC3 | 0.733116 | 3 | 0 | 3 |
| PKDCC | TFE3 | 0.714013 | 5 | 0 | 5 |
| PKDCC | TCEAL7 | 0.708913 | 5 | 0 | 5 |
| PKDCC | KRTAP19-1 | 0.707539 | 3 | 0 | 3 |
| PKDCC | MAGI2 | 0.699528 | 5 | 0 | 5 |
| PKDCC | SLC25A4 | 0.697875 | 4 | 0 | 4 |
| PKDCC | NPR2 | 0.696438 | 5 | 0 | 4 |
| PKDCC | ZNF781 | 0.688754 | 4 | 0 | 4 |
| PKDCC | RAD51D | 0.686761 | 4 | 0 | 4 |
| PKDCC | VIPR2 | 0.68335 | 4 | 0 | 4 |
| PKDCC | FAM71F1 | 0.679532 | 3 | 0 | 3 |
| PKDCC | BEND7 | 0.676548 | 5 | 0 | 5 |
| PKDCC | CTIF | 0.676027 | 4 | 0 | 4 |
| PKDCC | NRXN1 | 0.672689 | 5 | 0 | 4 |
| PKDCC | SYPL2 | 0.671215 | 5 | 0 | 4 |
| PKDCC | HEBP1 | 0.666747 | 5 | 0 | 4 |
| PKDCC | RASD2 | 0.666459 | 4 | 0 | 3 |
| PKDCC | SMAD9 | 0.66515 | 5 | 0 | 5 |
For details and further investigation, click here
